SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 PHE A 893
GLY A 717
PHE A 895
GLY A 861
VAL A 729
 None
 1.43A 2fqyA-4fc2A:
undetectable		 2fqyA-4fc2A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 ALA A 841
ILE A 817
VAL A 858
ALA A 859
ILE A 719
 None
 1.09A 2h42B-4fc2A:
undetectable		 2h42B-4fc2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 ALA A 841
ILE A 817
VAL A 858
ALA A 859
ILE A 719
 None
 1.06A 2h42C-4fc2A:
undetectable		 2h42C-4fc2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 ILE A 776
THR A 689
VAL A 736
LEU A 768
PHE A 764
 None
 1.26A 2jn3A-4fc2A:
undetectable		 2jn3A-4fc2A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 TYR A 782
LEU A 672
SER A 619
ALA A 624
GLU A 621
 None
 1.30A 2vdmA-4fc2A:
1.0
2vdmB-4fc2A:
undetectable		 2vdmA-4fc2A:
23.79
2vdmB-4fc2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		3 / 3 MET A 907
VAL A 953
GLU A 913
 None
 0.90A 3c6gA-4fc2A:
undetectable		 3c6gA-4fc2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 7 GLN A 828
GLY A 864
GLY A 870
ALA A 819
 None
 0.81A 3fpjB-4fc2A:
undetectable		 3fpjB-4fc2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 5 SER A 466
ARG A 468
PRO A 469
VAL A 475
 SO4  A1001 (-3.0A)
SO4  A1001 (-3.1A)
None
None
 0.87A 3sufC-4fc2A:
undetectable		 3sufC-4fc2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 5 ALA A 594
ILE A 532
LEU A 536
ASN A 629
 None
 0.92A 4g19A-4fc2A:
undetectable		 4g19A-4fc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		3 / 3 PHE A 673
THR A 634
LEU A 546
 None
 0.47A 4qztA-4fc2A:
0.7		 4qztA-4fc2A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 7 ASN A 653
PHE A 654
TRP A 561
PHE A 563
 None
 1.14A 4v32A-4fc2A:
undetectable		 4v32A-4fc2A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 7 ASN A 653
PHE A 654
TRP A 561
PHE A 563
 None
 1.13A 4v32B-4fc2A:
undetectable		 4v32B-4fc2A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 7 PHE A 910
LEU A 911
VAL A 953
PHE A 948
 None
 0.84A 4wnvD-4fc2A:
undetectable		 4wnvD-4fc2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 12 GLY A 723
HIS A 798
TYR A 785
GLN A 781
ILE A 754
 None
SO4  A1007 (-3.8A)
None
None
None
 1.35A 4ynmB-4fc2A:
undetectable		 4ynmB-4fc2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 8 TRP A 863
GLU A 837
HIS A 770
THR A 691
 None
 1.38A 5hqaA-4fc2A:
undetectable		 5hqaA-4fc2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		5 / 11 LEU A 711
ALA A 857
GLY A 723
ILE A 719
VAL A 713
 None
 1.12A 5kr2B-4fc2A:
undetectable		 5kr2B-4fc2A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 5 LEU A 627
VAL A 760
MET A 618
CYH A 601
 None
 1.48A 5te0A-4fc2A:
undetectable		 5te0A-4fc2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Mus
musculus) 		4 / 7 TYR A 950
LEU A 924
TYR A 946
VAL A 921
 None
 1.07A 6g2pA-4fc2A:
undetectable		 6g2pA-4fc2A:
22.64