SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 TRP A 164
ALA A 167
VAL A 163
 None
 0.95A 1av2C-4fcsA:
undetectable
1av2D-4fcsA:
undetectable		 1av2C-4fcsA:
6.25
1av2D-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 TRP A 164
ALA A 167
VAL A 163
 None
 0.83A 1bdwA-4fcsA:
undetectable
1bdwB-4fcsA:
undetectable		 1bdwA-4fcsA:
6.25
1bdwB-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 ALA A 266
PHE A 122
SER A  98
ILE A  97
LEU A  17
 None
 0.97A 1drfA-4fcsA:
undetectable		 1drfA-4fcsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 PHE A 186
LEU A 166
SER A 230
 HEM  A 401 (-4.9A)
HEM  A 401 (-4.9A)
HEM  A 401 (-3.5A)
 0.84A 1e7aA-4fcsA:
undetectable		 1e7aA-4fcsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 ALA A 167
VAL A 163
TRP A 164
 None
 0.80A 1w5uA-4fcsA:
undetectable
1w5uB-4fcsA:
undetectable		 1w5uA-4fcsA:
6.25
1w5uB-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 ALA A 167
VAL A 163
TRP A 164
 None
 0.96A 2izqA-4fcsA:
undetectable
2izqB-4fcsA:
undetectable		 2izqA-4fcsA:
6.25
2izqB-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 TRP A 164
ALA A 167
VAL A 163
 None
 0.71A 2izqC-4fcsA:
undetectable
2izqD-4fcsA:
undetectable		 2izqC-4fcsA:
6.25
2izqD-4fcsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 8 SER A 230
PRO A 221
LEU A 222
THR A 240
 HEM  A 401 (-3.5A)
None
None
None
 1.09A 2v0zO-4fcsA:
undetectable		 2v0zO-4fcsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 THR A  73
SER A  86
LYS A  89
 None
 1.08A 3aocC-4fcsA:
undetectable		 3aocC-4fcsA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 8 PHE A 123
VAL A 281
LEU A  17
ARG A 126
 None
 1.03A 3bgdB-4fcsA:
undetectable		 3bgdB-4fcsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  59
GLY A 269
ASP A 135
ASP A  48
 CA  A 402 ( 4.7A)
None
None
None
CA  A 402 (-3.1A)
 0.85A 3ihtA-4fcsA:
undetectable		 3ihtA-4fcsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.05A 3keeA-4fcsA:
undetectable		 3keeA-4fcsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.10A 3keeB-4fcsA:
undetectable		 3keeB-4fcsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.03A 3keeD-4fcsA:
undetectable		 3keeD-4fcsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 TRP A 164
ALA A 167
VAL A 163
 None
 0.90A 3l8lA-4fcsA:
undetectable
3l8lB-4fcsA:
undetectable		 3l8lA-4fcsA:
6.25
3l8lB-4fcsA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 8 ALA A  49
LEU A 268
ASP A  62
SER A  64
 None
None
CA  A 402 (-3.1A)
CA  A 402 (-2.4A)
 1.03A 3qj7A-4fcsA:
undetectable
3qj7D-4fcsA:
undetectable		 3qj7A-4fcsA:
21.97
3qj7D-4fcsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 5 SER A 220
GLY A 183
GLU A  40
GLU A  36
 None
None
HEM  A 401 (-3.2A)
HEM  A 401 (-2.8A)
 1.35A 3raeB-4fcsA:
undetectable
3raeD-4fcsA:
undetectable		 3raeB-4fcsA:
19.72
3raeD-4fcsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.04A 3sueB-4fcsA:
undetectable		 3sueB-4fcsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.02A 3sueD-4fcsA:
undetectable		 3sueD-4fcsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 1.02A 3sufA-4fcsA:
undetectable		 3sufA-4fcsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 11 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
 CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
 0.97A 3sufC-4fcsA:
undetectable		 3sufC-4fcsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 ILE A 103
GLY A 100
GLY A  63
SER A  64
GLY A  59
 None
None
None
CA  A 402 (-2.4A)
None
 0.99A 3uboA-4fcsA:
undetectable		 3uboA-4fcsA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 9 ALA A 167
ILE A 254
GLN A 251
GLY A 117
VAL A 118
 None
 1.14A 4a3uA-4fcsA:
undetectable		 4a3uA-4fcsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 ILE A 254
GLN A 251
GLY A 116
VAL A 118
 None
 1.00A 4a3uB-4fcsA:
undetectable		 4a3uB-4fcsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 VAL A 160
TRP A 164
TRP A 244
GLU A 243
 None
 1.35A 4cwyA-4fcsA:
1.4
4cwyB-4fcsA:
undetectable		 4cwyA-4fcsA:
20.58
4cwyB-4fcsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		3 / 3 ASP A  22
LEU A  21
PHE A  18
 None
 0.49A 4pthA-4fcsA:
undetectable		 4pthA-4fcsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A 176
PHE A  29
ILE A  24
GLY A 107
THR A  45
 HEM  A 401 (-3.4A)
None
None
None
HEM  A 401 ( 4.9A)
 1.28A 5eslA-4fcsA:
undetectable		 5eslA-4fcsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 LEU A  21
PHE A 105
VAL A 109
PRO A 283
ARG A 119
 None
 1.22A 5f9zB-4fcsA:
undetectable		 5f9zB-4fcsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 5 ARG A  43
HIS A  47
ALA A  77
PRO A 141
 HEM  A 401 (-3.9A)
None
None
HEM  A 401 (-4.1A)
 0.86A 5syiA-4fcsA:
23.9		 5syiA-4fcsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.29A 5uo9A-4fcsA:
undetectable
5uo9B-4fcsA:
undetectable		 5uo9A-4fcsA:
20.35
5uo9B-4fcsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.37A 5uo9C-4fcsA:
undetectable
5uo9D-4fcsA:
undetectable		 5uo9C-4fcsA:
20.35
5uo9D-4fcsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.32A 5vvdA-4fcsA:
undetectable
5vvdB-4fcsA:
undetectable		 5vvdA-4fcsA:
20.35
5vvdB-4fcsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 11 PHE A  52
GLY A  51
GLY A  63
GLN A 270
THR A  45
 None
CA  A 402 ( 4.7A)
None
None
HEM  A 401 ( 4.9A)
 1.29A 5x19G-4fcsA:
undetectable
5x19N-4fcsA:
undetectable
5x19O-4fcsA:
undetectable		 5x19G-4fcsA:
10.93
5x19N-4fcsA:
19.30
5x19O-4fcsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 TRP A 164
TRP A 244
GLU A 243
VAL A 160
 None
 1.31A 6av6A-4fcsA:
undetectable
6av6B-4fcsA:
undetectable		 6av6A-4fcsA:
14.92
6av6B-4fcsA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		4 / 7 VAL A 160
TRP A 164
TRP A 244
GLU A 243
 None
 1.32A 6cifC-4fcsA:
undetectable
6cifD-4fcsA:
undetectable		 6cifC-4fcsA:
14.92
6cifD-4fcsA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fcs VERSATILE PEROXIDASE
VPL2
(Pleurotus
eryngii) 		5 / 12 GLY A 176
PHE A  29
ILE A  24
GLY A 107
THR A  45
 HEM  A 401 (-3.4A)
None
None
None
HEM  A 401 ( 4.9A)
 1.23A 6e8qA-4fcsA:
undetectable		 6e8qA-4fcsA:
11.22