SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.37A 1c9sA-4fddA:
undetectable
1c9sB-4fddA:
undetectable		 1c9sA-4fddA:
6.80
1c9sB-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 5 THR A 774
GLU A 734
THR A 695
LEU A 713
 None
 1.39A 1d4fC-4fddA:
undetectable		 1d4fC-4fddA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 8 PHE A 814
GLY A 816
VAL A 828
PHE A 853
 None
 0.94A 1gsfC-4fddA:
3.9		 1gsfC-4fddA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.37A 1gtnG-4fddA:
undetectable
1gtnH-4fddA:
undetectable		 1gtnG-4fddA:
6.80
1gtnH-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		6 / 9 ALA A 423
ILE A 398
VAL A 305
GLY A 417
ILE A 418
ILE A 424
 None
 1.15A 1hshB-4fddA:
undetectable		 1hshB-4fddA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 11 LEU A 293
VAL A 389
TRP A 280
LEU A 283
PRO A 287
 None
 1.23A 1klmA-4fddA:
undetectable		 1klmA-4fddA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 GLU A 653
ARG B 518
ASP A 550
GLY B 515
 None
 0.92A 1mt1H-4fddA:
undetectable
1mt1K-4fddA:
undetectable		 1mt1H-4fddA:
8.42
1mt1K-4fddA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		3 / 3 ASP A 646
LEU A 647
HIS A 554
 None
 0.76A 1qknA-4fddA:
undetectable		 1qknA-4fddA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 645
LEU A 648
LEU A 651
ALA A 652
TYR A 609
 None
 0.59A 1s9pC-4fddA:
undetectable		 1s9pC-4fddA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		5 / 10 LEU A 402
ILE A 301
LEU A 394
TYR B 526
THR A 461
 None
 1.40A 1tdrB-4fddA:
undetectable		 1tdrB-4fddA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.38A 1utdD-4fddA:
undetectable
1utdE-4fddA:
undetectable		 1utdD-4fddA:
6.80
1utdE-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.36A 1utdG-4fddA:
undetectable
1utdH-4fddA:
undetectable		 1utdG-4fddA:
6.80
1utdH-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.38A 1utdA-4fddA:
undetectable
1utdK-4fddA:
undetectable		 1utdA-4fddA:
6.80
1utdK-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 645
LEU A 648
LEU A 651
ALA A 652
LEU A 669
 None
 0.98A 1ya3C-4fddA:
undetectable		 1ya3C-4fddA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 GLY A 422
VAL A 454
ARG A 376
HIS A 442
ILE A 440
 None
 1.47A 1z95A-4fddA:
undetectable		 1z95A-4fddA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 LEU A  16
GLN A  17
LEU A  57
PHE A  52
 None
 1.00A 2dysP-4fddA:
undetectable
2dysW-4fddA:
undetectable		 2dysP-4fddA:
15.94
2dysW-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 10 LEU A 436
MET A 432
LEU A 439
HIS A 442
THR A 458
 None
 1.47A 2idkA-4fddA:
0.0
2idkB-4fddA:
0.0
2idkC-4fddA:
0.0
2idkD-4fddA:
0.2		 2idkA-4fddA:
15.75
2idkB-4fddA:
15.75
2idkC-4fddA:
15.75
2idkD-4fddA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 5 ALA A 381
TRP A 373
LEU A 375
ALA A 382
 None
 1.29A 2jstA-4fddA:
undetectable
2jstB-4fddA:
undetectable		 2jstA-4fddA:
5.98
2jstB-4fddA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 ALA A 505
THR A 547
ILE A 522
PHE A 530
LEU A 490
 None
 1.10A 2nyrA-4fddA:
undetectable		 2nyrA-4fddA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
RNA-BINDING PROTEIN
FUS
(Homo
sapiens;
Homo
sapiens) 		4 / 7 MET A 308
ILE A 398
PRO B 525
TRP A 460
 None
 1.20A 2pnjB-4fddA:
undetectable		 2pnjB-4fddA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 MET A 432
LEU A 439
LEU A 402
LEU A 383
VAL A 305
 None
 1.19A 2po7B-4fddA:
undetectable		 2po7B-4fddA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		6 / 12 ALA A 423
ILE A 398
VAL A 305
GLY A 417
ILE A 418
ILE A 424
 None
 1.32A 2rkgA-4fddA:
undetectable		 2rkgA-4fddA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 TYR A 465
LEU A 395
