SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		3 / 3 GLU B 160
ILE B 190
ARG B  99
 None
 0.85A 1cd2A-4fdgB:
undetectable		 1cd2A-4fdgB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 ARG B 355
ILE B 417
ASP B 413
GLY B 372
SER B 368
 None
 1.44A 1q8jA-4fdgB:
undetectable		 1q8jA-4fdgB:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 6 ARG B 567
THR B 582
ALA B 532
PRO B 526
 None
 1.44A 2ql8A-4fdgB:
undetectable
2ql8B-4fdgB:
undetectable		 2ql8A-4fdgB:
12.39
2ql8B-4fdgB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 THR B 425
ASN B 438
VAL B 394
GLY B 228
ALA B 390
 None
 1.07A 2x2iA-4fdgB:
undetectable		 2x2iA-4fdgB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 THR B 425
ASN B 438
VAL B 394
GLY B 228
ALA B 390
 None
 1.13A 2x2iC-4fdgB:
undetectable		 2x2iC-4fdgB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 9 LEU B 120
SER B 261
ILE B 236
ILE B  73
GLY B  76
 None
 0.97A 3cv9A-4fdgB:
undetectable		 3cv9A-4fdgB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		3 / 3 CYH B 171
CYH B 149
HIS B 144
 ZN  B 701 (-2.1A)
ZN  B 701 (-2.3A)
ZN  B 701 (-3.2A)
 0.76A 3dtuB-4fdgB:
undetectable		 3dtuB-4fdgB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		3 / 3 CYH B 171
CYH B 149
HIS B 144
 ZN  B 701 (-2.1A)
ZN  B 701 (-2.3A)
ZN  B 701 (-3.2A)
 0.76A 3dtuD-4fdgB:
undetectable		 3dtuD-4fdgB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 ILE B 126
GLY B 228
ARG B 226
ASP B 229
ALA B 390
 None
 1.11A 3jb1A-4fdgB:
undetectable		 3jb1A-4fdgB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 5 PHE B 478
MET B 593
ASN B 591
PHE B 474
 None
 1.36A 3octA-4fdgB:
undetectable		 3octA-4fdgB:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 11 ALA B 401
ILE B 126
GLY B 391
ALA B 392
VAL B 426
 None
 1.09A 3rukD-4fdgB:
undetectable		 3rukD-4fdgB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 6 LEU B 373
ILE B 406
THR B 363
GLY B 367
 None
 1.02A 4l39A-4fdgB:
undetectable		 4l39A-4fdgB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 LEU B 120
GLY B 118
MET B 257
VAL B 259
ILE B 112
 None
 1.32A 4oktA-4fdgB:
undetectable		 4oktA-4fdgB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 SER B 368
ASP B 404
ILE B 403
ALA B 401
VAL B 443
 None
 1.06A 4u8yB-4fdgB:
3.3		 4u8yB-4fdgB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 SER B 368
ASP B 404
ILE B 403
ALA B 401
VAL B 443
 None
 1.05A 4u95B-4fdgB:
2.8		 4u95B-4fdgB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 5 ALA B 573
ARG B 588
ALA B 314
GLU B 311
 None
 1.35A 5a06C-4fdgB:
undetectable
5a06D-4fdgB:
undetectable		 5a06C-4fdgB:
20.20
5a06D-4fdgB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 12 LEU B 221
THR B  67
LEU B  71
ILE B  93
VAL B 233
 None
 1.32A 5dlvB-4fdgB:
undetectable		 5dlvB-4fdgB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 5 PRO B 104
LEU B  74
TYR B  30
PHE B  21
 None
 1.28A 5igjA-4fdgB:
undetectable		 5igjA-4fdgB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		4 / 6 SER B 347
GLY B 447
ASN B 448
ILE B 403
 None
 0.91A 5j4nA-4fdgB:
undetectable		 5j4nA-4fdgB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 11 ALA B 396
VAL B 426
ILE B 417
ALA B 416
ALA B 371
 None
 1.09A 6h1lB-4fdgB:
undetectable		 6h1lB-4fdgB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		5 / 11 ALA B 439
ALA B 420
GLY B 398
GLY B 399
ALA B 396
 None
 0.94A 6hwdY-4fdgB:
undetectable
6hwdZ-4fdgB:
undetectable		 6hwdY-4fdgB:
8.91
6hwdZ-4fdgB:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM
(Sulfolobus
solfataricus) 		3 / 3 ARG B 583
LEU B 535
PHE B 539
 None
 0.70A 6nknP-4fdgB:
undetectable		 6nknP-4fdgB:
15.03