SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		4 / 8 GLY A 116
TYR A 118
GLU A 175
ARG A 178
 AMP  A 301 ( 3.8A)
None
AMP  A 301 ( 4.8A)
AMP  A 301 (-3.0A)
 0.54A 1mrjA-4fbhA:
24.7		 1mrjA-4fbhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		4 / 8 ARG A  39
SER A  45
ARG A  48
VAL A  50
 None
 1.29A 1u1jA-4fbhA:
undetectable		 1u1jA-4fbhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 10 LEU A  77
SER A  93
ARG A 148
ALA A 165
ALA A 162
 None
 1.44A 1wygA-4fbhA:
undetectable		 1wygA-4fbhA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		4 / 6 ILE A  86
ARG A  82
LEU A  51
ASP A  84
 None
 1.01A 2rlfA-4fbhA:
undetectable
2rlfD-4fbhA:
undetectable		 2rlfA-4fbhA:
9.61
2rlfD-4fbhA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 11 SER A  45
PHE A 236
ALA A 247
ARG A 178
LEU A 216
 None
None
None
AMP  A 301 (-3.0A)
None
 1.26A 2v0mA-4fbhA:
undetectable		 2v0mA-4fbhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 11 SER A  45
PHE A 236
ALA A 247
ARG A 178
LEU A 216
 None
None
None
AMP  A 301 (-3.0A)
None
 1.29A 2v0mD-4fbhA:
undetectable		 2v0mD-4fbhA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 10 ALA A 141
ILE A 202
LEU A 133
ILE A  31
ILE A  86
 None
 1.24A 3prsA-4fbhA:
undetectable		 3prsA-4fbhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 AMP  A 301 ( 4.8A)
None
None
 0.58A 4v1fA-4fbhA:
undetectable		 4v1fA-4fbhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		3 / 3 GLU A 175
ALA A 176
PHE A 179
 AMP  A 301 ( 4.8A)
None
None
 0.54A 4v1fC-4fbhA:
undetectable		 4v1fC-4fbhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 12 LEU A 169
GLY A 134
PHE A  30
THR A  29
VAL A  66
 None
 1.17A 5d0yA-4fbhA:
undetectable		 5d0yA-4fbhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		4 / 4 PHE A  64
LEU A 105
LEU A  88
VAL A   9
 None
 1.09A 5xxiA-4fbhA:
undetectable		 5xxiA-4fbhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4fbh PROTEIN SYNTHESIS
INHIBITOR I
(Hordeum
vulgare) 		5 / 10 ALA A 165
LEU A  88
LEU A 101
LEU A  77
LEU A  79
 None
 0.92A 6f5uA-4fbhA:
undetectable
6f5uB-4fbhA:
undetectable		 6f5uA-4fbhA:
16.00
6f5uB-4fbhA:
13.72