ALA A 387
LEU A 383
ALA A 423
 None
 1.12A 2vcvD-4fddA:
3.4		 2vcvD-4fddA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 9 TYR A 465
LEU A 395
ALA A 387
LEU A 383
ALA A 423
 None
 1.16A 2vcvI-4fddA:
1.7		 2vcvI-4fddA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 10 MET A 676
ALA A 728
ALA A 731
THR A 695
VAL A 702
 None
 1.34A 2wuzA-4fddA:
undetectable		 2wuzA-4fddA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 10 MET A 676
ALA A 728
ALA A 731
THR A 695
VAL A 702
 None
 1.31A 2wuzB-4fddA:
undetectable		 2wuzB-4fddA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ASN A 727
SER A 686
ALA A 689
ASP B 512
 None
 1.37A 3aruA-4fddA:
undetectable		 3aruA-4fddA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 8 TYR A 260
VAL A 272
CYH A 236
ARG A 264
 None
 1.00A 3b9lA-4fddA:
undetectable		 3b9lA-4fddA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ASN A 807
ILE A 804
GLU A 809
LYS B 507
 None
 1.20A 3kp6A-4fddA:
1.4
3kp6B-4fddA:
undetectable		 3kp6A-4fddA:
10.71
3kp6B-4fddA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		3 / 3 SER A 841
ASP A 806
ASN A 807
 None
 0.81A 3lsfB-4fddA:
undetectable
3lsfE-4fddA:
undetectable		 3lsfB-4fddA:
14.22
3lsfE-4fddA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		3 / 3 ASP A 806
ASN A 807
SER A 841
 None
 0.88A 3lsfB-4fddA:
undetectable
3lsfE-4fddA:
undetectable		 3lsfB-4fddA:
14.22
3lsfE-4fddA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 10 ILE A 735
MET A 710
GLY A 714
VAL A 786
LEU A 778
 None
 0.94A 3ogpA-4fddA:
undetectable		 3ogpA-4fddA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		5 / 11 ARG A 464
LEU A 383
TYR B 526
LEU A 419
ALA A 425
 None
 1.27A 3pghB-4fddA:
1.3		 3pghB-4fddA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		5 / 11 ARG A 464
LEU A 383
TYR B 526
LEU A 419
GLY A 427
 None
 1.16A 3pghB-4fddA:
1.3		 3pghB-4fddA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 ASP A 837
ILE A 794
ASP A 806
ILE A 843
PHE A 814
 None
 1.12A 3phaB-4fddA:
undetectable		 3phaB-4fddA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 5 SER A 591
GLY A 692
GLU A 809
GLU A 734
 None
 1.41A 3raeB-4fddA:
undetectable
3raeD-4fddA:
undetectable		 3raeB-4fddA:
20.89
3raeD-4fddA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 1.04A 3wg7N-4fddA:
3.2
3wg7W-4fddA:
undetectable		 3wg7N-4fddA:
20.07
3wg7W-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 GLU A 230
LYS A 189
PRO A 188
GLU A 228
 None
 1.34A 4a7uA-4fddA:
undetectable		 4a7uA-4fddA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ASP A 314
SER A 311
ARG A 376
GLU A 415
 None
 1.13A 4eysA-4fddA:
undetectable		 4eysA-4fddA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
RNA-BINDING PROTEIN
FUS
(Homo
sapiens;
Homo
sapiens) 		4 / 8 MET A 308
ILE A 398
PRO B 525
TRP A 460
 None
 1.21A 4f4dB-4fddA:
undetectable		 4f4dB-4fddA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 645
LEU A 648
LEU A 651
ALA A 652
LEU A 669
 None
 1.02A 4ltwA-4fddA:
undetectable		 4ltwA-4fddA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 VAL A 593
LEU A 597
LEU A 565
PHE A 504
 None
 1.03A 4o1zA-4fddA:
1.8		 4o1zA-4fddA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 GLY A 147
ALA A 148
GLY A 150
LEU A 152
GLY A 111
 None
 0.86A 4o3fA-4fddA:
undetectable		 4o3fA-4fddA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 GLN A 753
LEU A 754
THR A 729
LEU A 713
GLY A 714
 None
 1.19A 4o5fA-4fddA:
undetectable
4o5fB-4fddA:
undetectable		 4o5fA-4fddA:
15.23
4o5fB-4fddA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 ILE A  91
THR A 144
ALA A 148
ALA A 151
TRP A 126
 None
 1.16A 4u14A-4fddA:
