SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		3 / 3 ARG A 174
ARG A 172
ARG A 160
 SO4  A 307 (-3.1A)
None
SO4  A 307 (-3.6A)
 1.04A 1l7fA-4fbzA:
undetectable		 1l7fA-4fbzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		3 / 3 ARG A 174
ARG A 172
ARG A 160
 SO4  A 307 (-3.1A)
None
SO4  A 307 (-3.6A)
 1.04A 1l7hA-4fbzA:
undetectable		 1l7hA-4fbzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 4 ASP A 114
LEU A  94
LEU A  91
LEU A  93
 None
None
L2P  A 304 ( 4.9A)
None
 1.28A 1u18A-4fbzA:
undetectable		 1u18A-4fbzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 8 THR A  16
TRP A  11
LEU A 213
MET A 209
 None
 1.47A 1uw6A-4fbzA:
undetectable
1uw6B-4fbzA:
undetectable		 1uw6A-4fbzA:
18.82
1uw6B-4fbzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 8 THR A  16
TRP A  11
LEU A 213
MET A 209
 None
 1.49A 1uw6D-4fbzA:
undetectable
1uw6E-4fbzA:
undetectable		 1uw6D-4fbzA:
18.82
1uw6E-4fbzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 8 TRP A  11
LEU A 213
MET A 209
THR A  16
 None
 1.46A 1uw6P-4fbzA:
undetectable
1uw6T-4fbzA:
undetectable		 1uw6P-4fbzA:
18.82
1uw6T-4fbzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 THR A  88
PHE A 170
LEU A 147
VAL A 150
LEU A 151
 RET  A 301 ( 4.6A)
None
None
None
None
 1.44A 2zb8A-4fbzA:
undetectable		 2zb8A-4fbzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 SER A 156
LEU A 110
ILE A 107
ILE A  48
GLY A 220
 SO4  A 307 (-3.4A)
None
BNG  A 305 ( 3.8A)
None
None
 1.26A 3cv9A-4fbzA:
undetectable		 3cv9A-4fbzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 12 GLY A  64
ALA A  58
ILE A  51
ILE A  48
MET A  19
 None
 1.38A 3ld6A-4fbzA:
undetectable		 3ld6A-4fbzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		3 / 3 THR A  76
VAL A  65
GLU A 193
 None
 0.58A 3v4tA-4fbzA:
undetectable
3v4tD-4fbzA:
undetectable		 3v4tA-4fbzA:
18.20
3v4tD-4fbzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 5 LEU A 148
LEU A 182
THR A 141
TRP A 137
 None
None
RET  A 301 (-3.9A)
RET  A 301 (-4.7A)
 1.35A 4do3A-4fbzA:
undetectable		 4do3A-4fbzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 12 GLY A  30
THR A  46
ILE A  48
THR A  88
GLY A 220
 22B  A 302 (-3.6A)
22B  A 302 (-3.9A)
None
RET  A 301 ( 4.6A)
None
 1.24A 4n48A-4fbzA:
undetectable		 4n48A-4fbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 12 LEU A 223
LEU A  92
ILE A 178
LEU A 151
LEU A 180
 None
 1.06A 5toaB-4fbzA:
undetectable		 5toaB-4fbzA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 12 LEU A 223
LEU A  92
LEU A  96
ILE A 178
LEU A 151
 None
 1.09A 5toaB-4fbzA:
undetectable		 5toaB-4fbzA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_A_HSMA401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.39A 6fu4A-4fbzA:
0.0		 6fu4A-4fbzA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_C_HSMC401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.42A 6fu4C-4fbzA:
0.0		 6fu4C-4fbzA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_D_HSMD401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.44A 6fu4D-4fbzA:
0.0		 6fu4D-4fbzA:
15.06