SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 181
PHE A 208
ILE A 183
PHE A 263
ILE A 278
 None
 1.28A 1osvB-4fchA:
undetectable		 1osvB-4fchA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 192
GLY A 249
PHE A 253
SER A 248
 None
 1.31A 2a3cB-4fchA:
undetectable		 2a3cB-4fchA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 352
ARG A 326
ILE A 375
ARG A 350
GLU A 339
 None
GLC  A 405 ( 2.7A)
None
GLC  A 406 (-3.0A)
None
 1.13A 2j0dA-4fchA:
undetectable		 2j0dA-4fchA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 326
GLU A 339
TYR A 202
TRP A 336
 GLC  A 405 ( 2.7A)
None
EDO  A 413 ( 4.5A)
GLC  A 406 ( 3.7A)
 1.28A 2q6uA-4fchA:
0.0		 2q6uA-4fchA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 278
GLN A 207
ILE A 183
LEU A 333
 None
 1.18A 3dzyD-4fchA:
undetectable		 3dzyD-4fchA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 0.96A 3ko0B-4fchA:
undetectable
3ko0J-4fchA:
undetectable		 3ko0B-4fchA:
15.07
3ko0J-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 0.96A 3ko0D-4fchA:
undetectable
3ko0E-4fchA:
undetectable		 3ko0D-4fchA:
15.07
3ko0E-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.96A 3ko0B-4fchA:
undetectable
3ko0J-4fchA:
undetectable		 3ko0B-4fchA:
15.07
3ko0J-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 1.00A 3ko0K-4fchA:
undetectable
3ko0S-4fchA:
undetectable		 3ko0K-4fchA:
15.07
3ko0S-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 1.02A 3ko0L-4fchA:
undetectable
3ko0N-4fchA:
undetectable		 3ko0L-4fchA:
15.07
3ko0N-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.97A 3ko0K-4fchA:
undetectable
3ko0S-4fchA:
undetectable		 3ko0K-4fchA:
15.07
3ko0S-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.98A 3ko0R-4fchA:
undetectable
3ko0T-4fchA:
undetectable		 3ko0R-4fchA:
15.07
3ko0T-4fchA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 ALA A 381
GLY A 382
THR A 383
GLU A 346
 None
 0.66A 3rglA-4fchA:
undetectable		 3rglA-4fchA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.42A 3t3qA-4fchA:
undetectable		 3t3qA-4fchA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.43A 3t3qB-4fchA:
undetectable		 3t3qB-4fchA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.42A 3t3qC-4fchA:
undetectable		 3t3qC-4fchA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.40A 3t3qD-4fchA:
undetectable		 3t3qD-4fchA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 241
ALA A 245
GLY A 246
VAL A 239
VAL A 254
 None
 1.33A 4c5nD-4fchA:
undetectable		 4c5nD-4fchA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 281
LYS A 242
VAL A 201
GLY A 200
LEU A 333
 None
 1.34A 4or0A-4fchA:
undetectable		 4or0A-4fchA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 304
LEU A 287
MET A 327
MET A 319
 None
 1.00A 4rjdB-4fchA:
undetectable		 4rjdB-4fchA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 4fch OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 352
ARG A 350
ILE A 355
GLU A 360
 None
GLC  A 406 (-3.0A)
GLC  A 407 (-4.6A)
None
 1.43A 4zzcD-4fchA:
0.5
4zzcE-4fchA:
0.4		 4zzcD-4fchA:
19.57
4zzcE-4fchA:
19.57