SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 150
PRO A 148
THR A 152
 None
 0.68A 209dC-4fdaA:
undetectable		 209dC-4fdaA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  63
ILE A   8
THR A  10
LEU A 117
CYH A 155
 None
 1.16A 2qo5A-4fdaA:
undetectable		 2qo5A-4fdaA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 181
ASN A 144
SER A 201
SER A 183
 None
None
None
NAP  A 301 (-3.3A)
 1.14A 2zw9B-4fdaA:
undetectable		 2zw9B-4fdaA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  11
ALA A  12
ILE A  33
LEU A  98
ILE A   8
 NAP  A 301 (-3.0A)
None
None
None
None
 0.84A 4dt8A-4fdaA:
undetectable		 4dt8A-4fdaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A   8
ILE A  20
GLY A  17
GLY A  11
LEU A 116
 None
None
None
NAP  A 301 (-3.0A)
None
 0.84A 5twjA-4fdaA:
undetectable		 5twjA-4fdaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 142
VAL A 197
SER A 201
TYR A 198
 None
None
None
NAP  A 301 (-3.6A)
 1.13A 6huoC-4fdaA:
undetectable
6huoD-4fdaA:
undetectable		 6huoC-4fdaA:
14.29
6huoD-4fdaA:
18.14