SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		5 / 12 GLU A 417
LEU A 443
GLY A 422
TYR A 387
ALA A 446
 EDO  A 619 ( 4.8A)
None
None
None
None
 1.32A 1hvyB-4fasA:
undetectable		 1hvyB-4fasA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
NE1300
(Nitrosomonas
europaea) 		4 / 7 MET A 376
ASP A 377
ASP A 374
LYS D  23
 HEC  A 606 (-3.9A)
None
EDO  A 618 ( 4.1A)
None
 1.30A 1t03A-4fasA:
undetectable		 1t03A-4fasA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 6 THR A 214
PHE A 424
HIS A 233
ASN A 211
 PEG  A 614 (-4.0A)
PEG  A 614 ( 3.6A)
HEC  A 605 ( 3.4A)
None
 1.29A 1tt0A-4fasA:
undetectable		 1tt0A-4fasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 7 CYH A 172
CYH A 239
HIS A 243
HIS A  99
 HEC  A 603 ( 1.8A)
HEC  A 604 ( 1.8A)
HEC  A 604 (-3.3A)
HEC  A 603 ( 3.2A)
 1.46A 1yvmA-4fasA:
undetectable		 1yvmA-4fasA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		3 / 3 ARG A 223
ASN A 412
THR A 425
 None
 0.83A 2q63A-4fasA:
undetectable		 2q63A-4fasA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 8 GLU A 293
LEU A 114
ALA A 251
ALA A 250
 None
None
None
HEC  A 603 (-3.4A)
 0.93A 3ax9B-4fasA:
undetectable		 3ax9B-4fasA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 7 LEU A  13
ASP A 188
ARG A 187
ALA A  12
 None
None
PEG  A 610 ( 4.8A)
None
 1.14A 3mbgA-4fasA:
undetectable
3mbgB-4fasA:
undetectable		 3mbgA-4fasA:
12.82
3mbgB-4fasA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 6 TYR A  33
GLN A 236
ARG A 183
ASP A  59
 None
None
HEC  A 604 ( 4.3A)
None
 1.34A 4ax8A-4fasA:
undetectable		 4ax8A-4fasA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 6 TYR A  33
GLN A 236
ARG A 183
ASP A  59
 None
None
HEC  A 604 ( 4.3A)
None
 1.33A 4azvA-4fasA:
undetectable		 4azvA-4fasA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 5 ARG A 327
THR A   4
GLU A 320
THR A 322
 None
 1.44A 4eahA-4fasA:
3.0
4eahE-4fasA:
3.0
4eahG-4fasA:
undetectable		 4eahA-4fasA:
20.18
4eahE-4fasA:
20.18
4eahG-4fasA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		3 / 3 ARG A 165
TYR A 208
ASN A 241
 None
None
HEC  A 605 (-3.5A)
 0.90A 4ffwB-4fasA:
undetectable		 4ffwB-4fasA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		5 / 12 MET A 220
ALA A 226
PHE A 424
THR A 425
ASN A 448
 None
None
PEG  A 614 ( 3.6A)
None
None
 1.38A 4z7fA-4fasA:
0.0		 4z7fA-4fasA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		3 / 3 TRP A 217
ILE A  52
SER A  55
 None
 0.94A 5gqbA-4fasA:
undetectable		 5gqbA-4fasA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		3 / 3 TRP A 271
MET A 276
ASN A 461
 None
 1.45A 5uc1B-4fasA:
undetectable		 5uc1B-4fasA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		3 / 3 TRP A 271
MET A 276
ASN A 461
 None
 1.43A 5uc1A-4fasA:
undetectable		 5uc1A-4fasA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		4 / 4 GLU A 179
THR A 322
GLU A 186
HIS A  38
 HEC  A 604 (-3.7A)
None
None
None
 1.24A 5utuF-4fasA:
0.0		 5utuF-4fasA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4fas HYDROXYLAMINE
OXIDOREDUCTASE
(Nitrosomonas
europaea) 		5 / 12 PRO A 335
LEU A 450
LEU A 457
GLY A 456
ASN A 269
 None
 1.03A 6qxsB-4fasA:
undetectable		 6qxsB-4fasA:
21.17