SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		3 / 3 GLU A  49
HIS A  44
HIS A  25
 None
 0.69A 1oe2A-4fd4A:
undetectable		 1oe2A-4fd4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		5 / 12 SER A  76
LEU A 132
PHE A 167
MET A 181
GLY A 180
 None
 1.46A 4j7xA-4fd4A:
undetectable		 4j7xA-4fd4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		5 / 12 SER A  76
LEU A 132
PHE A 167
MET A 181
GLY A 180
 None
 1.47A 4j7xF-4fd4A:
undetectable		 4j7xF-4fd4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		5 / 9 LEU A 132
LEU A 143
GLY A 144
LEU A 147
ALA A  64
 None
 0.86A 5dqfA-4fd4A:
undetectable		 5dqfA-4fd4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		4 / 8 TYR A  28
PHE A  55
SER A 164
SER A  54
 GOL  A 302 ( 4.9A)
None
None
None
 1.06A 5l1fA-4fd4A:
undetectable
5l1fB-4fd4A:
undetectable		 5l1fA-4fd4A:
13.96
5l1fB-4fd4A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		5 / 12 VAL A 117
ASP A 116
ALA A 126
SER A 164
GLY A  84
 GOL  A 301 (-4.3A)
GOL  A 301 ( 4.7A)
None
None
None
 1.15A 5m54E-4fd4A:
undetectable		 5m54E-4fd4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B
(Aedes
aegypti) 		3 / 3 ARG A  13
PHE A  72
ARG A  10
 None
 1.17A 5y9yA-4fd4A:
undetectable		 5y9yA-4fd4A:
23.60