2.1		 4u14A-4fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.77A 5b1aA-4fddA:
3.3
5b1aJ-4fddA:
undetectable		 5b1aA-4fddA:
20.07
5b1aJ-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.77A 5b3sA-4fddA:
2.3
5b3sJ-4fddA:
undetectable		 5b3sA-4fddA:
20.07
5b3sJ-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 713
GLY A 714
GLN A 753
LEU A 754
THR A 729
 None
 1.19A 5b8hA-4fddA:
undetectable
5b8hB-4fddA:
undetectable		 5b8hA-4fddA:
15.36
5b8hB-4fddA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 GLN A 753
LEU A 754
THR A 729
LEU A 713
GLY A 714
 None
 1.17A 5b8hA-4fddA:
undetectable
5b8hB-4fddA:
undetectable		 5b8hA-4fddA:
15.36
5b8hB-4fddA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		6 / 12 ALA A 423
ILE A 398
VAL A 305
GLY A 417
ILE A 418
ILE A 424
 None
 1.35A 5e5kA-4fddA:
undetectable		 5e5kA-4fddA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ALA A 284
VAL A 389
TYR A 390
VAL A 292
 None
 1.07A 5eckA-4fddA:
undetectable		 5eckA-4fddA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ALA A 284
VAL A 389
TYR A 390
VAL A 292
 None
 1.07A 5eckD-4fddA:
undetectable		 5eckD-4fddA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 569
ILE A 562
GLU A 508
ALA A 549
LEU A 597
 None
 1.04A 5ienB-4fddA:
undetectable		 5ienB-4fddA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 4 PHE A 834
ILE A 833
GLN A 830
ARG A 795
 None
 1.45A 5jm4B-4fddA:
3.0		 5jm4B-4fddA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 ILE A 758
ILE A 747
VAL A 750
LEU A 751
VAL A 755
 None
 0.97A 5mueA-4fddA:
undetectable		 5mueA-4fddA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 8 LYS A 414
THR A 458
THR A 461
TYR A 465
 None
 1.15A 5x2sI-4fddA:
undetectable
5x2sJ-4fddA:
undetectable
5x2sK-4fddA:
undetectable		 5x2sI-4fddA:
10.40
5x2sJ-4fddA:
10.69
5x2sK-4fddA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 HIS A 858
ASP A 866
GLY A 865
ASN A 862
 None
 1.01A 5x7pA-4fddA:
undetectable		 5x7pA-4fddA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 5 HIS A 858
ASP A 866
GLY A 865
ASN A 862
 None
 1.05A 5x7pB-4fddA:
undetectable		 5x7pB-4fddA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 1.02A 5z86N-4fddA:
undetectable
5z86W-4fddA:
undetectable		 5z86N-4fddA:
20.07
5z86W-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 1.04A 5zcoN-4fddA:
3.1
5zcoW-4fddA:
undetectable		 5zcoN-4fddA:
20.07
5zcoW-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.76A 5zcpA-4fddA:
2.5
5zcpJ-4fddA:
undetectable		 5zcpA-4fddA:
20.07
5zcpJ-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 7 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.81A 5zcqA-4fddA:
1.6
5zcqJ-4fddA:
undetectable		 5zcqA-4fddA:
20.07
5zcqJ-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 8 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.89A 5zcqN-4fddA:
2.5
5zcqW-4fddA:
undetectable		 5zcqN-4fddA:
20.07
5zcqW-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		5 / 12 ILE A 444
LEU A 485
LEU A 462
ALA A 466
LEU A 507
 None
 0.81A 6ajiA-4fddA:
undetectable		 6ajiA-4fddA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4fdd RNA-BINDING PROTEIN
FUS
(Homo
sapiens) 		3 / 3 ARG B 518
HIS B 517
ARG B 521
 None
 1.09A 6dwdD-4fddB:
undetectable		 6dwdD-4fddB:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 5 LEU A 293
LEU A 304
THR A 282
ARG A 232
 None
 1.05A 6ew0F-4fddA:
1.8		 6ew0F-4fddA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4fdd TRANSPORTIN-1
(Homo
sapiens) 		4 / 6 LEU A 293
LEU A 304
THR A 282
ARG A 232
 None
 1.05A 6ew0G-4fddA:
1.9		 6ew0G-4fddA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens) 		3 / 3 ASP B 520
ASP B 512
ASN A 770
 None
 0.86A 6gngB-4fddB:
undetectable		 6gngB-4fddB:
4.35