SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 5 THR A 301
THR A 292
HIS A 261
LEU A 345
 None
 1.18A 1d4fC-4fahA:
undetectable		 1d4fC-4fahA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 LYS A  15
TYR A  27
PRO A  17
 None
 1.04A 2j9cC-4fahA:
undetectable		 2j9cC-4fahA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 CYH A 281
PHE A 348
PHE A 346
 None
 0.83A 3cr5X-4fahA:
undetectable		 3cr5X-4fahA:
11.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		5 / 12 GLN A 108
HIS A 119
ARG A 127
HIS A 160
ASP A 174
 None
FE  A 401 (-3.2A)
None
FE  A 401 (-3.3A)
None
 1.34A 3njzA-4fahA:
49.2		 3njzA-4fahA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		5 / 12 GLN A 108
HIS A 119
ARG A 127
HIS A 162
ASP A 174
 None
FE  A 401 (-3.2A)
None
None
None
 1.34A 3njzA-4fahA:
49.2		 3njzA-4fahA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		5 / 12 GLN A 108
HIS A 119
ARG A 127
HIS A 162
ASP A 174
 None
FE  A 401 (-3.2A)
None
None
None
 1.49A 3njzA-4fahA:
49.2		 3njzA-4fahA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		5 / 12 HIS A 160
HIS A 121
ASP A 174
LEU A 176
ILE A 178
 FE  A 401 (-3.3A)
FE  A 401 (-3.4A)
None
None
None
 1.43A 3njzA-4fahA:
49.2		 3njzA-4fahA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		8 / 12 TRP A 104
GLN A 108
HIS A 119
HIS A 121
HIS A 160
ASP A 174
LEU A 176
ILE A 178
 None
None
FE  A 401 (-3.2A)
FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
None
None
None
 0.72A 3njzA-4fahA:
49.2		 3njzA-4fahA:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		6 / 6 GLN A 108
HIS A 119
HIS A 121
ARG A 127
HIS A 160
ASP A 174
 None
FE  A 401 (-3.2A)
FE  A 401 (-3.4A)
None
FE  A 401 (-3.3A)
None
 0.63A 3nvcA-4fahA:
53.1		 3nvcA-4fahA:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 6 HIS A 160
HIS A 119
HIS A 121
ASP A 174
 FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
FE  A 401 (-3.4A)
None
 1.16A 3nvcA-4fahA:
53.1		 3nvcA-4fahA:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.79A 3s33A-4fahA:
undetectable		 3s33A-4fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.78A 3s39A-4fahA:
undetectable		 3s39A-4fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.81A 3s3aA-4fahA:
undetectable		 3s3aA-4fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.77A 3s3cA-4fahA:
undetectable		 3s3cA-4fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.76A 3s3dA-4fahA:
undetectable		 3s3dA-4fahA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 ARG A 148
TRP A  61
GLY A 324
 None
 1.01A 4e7cA-4fahA:
undetectable		 4e7cA-4fahA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 5 ALA A 227
ILE A 230
LEU A 153
ASN A 268
 None
 1.10A 4g19A-4fahA:
undetectable		 4g19A-4fahA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 4 SER A  52
ASP A 350
MET A 354
ASP A 177
 None
 1.46A 4iv0A-4fahA:
undetectable		 4iv0A-4fahA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 LEU A  65
LEU A  64
TRP A  59
 None
 0.93A 5nwuA-4fahA:
undetectable		 5nwuA-4fahA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 5 THR A 301
THR A 292
HIS A 261
LEU A 345
 None
 1.23A 6aphA-4fahA:
undetectable		 6aphA-4fahA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		4 / 5 THR A 301
THR A 292
HIS A 261
LEU A 345
 None
 1.20A 6gbnB-4fahA:
undetectable		 6gbnB-4fahA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fah GENTISATE
1,2-DIOXYGENASE
(Pseudaminobacter
salicylatoxidans) 		3 / 3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.70A 6giqa-4fahA:
undetectable		 6giqa-4fahA:
20.11