SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 10 GLY A  57
PHE A  58
SER A 126
MET A 127
HIS A 257
 SPD  A 301 (-3.5A)
None
SPD  A 301 ( 2.3A)
None
SPD  A 301 (-3.2A)
 0.84A 1a8uA-4fblA:
21.7		 1a8uA-4fblA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 10 GLY A  57
PHE A  58
SER A 126
MET A 127
HIS A 257
 SPD  A 301 (-3.5A)
None
SPD  A 301 ( 2.3A)
None
SPD  A 301 (-3.2A)
 0.84A 1a8uB-4fblA:
21.6		 1a8uB-4fblA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 ALA A 130
GLY A 128
LEU A 212
GLU A 209
ALA A 208
 None
 1.14A 1mjqC-4fblA:
undetectable
1mjqD-4fblA:
undetectable		 1mjqC-4fblA:
17.90
1mjqD-4fblA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 HIS A 257
VAL A 258
THR A  59
LEU A 188
 SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.3A)
None
 1.03A 1oq5A-4fblA:
undetectable		 1oq5A-4fblA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.39A 1p6kB-4fblA:
undetectable		 1p6kB-4fblA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.40A 1rs6B-4fblA:
undetectable		 1rs6B-4fblA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.39A 1zzqB-4fblA:
undetectable		 1zzqB-4fblA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.36A 1zzuA-4fblA:
undetectable		 1zzuA-4fblA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.39A 1zzuB-4fblA:
undetectable		 1zzuB-4fblA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 LEU A 113
ILE A  50
SER A  48
GLY A  47
 None
 0.99A 2otfA-4fblA:
undetectable		 2otfA-4fblA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 7 ASP A 227
VAL A 230
ALA A 152
THR A 260
 None
None
CL  A 302 ( 4.8A)
None
 1.08A 2q6oA-4fblA:
2.8		 2q6oA-4fblA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 HIS A  87
GLY A  60
GLY A 128
ALA A  99
ASP A 101
 None
SPD  A 301 ( 3.8A)
None
None
None
 1.13A 3keeD-4fblA:
undetectable		 3keeD-4fblA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.89A 3sufB-4fblA:
undetectable		 3sufB-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 1.01A 3sufD-4fblA:
undetectable		 3sufD-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 ALA A 151
MET A 122
ALA A 135
ALA A 208
ILE A 106
 None
 1.00A 3ut5D-4fblA:
3.5		 3ut5D-4fblA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 8 ARG A 225
ASP A 264
LEU A 252
ASN A 150
ILE A 149
 None
 1.41A 4k0bA-4fblA:
undetectable		 4k0bA-4fblA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.41A 4kcnB-4fblA:
0.3		 4kcnB-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 11 VAL A 107
PHE A 143
GLY A 128
GLY A 129
ILE A 204
 None
 1.33A 4zvmA-4fblA:
4.8
4zvmB-4fblA:
4.1		 4zvmA-4fblA:
21.99
4zvmB-4fblA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 GLY A 128
ILE A 204
ILE A 149
ASN A 150
PHE A  58
 None
 1.13A 5fa8A-4fblA:
2.5		 5fa8A-4fblA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 6 ILE A 238
VAL A 215
VAL A 133
SER A 244
 None
 0.83A 5jwaH-4fblA:
2.0		 5jwaH-4fblA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 8 SER A 255
SER A 224
MET A  65
SER A 126
 None
None
None
SPD  A 301 ( 2.3A)
 1.02A 5l5fY-4fblA:
undetectable
5l5fZ-4fblA:
undetectable		 5l5fY-4fblA:
21.20
5l5fZ-4fblA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 12 ALA A 219
MET A 122
GLY A 128
LEU A 153
ILE A 221
 None
 0.98A 5m24A-4fblA:
undetectable		 5m24A-4fblA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 HIS A  56
GLY A  88
ARG A  83
THR A  89
 None
 1.45A 5nn4A-4fblA:
1.8		 5nn4A-4fblA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 5 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.40A 5vunA-4fblA:
undetectable		 5vunA-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.40A 5vunB-4fblA:
0.0		 5vunB-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.40A 5vuoA-4fblA:
0.3		 5vuoA-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		5 / 9 THR A  59
GLY A  60
ALA A 189
GLY A  57
SER A 126
 SPD  A 301 (-3.3A)
SPD  A 301 ( 3.8A)
SPD  A 301 (-3.2A)
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.72A 5vw4A-4fblA:
undetectable		 5vw4A-4fblA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 4 GLY A 137
GLN A 138
TRP A 134
VAL A 207
 None
 1.37A 6auuB-4fblA:
0.0		 6auuB-4fblA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 6 GLY A 129
LEU A 131
VAL A 229
PHE A  58
 None
 0.86A 6h7lA-4fblA:
undetectable		 6h7lA-4fblA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4fbl LIPS LIPOLYTIC
ENZYME
(unidentified) 		4 / 6 GLY A 129
LEU A 131
VAL A 229
PHE A  58
 None
 0.85A 6h7lB-4fblA:
undetectable		 6h7lB-4fblA:
15.13