SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 VAL B 155
LEU B  62
ALA B  80
SER B  83
LEU B  84
None
1.04A 1eqhB-4fcxB:
undetectable
1eqhB-4fcxB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 LEU B 183
PHE B 158
LEU B 218
PRO B 271
VAL B 269
None
1.41A 1hrkB-4fcxB:
undetectable
1hrkB-4fcxB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 7 HIS B 222
LEU B  62
SER B  24
ASP B  25
MN  B 502 (-3.6A)
None
None
MN  B 501 (-3.3A)
0.72A 1ismB-4fcxB:
undetectable
1ismB-4fcxB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 ASP B  65
HIS B 134
HIS B  27
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
0.45A 1oe1A-4fcxB:
undetectable
1oe1A-4fcxB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 ASP B  65
HIS B 134
HIS B  27
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
0.44A 1oe3A-4fcxB:
undetectable
1oe3A-4fcxB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 ASP B  65
HIS B 134
HIS B  27
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
0.47A 2xxgA-4fcxB:
undetectable
2xxgA-4fcxB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 ASP B  65
HIS B 134
HIS B  27
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
0.48A 2xxgC-4fcxB:
undetectable
2xxgC-4fcxB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 7 PRO B  72
SER B  73
PHE B  42
GLY B  29
None
0.95A 2y7kA-4fcxB:
undetectable
2y7kA-4fcxB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 11 HIS B  27
HIS B 252
HIS B 250
HIS B 222
VAL B 221
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 ( 3.5A)
MN  B 502 (-3.6A)
None
1.14A 2zweA-4fcxB:
undetectable
2zweB-4fcxB:
undetectable
2zweA-4fcxB:
22.09
2zweB-4fcxB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 10 LEU B  61
THR B 220
GLY B 132
HIS B 131
PHE B 158
None
1.28A 3h9uC-4fcxB:
undetectable
3h9uC-4fcxB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 HIS B  68
HIS B  27
HIS B 134
None
MN  B 501 (-3.7A)
None
0.74A 3mihA-4fcxB:
undetectable
3mihA-4fcxB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 VAL B 127
LEU B  62
VAL B  57
ALA B  52
LEU B  49
None
1.28A 3pghA-4fcxB:
undetectable
3pghA-4fcxB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 5 VAL B 127
LEU B  84
LEU B  49
ILE B  66
None
0.82A 4a9jA-4fcxB:
undetectable
4a9jA-4fcxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 5 VAL B 127
LEU B  84
LEU B  49
ILE B  66
None
0.85A 4a9jB-4fcxB:
undetectable
4a9jB-4fcxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 5 VAL B 127
LEU B  84
LEU B  49
ILE B  66
None
0.86A 4a9jC-4fcxB:
undetectable
4a9jC-4fcxB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 GLN B 240
ILE B 186
SER B 170
VAL B 169
ILE B 167
None
0.94A 4ax8A-4fcxB:
undetectable
4ax8A-4fcxB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 10 HIS B 134
ASP B  65
PRO B  26
HIS B  27
GLY B 132
None
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
None
1.48A 4bz6A-4fcxB:
undetectable
4bz6A-4fcxB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 10 HIS B 134
ASP B  65
PRO B  26
HIS B  27
GLY B 132
None
MN  B 502 ( 3.0A)
None
MN  B 501 (-3.7A)
None
1.50A 4bz6D-4fcxB:
undetectable
4bz6D-4fcxB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 8 ASN B 261
PHE B 266
VAL B 246
HIS B 225
None
1.02A 4f5zA-4fcxB:
undetectable
4f5zA-4fcxB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 5 GLY B 159
ILE B 172
LEU B  61
LEU B 234
None
0.85A 4o8fA-4fcxB:
undetectable
4o8fA-4fcxB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 10 VAL B 155
LEU B  62
