SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 193
THR A 217
PRO A 192
 None
 0.80A 1a7yB-4fd0A:
undetectable		 1a7yB-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 CYH A 322
LEU A 282
LEU A 255
VAL A 303
ILE A 277
 None
 1.39A 1ee2A-4fd0A:
undetectable		 1ee2A-4fd0A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 CYH A 322
LEU A 282
LEU A 255
VAL A 303
ILE A 277
 None
 1.38A 1ee2B-4fd0A:
undetectable		 1ee2B-4fd0A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 193
 None
 0.85A 1i3wE-4fd0A:
undetectable		 1i3wE-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 194
THR A 217
PRO A 192
 None
 0.86A 1i3wE-4fd0A:
undetectable		 1i3wE-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 193
 None
 0.84A 1i3wG-4fd0A:
undetectable		 1i3wG-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 193
THR A 217
PRO A 192
 None
 0.84A 1qfiB-4fd0A:
undetectable		 1qfiB-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 193
 None
 0.75A 1unjF-4fd0A:
undetectable		 1unjF-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.86A 1unjF-4fd0A:
undetectable		 1unjF-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 193
THR A 217
PRO A 192
 None
 0.79A 1unjF-4fd0A:
undetectable		 1unjF-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 193
 None
 0.86A 1unjL-4fd0A:
undetectable		 1unjL-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.87A 1unjL-4fd0A:
undetectable		 1unjL-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.87A 1unjR-4fd0A:
undetectable		 1unjR-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 194
THR A 217
PRO A 192
 None
 0.85A 1unjW-4fd0A:
undetectable		 1unjW-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 193
 None
 0.86A 1unjX-4fd0A:
undetectable		 1unjX-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.83A 1unmE-4fd0A:
undetectable		 1unmE-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 10 ILE A 154
ALA A 180
VAL A 186
VAL A 167
ILE A 164
 None
 1.01A 2nnjA-4fd0A:
undetectable		 2nnjA-4fd0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.77A 316dC-4fd0A:
undetectable		 316dC-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 7 ILE A 258
ILE A 318
LEU A 255
LEU A 329
 None
 0.56A 3adxA-4fd0A:
undetectable		 3adxA-4fd0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 9 LEU A 300
ILE A 277
GLY A 276
LEU A 323
GLU A 274
 None
 0.97A 3ai9X-4fd0A:
undetectable		 3ai9X-4fd0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 PHE A 294
VAL A 228
VAL A 280
LEU A 282
ILE A 258
 None
 1.42A 3elzA-4fd0A:
undetectable		 3elzA-4fd0A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 VAL A 361
ALA A 359
MET A 378
THR A 305
ILE A 334
 None
SO4  A 508 (-3.5A)
None
None
None
 1.21A 3qfxB-4fd0A:
undetectable		 3qfxB-4fd0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 7 PHE A 369
GLY A 342
ILE A 334
PHE A 332
 None
 0.81A 4ejjA-4fd0A:
undetectable		 4ejjA-4fd0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 ALA A 224
ILE A 244
LEU A 222
LYS A 221
 SO4  A 512 (-3.2A)
None
None
SO4  A 512 (-3.2A)
 1.22A 4g19A-4fd0A:
undetectable		 4g19A-4fd0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 ILE A 260
ILE A 244
ALA A 293
ILE A 277
VAL A 280
 None
 0.89A 4h1nA-4fd0A:
undetectable		 4h1nA-4fd0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		3 / 3 THR A 217
PRO A 192
THR A 194
 None
 0.82A 4hivD-4fd0A:
undetectable		 4hivD-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.13A 5iy5P-4fd0A:
undetectable
5iy5W-4fd0A:
undetectable		 5iy5P-4fd0A:
20.50
5iy5W-4fd0A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 LEU A 222
ALA A 248
LEU A 300
ILE A 260
LEU A 323
 None
 1.03A 5ljeA-4fd0A:
undetectable		 5ljeA-4fd0A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 12 LEU A 222
ALA A 248
LEU A 300
PHE A 227
LEU A 323
 None
 1.11A 5ljeA-4fd0A:
undetectable		 5ljeA-4fd0A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 6 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.11A 5w97C-4fd0A:
undetectable
5w97J-4fd0A:
undetectable		 5w97C-4fd0A:
20.25
5w97J-4fd0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.04A 5x1fC-4fd0A:
undetectable
5x1fJ-4fd0A:
undetectable		 5x1fC-4fd0A:
20.25
5x1fJ-4fd0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.10A 5xdxC-4fd0A:
undetectable
5xdxJ-4fd0A:
undetectable		 5xdxC-4fd0A:
20.25
5xdxJ-4fd0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		4 / 5 LEU A 300
PHE A 272
LEU A 323
PHE A 332
 None
 1.13A 5xdxP-4fd0A:
undetectable
5xdxW-4fd0A:
undetectable		 5xdxP-4fd0A:
20.25
5xdxW-4fd0A:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 10 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
 None
SO4  A 512 ( 4.3A)
None
None
None
 1.20A 6ebpB-4fd0A:
undetectable		 6ebpB-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 10 PHE A 294
LEU A 323
ILE A 267
PHE A 332
ILE A 318
 None
 1.14A 6ebpB-4fd0A:
undetectable		 6ebpB-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 10 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
 None
SO4  A 512 ( 4.3A)
None
None
None
 1.22A 6ebpC-4fd0A:
undetectable		 6ebpC-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 10 PHE A 294
LEU A 323
ILE A 267
PHE A 332
ILE A 318
 None
 1.11A 6ebpC-4fd0A:
undetectable		 6ebpC-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 PHE A 294
LEU A 323
ILE A 267
PHE A 332
ILE A 318
 None
 1.09A 6ebzD-4fd0A:
undetectable		 6ebzD-4fd0A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
 None
SO4  A 512 ( 4.3A)
None
None
None
 1.02A 6gp2A-4fd0A:
undetectable		 6gp2A-4fd0A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN
(Bacteroides
caccae) 		5 / 11 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
 None
SO4  A 512 ( 4.3A)
None
None
None
 1.01A 6gp2B-4fd0A:
undetectable		 6gp2B-4fd0A:
11.66