SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ILE A1340
SER A1324
ILE A1325
PRO A1326
ASN A1331
None
1.09A 1dlsA-4fbqA:
undetectable
1dlsA-4fbqA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 7 ILE A1347
ARG A1399
PHE A1396
PHE A1392
None
1.25A 1e71M-4fbqA:
3.0
1e71M-4fbqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 7 ILE A1347
ARG A1399
PHE A1396
PHE A1392
None
1.25A 1e72M-4fbqA:
undetectable
1e72M-4fbqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 9 LEU A1376
GLU A1349
LYS A1315
ILE A1317
VAL A1335
None
1.23A 1gx8A-4fbqA:
undetectable
1gx8A-4fbqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 VAL A1127
LEU A1306
PHE A1045
THR A1274
GLY A1064
None
1.22A 1ia0B-4fbqA:
undetectable
1ia0B-4fbqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 7 HIS A1222
LEU A1062
SER A1024
ASP A1025
MN  A1501 (-3.6A)
None
None
MN  A1502 (-3.2A)
0.84A 1ismB-4fbqA:
undetectable
1ismB-4fbqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1065
HIS A1134
HIS A1027
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
0.57A 1oe1A-4fbqA:
undetectable
1oe1A-4fbqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1065
HIS A1134
HIS A1027
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
0.57A 1oe3A-4fbqA:
undetectable
1oe3A-4fbqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 VAL A1127
LEU A1306
PHE A1045
THR A1274
GLY A1064
None
1.22A 1tubB-4fbqA:
undetectable
1tubB-4fbqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 HIS A1228
ASP A1191
ASN A1133
None
None
MN  A1501 (-2.5A)
0.88A 1wg8B-4fbqA:
undetectable
1wg8B-4fbqA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1065
HIS A1134
HIS A1027
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
0.58A 2xxgA-4fbqA:
undetectable
2xxgA-4fbqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1065
HIS A1134
HIS A1027
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
0.59A 2xxgC-4fbqA:
undetectable
2xxgC-4fbqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.06A 2zweA-4fbqA:
undetectable
2zweB-4fbqA:
undetectable
2zweA-4fbqA:
21.36
2zweB-4fbqA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.12A 2zwfA-4fbqA:
undetectable
2zwfB-4fbqA:
undetectable
2zwfA-4fbqA:
21.36
2zwfB-4fbqA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 6 ILE A1114
TYR A1116
LEU A1292
MET A1059
None
1.16A 3adsA-4fbqA:
undetectable
3adsA-4fbqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 TYR A1260
ASN A1261
LYS A1265
PHE A1205
None
1.20A 3bjwD-4fbqA:
undetectable
3bjwD-4fbqA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASN A1133
ASP A1135
ARG A1037
MN  A1501 (-2.5A)
None
None
0.85A 3k13C-4fbqA:
undetectable
3k13C-4fbqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1101
ASN A1113
SER A1170
None
0.98A 3lslA-4fbqA:
undetectable
3lslD-4fbqA:
undetectable
3lslA-4fbqA:
19.42
3lslD-4fbqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 HIS A1068
HIS A1027
HIS A1134
None
MN  A1502 (-3.5A)
None
0.76A 3mihA-4fbqA:
undetectable
3mihA-4fbqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 VAL A1127
LEU A1062
VAL A1057
ALA A1052
LEU A1049
None
1.27A 3pghA-4fbqA:
undetectable
3pghA-4fbqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 5 VAL A1127
LEU A1084
LEU A1049
ILE A1066
None
0.83A 4a9jA-4fbqA:
undetectable
4a9jA-4fbqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 5 VAL A1127
LEU A1084
LEU A1049
ILE A1066
None
0.86A 4a9jB-4fbqA:
undetectable
4a9jB-4fbqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 5 VAL A1127
LEU A1084
LEU A1049
ILE A1066
None
0.92A 4a9jC-4fbqA:
undetectable
4a9jC-4fbqA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 HIS A1134
ASP A1065
PRO A1026
HIS A1027
GLY A1132
None
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
None
1.42A 4bz6A-4fbqA:
undetectable
4bz6A-4fbqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 HIS A1134
ASP A1065
PRO A1026
HIS A1027
GLY A1132
None
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
None
1.44A 4bz6A-4fbqA:
undetectable
4bz6B-4fbqA:
undetectable
4bz6A-4fbqA:
22.96
4bz6B-4fbqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 HIS A1134
ASP A1065
PRO A1026
HIS A1027
GLY A1132
None
MN  A1501 ( 3.0A)
None
MN  A1502 (-3.5A)
None
