SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 ALA A 165
LEU A 161
LEU A 124
ALA A 122
LEU A 182
 None
 1.17A 1ie4A-4faiA:
undetectable
1ie4C-4faiA:
undetectable		 1ie4A-4faiA:
15.45
1ie4C-4faiA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 LEU A 124
ALA A 122
LEU A 182
ALA A 165
LEU A 161
 None
 1.19A 1ie4A-4faiA:
undetectable
1ie4C-4faiA:
undetectable		 1ie4A-4faiA:
15.45
1ie4C-4faiA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 6 HIS A 318
ASP A 322
ASP A 321
PRO A 314
 ZN  A 401 ( 3.2A)
None
None
None
 1.49A 1ilqA-4faiA:
undetectable
1ilqC-4faiA:
undetectable		 1ilqA-4faiA:
11.62
1ilqC-4faiA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 11 ALA A 165
LEU A 161
LEU A 124
ALA A 122
LEU A 182
 None
 1.18A 1tz8A-4faiA:
undetectable
1tz8B-4faiA:
undetectable		 1tz8A-4faiA:
18.60
1tz8B-4faiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 11 LEU A 124
ALA A 122
LEU A 182
ALA A 165
LEU A 161
 None
 1.20A 1tz8A-4faiA:
undetectable
1tz8B-4faiA:
undetectable		 1tz8A-4faiA:
18.60
1tz8B-4faiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 LYS A 211
HIS A 116
SER A 104
VAL A 102
 None
 1.17A 1u1jA-4faiA:
undetectable		 1u1jA-4faiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 5 LEU A  72
PRO A 157
ALA A 155
ILE A  68
 None
 0.86A 2aofB-4faiA:
undetectable		 2aofB-4faiA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 11 ALA A 155
ILE A  73
ILE A  68
ALA A  67
VAL A  85
 None
 1.01A 2qhfA-4faiA:
undetectable		 2qhfA-4faiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 ILE A 202
ALA A 209
ILE A 121
ILE A 120
LEU A 224
 None
 1.10A 2rlcA-4faiA:
undetectable		 2rlcA-4faiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 7 TYR A 329
ALA A 155
LEU A 149
ALA A 324
 None
 1.12A 2vcvA-4faiA:
undetectable		 2vcvA-4faiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 TYR A 280
ILE A 338
TYR A 248
LEU A 308
LEU A 230
 None
 1.46A 2w98A-4faiA:
undetectable		 2w98A-4faiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 ILE A 251
TYR A 280
LEU A 230
LEU A 227
 None
 0.89A 2w98B-4faiA:
undetectable		 2w98B-4faiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 SER A 154
PHE A 281
LEU A 185
ASP A 294
GLU A 190
 None
None
None
None
PBD  A 402 (-3.5A)
 1.39A 3aocC-4faiA:
undetectable		 3aocC-4faiA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 MET A 223
GLU A 245
VAL A 254
ILE A 251
GLU A 255
 None
 1.34A 3jayA-4faiA:
undetectable		 3jayA-4faiA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 ASP A 153
LEU A 229
ASP A 293
ASP A 294
 ZN  A 401 ( 2.1A)
PBD  A 402 (-4.8A)
PBD  A 402 ( 4.1A)
None
 1.21A 3n2oC-4faiA:
undetectable
3n2oD-4faiA:
undetectable		 3n2oC-4faiA:
19.66
3n2oD-4faiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 6 HIS A 318
PRO A 314
LEU A 229
ASP A 293
 ZN  A 401 ( 3.2A)
None
PBD  A 402 (-4.8A)
PBD  A 402 ( 4.1A)
 1.13A 3oi8A-4faiA:
undetectable		 3oi8A-4faiA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 5 HIS A 307
ILE A 305
HIS A 295
LEU A 226
 None
 1.44A 3qpkA-4faiA:
undetectable		 3qpkA-4faiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 PHE A 240
LEU A 306
PHE A 241
ASN A 243
TYR A 346
 None
 1.48A 4eb4D-4faiA:
undetectable		 4eb4D-4faiA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 11 HIS A 137
ASP A 153
GLU A 190
GLU A 191
HIS A 318
 None
ZN  A 401 ( 2.1A)
PBD  A 402 (-3.5A)
ZN  A 401 ( 2.2A)
ZN  A 401 ( 3.2A)
 0.32A 4pqaA-4faiA:
22.1		 4pqaA-4faiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 5 LEU A 229
LEU A 226
PHE A 313
HIS A 137
 PBD  A 402 (-4.8A)
None
PBD  A 402 (-3.8A)
None
 0.95A 5gtrA-4faiA:
undetectable		 5gtrA-4faiA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 10 GLY A 231
ALA A 159
VAL A 156
ASP A 328
ILE A 327
 None
 0.99A 5i3cB-4faiA:
5.3		 5i3cB-4faiA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		3 / 3 LEU A 230
LEU A 229
TRP A 317
 None
PBD  A 402 (-4.8A)
PBD  A 402 (-4.7A)
 0.93A 5nwuA-4faiA:
undetectable		 5nwuA-4faiA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 VAL A  85
ILE A  89
ILE A 120
ASP A 188
THR A  79
 None
None
None
None
CL  A 403 ( 4.3A)
 0.86A 5uvmB-4faiA:
undetectable		 5uvmB-4faiA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 PHE A 241
PHE A 281
ILE A 339
PHE A 342
ALA A 343
 None
 0.91A 5veuB-4faiA:
undetectable		 5veuB-4faiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 VAL A  77
GLY A 204
ALA A 205
LEU A 224
LEU A 226
 None
 0.97A 5x23A-4faiA:
undetectable		 5x23A-4faiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		4 / 8 PRO A 235
THR A 332
THR A 331
TYR A 280
 None
 1.34A 5x2sI-4faiA:
undetectable
5x2sJ-4faiA:
undetectable
5x2sK-4faiA:
undetectable		 5x2sI-4faiA:
18.63
5x2sJ-4faiA:
17.65
5x2sK-4faiA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLU A 190
HIS A 137
ASP A 294
ASP A 153
ASP A 293
 PBD  A 402 (-3.5A)
None
None
ZN  A 401 ( 2.1A)
PBD  A 402 ( 4.1A)
 1.49A 5ximC-4faiA:
undetectable		 5ximC-4faiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 GLU A 190
HIS A 137
ASP A 294
ASP A 153
ASP A 293
 PBD  A 402 (-3.5A)
None
None
ZN  A 401 ( 2.1A)
PBD  A 402 ( 4.1A)
 1.50A 5ximD-4faiA:
undetectable		 5ximD-4faiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4fai CG5976, ISOFORM B
(Drosophila
melanogaster) 		5 / 12 VAL A  77
GLY A 204
ALA A 205
LEU A 224
LEU A 226
 None
 0.96A 5xxiA-4faiA:
undetectable		 5xxiA-4faiA:
22.20