SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 4fdf MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C 2
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 151
MET A 122
GLU A 123
ALA A 124
VAL A 128
 None
 1.22A 1ctrA-4fdfA:
undetectable		 1ctrA-4fdfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4fdf MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C 2
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  66
ILE A  55
ALA A  69
ILE A 148
 None
 0.89A 1oniB-4fdfA:
undetectable
1oniC-4fdfA:
undetectable		 1oniB-4fdfA:
25.84
1oniC-4fdfA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fdf MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C 2
(Mycobacterium
tuberculosis) 		4 / 8 SER A  56
ARG A  70
ILE A  55
PHE A  99
 None
 1.28A 4cx7A-4fdfA:
undetectable
4cx7B-4fdfA:
undetectable		 4cx7A-4fdfA:
17.70
4cx7B-4fdfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4fdf MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  64
PHE A  99
ARG A  70
 None
 1.10A 5yw0A-4fdfA:
undetectable		 5yw0A-4fdfA:
20.37