SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		3 / 3 ASP A  53
THR A  84
GLU A 195
 None
GOL  A 304 ( 3.9A)
GOL  A 303 ( 2.9A)
 0.78A 1pj7A-4fayA:
3.2		 1pj7A-4fayA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		6 / 12 ILE A  94
ALA A  63
LEU A 112
THR A  71
ARG A 105
ILE A  96
 None
 1.37A 1ra8A-4fayA:
undetectable		 1ra8A-4fayA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		5 / 12 GLY A  88
GLY A  89
ILE A 164
MET A 168
LEU A 130
 None
GOL  A 303 (-3.6A)
None
None
None
 0.99A 1v2xA-4fayA:
undetectable		 1v2xA-4fayA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		5 / 11 GLY A  88
GLY A  89
ILE A 164
MET A 168
LEU A 130
 None
GOL  A 303 (-3.6A)
None
None
None
 1.00A 1x7pA-4fayA:
undetectable
1x7pB-4fayA:
undetectable		 1x7pA-4fayA:
23.42
1x7pB-4fayA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		4 / 4 GLY A 159
GLY A 165
GLY A 163
GLY A 196
 None
 0.66A 3bogD-4fayA:
undetectable		 3bogD-4fayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		5 / 10 LEU A 112
ARG A 117
PHE A 119
THR A  55
ASP A  22
 None
None
None
GOL  A 304 (-4.6A)
None
 0.82A 4driB-4fayA:
1.5		 4driB-4fayA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 LEU A 112
PHE A 119
THR A  55
ASP A  22
 None
None
GOL  A 304 (-4.6A)
None
 0.81A 4drjB-4fayA:
undetectable		 4drjB-4fayA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		5 / 9 ILE A 237
TYR A 236
GLY A 155
THR A 199
LEU A 146
 None
 1.47A 4wmzA-4fayA:
undetectable		 4wmzA-4fayA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		5 / 8 ILE A 237
TYR A 236
GLY A 155
THR A 199
LEU A 146
 None
 1.49A 5esfA-4fayA:
undetectable		 5esfA-4fayA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 GLU A  66
PHE A 119
GLY A 120
THR A  55
 None
None
None
GOL  A 304 (-4.6A)
 0.98A 5flcB-4fayA:
2.0		 5flcB-4fayA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		4 / 8 GLU A  66
PHE A 119
GLY A 120
THR A  55
 None
None
None
GOL  A 304 (-4.6A)
 0.98A 5flcF-4fayA:
undetectable		 5flcF-4fayA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		3 / 3 ALA A 111
ASN A 114
LEU A 115
 None
 0.20A 5i1oC-4fayA:
undetectable		 5i1oC-4fayA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4fay MICROCOMPARTMENTS
PROTEIN
(Lactobacillus
reuteri) 		3 / 3 ALA A 111
ASN A 114
LEU A 115
 None
 0.26A 5i1pA-4fayA:
undetectable		 5i1pA-4fayA:
13.14