ALA B  80
SER B  83
LEU B  84
None
1.06A 4ph9A-4fcxB:
undetectable
4ph9A-4fcxB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 10 VAL B 155
LEU B  62
ALA B  80
SER B  83
LEU B  84
None
1.07A 4ph9B-4fcxB:
undetectable
4ph9B-4fcxB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 GLY B 132
ASN B 133
HIS B 134
ILE B 186
THR B 220
None
MN  B 502 (-2.4A)
None
None
None
1.31A 4pooA-4fcxB:
undetectable
4pooA-4fcxB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 5 ILE B 275
SER B 278
HIS B 252
ASP B  69
None
None
MN  B 501 (-3.5A)
None
1.22A 4rzvB-4fcxB:
undetectable
4rzvB-4fcxB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 12 GLY B 132
ASP B 135
PHE B 158
ILE B 130
HIS B 250
None
None
None
None
MN  B 502 ( 3.5A)
1.27A 4wh5A-4fcxB:
undetectable
4wh5A-4fcxB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 6 ASP B  65
ASP B  25
HIS B  27
HIS B 252
HIS B 222
MN  B 502 ( 3.0A)
MN  B 501 (-3.3A)
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 (-3.6A)
1.06A 5ncdA-4fcxB:
undetectable
5ncdD-4fcxB:
undetectable
5ncdA-4fcxB:
20.46
5ncdD-4fcxB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 6 ASP B  65
ASP B  25
HIS B  27
HIS B 252
HIS B 222
MN  B 502 ( 3.0A)
MN  B 501 (-3.3A)
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 (-3.6A)
1.07A 5ncdB-4fcxB:
undetectable
5ncdC-4fcxB:
undetectable
5ncdB-4fcxB:
20.46
5ncdC-4fcxB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 6 ASP B  65
ASP B  25
HIS B  27
HIS B 252
HIS B 222
MN  B 502 ( 3.0A)
MN  B 501 (-3.3A)
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 (-3.6A)
1.04A 5nelA-4fcxB:
undetectable
5nelD-4fcxB:
undetectable
5nelA-4fcxB:
20.46
5nelD-4fcxB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 6 ASP B  65
HIS B  27
HIS B 252
HIS B 222
MN  B 502 ( 3.0A)
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 (-3.6A)
1.01A 5nelB-4fcxB:
undetectable
5nelC-4fcxB:
undetectable
5nelB-4fcxB:
20.46
5nelC-4fcxB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 VAL B 335
TYR B 384
GLN B 385
None
0.47A 5qgkA-4fcxB:
undetectable
5qgkA-4fcxB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 VAL B 335
TYR B 384
GLN B 385
None
0.45A 5qgrA-4fcxB:
undetectable
5qgrA-4fcxB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 VAL B 335
TYR B 384
GLN B 385
None
0.47A 5qgtA-4fcxB:
undetectable
5qgtA-4fcxB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
4 / 8 GLU B 283
PHE B  45
SER B 129
LEU B  84
None
1.00A 5y2tB-4fcxB:
undetectable
5y2tB-4fcxB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 11 HIS B  27
HIS B 252
HIS B 250
HIS B 222
VAL B 221
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 ( 3.5A)
MN  B 502 (-3.6A)
None
1.18A 5z0fA-4fcxB:
undetectable
5z0fB-4fcxB:
undetectable
5z0fA-4fcxB:
10.22
5z0fB-4fcxB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 11 HIS B  27
HIS B 252
HIS B 250
HIS B 222
VAL B 221
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 ( 3.5A)
MN  B 502 (-3.6A)
None
1.14A 5z0gA-4fcxB:
undetectable
5z0gB-4fcxB:
undetectable
5z0gA-4fcxB:
10.22
5z0gB-4fcxB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
5 / 11 HIS B  27
HIS B 252
HIS B 250
HIS B 222
VAL B 221
MN  B 501 (-3.7A)
MN  B 501 (-3.5A)
MN  B 502 ( 3.5A)
MN  B 502 (-3.6A)
None
1.16A 5z0jA-4fcxB:
undetectable
5z0jB-4fcxB:
undetectable
5z0jA-4fcxB:
10.22
5z0jB-4fcxB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomy
ces
pombe)
3 / 3 TYR B 243
ASP B 241
GLN B 240
None
0.88A 6g1pA-4fcxB:
undetectable
6g1pA-4fcxB:
20.24