SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fd7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		4 / 7 ILE A 129
TYR A 126
PHE A 122
PHE A 117
 None
 0.95A 1e71M-4fd7A:
undetectable		 1e71M-4fd7A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		4 / 7 ILE A 129
TYR A 126
PHE A 122
PHE A 117
 None
 0.95A 1e72M-4fd7A:
undetectable		 1e72M-4fd7A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		3 / 3 ARG A  92
SER A  95
TYR A 159
 None
 0.97A 2q2hA-4fd7A:
undetectable
2q2hB-4fd7A:
undetectable		 2q2hA-4fd7A:
21.74
2q2hB-4fd7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		4 / 8 LEU A 175
VAL A 237
TRP A   3
LEU A 148
 None
 0.89A 3v81C-4fd7A:
undetectable		 3v81C-4fd7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		5 / 12 PHE A 202
LEU A 183
ILE A 138
TYR A 147
ALA A 150
 None
 1.26A 4a83A-4fd7A:
undetectable		 4a83A-4fd7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		4 / 7 SER A 154
TYR A  51
VAL A 101
TRP A  78
 None
 1.42A 4l64A-4fd7A:
undetectable		 4l64A-4fd7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		5 / 10 PHE A  18
ALA A 165
VAL A 155
TYR A 159
GLY A 163
 None
 1.31A 4xp1A-4fd7A:
0.6		 4xp1A-4fd7A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		5 / 11 VAL A 101
GLY A 100
ASP A  43
ALA A  44
LEU A  36
 None
None
IOD  A 301 ( 4.6A)
None
None
 1.02A 5x6yA-4fd7A:
undetectable		 5x6yA-4fd7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4fd7 PUTATIVE
ARYLALKYLAMINE
N-ACETYLTRANSFERASE
7
(Aedes
aegypti) 		5 / 10 VAL A 101
GLY A 100
ASP A  43
ALA A  44
LEU A  36
 None
None
IOD  A 301 ( 4.6A)
None
None
 1.01A 5x6yB-4fd7A:
undetectable		 5x6yB-4fd7A:
14.50