1.43A 4bz6D-4fbqA:
undetectable
4bz6D-4fbqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 ASN A1261
PHE A1266
VAL A1246
HIS A1225
None
1.14A 4f5zA-4fbqA:
undetectable
4f5zA-4fbqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ILE A1340
SER A1324
ILE A1325
PRO A1326
ASN A1331
None
1.08A 4gh8A-4fbqA:
undetectable
4gh8A-4fbqA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ILE A1340
SER A1324
ILE A1325
PRO A1326
ASN A1331
None
1.15A 4gh8B-4fbqA:
undetectable
4gh8B-4fbqA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 GLY A1063
GLY A1249
ILE A1066
HIS A1131
LEU A1146
None
1.10A 4mwzA-4fbqA:
undetectable
4mwzA-4fbqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 10 VAL A1155
LEU A1062
ALA A1080
SER A1083
LEU A1084
None
1.13A 4ph9A-4fbqA:
undetectable
4ph9A-4fbqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 5 ILE A1275
SER A1278
HIS A1252
ASP A1069
None
None
MN  A1502 (-3.7A)
None
1.15A 4rzvB-4fbqA:
undetectable
4rzvB-4fbqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 GLY A1132
ASP A1135
PHE A1158
ILE A1130
HIS A1250
None
None
None
None
MN  A1501 (-3.3A)
1.28A 4wh5A-4fbqA:
undetectable
4wh5A-4fbqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 ASP A1136
GLY A1132
ASP A1065
None
None
MN  A1501 ( 3.0A)
0.61A 4xdtA-4fbqA:
undetectable
4xdtA-4fbqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 ILE A1275
LEU A1279
ASP A1034
GLY A1031
ALA A1401
None
1.23A 5fctA-4fbqA:
undetectable
5fctA-4fbqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 6 ASP A1025
HIS A1027
HIS A1252
HIS A1222
MN  A1502 (-3.2A)
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.6A)
0.93A 5ncdA-4fbqA:
undetectable
5ncdD-4fbqA:
undetectable
5ncdA-4fbqA:
20.36
5ncdD-4fbqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 6 ASP A1065
ASP A1025
HIS A1027
HIS A1252
MN  A1501 ( 3.0A)
MN  A1502 (-3.2A)
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
0.93A 5nelA-4fbqA:
undetectable
5nelD-4fbqA:
undetectable
5nelA-4fbqA:
20.36
5nelD-4fbqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 6 ASP A1065
HIS A1027
HIS A1252
HIS A1222
MN  A1501 ( 3.0A)
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.6A)
0.93A 5nelB-4fbqA:
undetectable
5nelC-4fbqA:
undetectable
5nelB-4fbqA:
20.36
5nelC-4fbqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 VAL A1335
TYR A1384
GLN A1385
None
0.43A 5qgkA-4fbqA:
undetectable
5qgkA-4fbqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 VAL A1335
TYR A1384
GLN A1385
None
0.38A 5qgrA-4fbqA:
undetectable
5qgrA-4fbqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 VAL A1335
TYR A1384
GLN A1385
None
0.43A 5qgtA-4fbqA:
undetectable
5qgtA-4fbqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 ILE A1114
PHE A1128
PRO A1093
PRO A1126
None
1.06A 5x23A-4fbqA:
undetectable
5x23A-4fbqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
4 / 8 GLU A1283
PHE A1045
SER A1129
LEU A1084
None
0.93A 5y2tB-4fbqA:
undetectable
5y2tB-4fbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.09A 5z0fA-4fbqA:
undetectable
5z0fB-4fbqA:
undetectable
5z0fA-4fbqA:
10.02
5z0fB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.06A 5z0gA-4fbqA:
undetectable
5z0gB-4fbqA:
undetectable
5z0gA-4fbqA:
10.02
5z0gB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.14A 5z0hA-4fbqA:
undetectable
5z0hB-4fbqA:
undetectable
5z0hA-4fbqA:
10.02
5z0hB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.11A 5z0iA-4fbqA:
undetectable
5z0iB-4fbqA:
undetectable
5z0iA-4fbqA:
10.02
5z0iB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.08A 5z0jA-4fbqA:
undetectable
5z0jB-4fbqA:
undetectable
5z0jA-4fbqA:
10.02
5z0jB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 11 HIS A1027
HIS A1252
HIS A1250
HIS A1222
VAL A1221
MN  A1502 (-3.5A)
MN  A1502 (-3.7A)
MN  A1501 (-3.3A)
MN  A1501 (-3.6A)
None
1.08A 5z0kA-4fbqA:
undetectable
5z0kB-4fbqA:
undetectable
5z0kA-4fbqA:
10.02
5z0kB-4fbqA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A1076
LYS A1033
ALA A1080
PRO A1072
PHE A1067
None
1.28A 5zvgB-4fbqA:
undetectable
5zvgB-4fbqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomy
ces
pombe)
3 / 3 TYR A1243
ASP A1241
GLN A1240
None
0.77A 6g1pA-4fbqA:
undetectable
6g1pA-4fbqA:
21.59