SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 327
LEU A 330
GLN A 337
ARG A 341
LEU A 186
 None
 1.44A 1a28A-4fdhA:
undetectable		 1a28A-4fdhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.20A 1a28B-4fdhA:
undetectable		 1a28B-4fdhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 263
PHE A 231
PHE A 487
PHE A 130
 None
0T3  A 602 ( 4.9A)
0T3  A 602 (-4.8A)
0T3  A 602 (-4.0A)
 1.26A 1e71M-4fdhA:
undetectable		 1e71M-4fdhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 263
PHE A 231
PHE A 487
PHE A 130
 None
0T3  A 602 ( 4.9A)
0T3  A 602 (-4.8A)
0T3  A 602 (-4.0A)
 1.25A 1e72M-4fdhA:
undetectable		 1e72M-4fdhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 463
PHE A 168
VAL A 164
VAL A 212
 None
 0.79A 1epbB-4fdhA:
undetectable		 1epbB-4fdhA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 369
THR A 326
LEU A 330
VAL A 467
 None
 0.86A 1jgsA-4fdhA:
undetectable		 1jgsA-4fdhA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 340
GLU A 343
HIS A 465
LEU A 362
HIS A 466
 None
 1.49A 1mjlA-4fdhA:
undetectable
1mjlB-4fdhA:
0.1		 1mjlA-4fdhA:
12.24
1mjlB-4fdhA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 128
ARG A 448
PHE A 130
ILE A 263
PHE A 264
 None
HEM  A 601 (-3.8A)
0T3  A 602 (-4.0A)
None
None
 1.28A 1p93D-4fdhA:
undetectable		 1p93D-4fdhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
ARG A 341
 None
 0.78A 1s9pC-4fdhA:
undetectable		 1s9pC-4fdhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASP A 147
LEU A 294
LEU A 295
LEU A 293
 None
 1.25A 1u18A-4fdhA:
undetectable		 1u18A-4fdhA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.19A 1ya3A-4fdhA:
undetectable		 1ya3A-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.13A 1ya3C-4fdhA:
undetectable		 1ya3C-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
LEU A 186
 None
 1.12A 1ya3C-4fdhA:
undetectable		 1ya3C-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.14A 1zucB-4fdhA:
undetectable		 1zucB-4fdhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.13A 2aa5B-4fdhA:
undetectable		 2aa5B-4fdhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.10A 2aa6A-4fdhA:
undetectable		 2aa6A-4fdhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.15A 2oaxB-4fdhA:
undetectable		 2oaxB-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.18A 2oaxD-4fdhA:
undetectable		 2oaxD-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.10A 2oaxE-4fdhA:
undetectable		 2oaxE-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 120
ASN A 269
THR A 312
 0T3  A 602 (-3.9A)
None
None
 0.89A 2q63A-4fdhA:
undetectable		 2q63A-4fdhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.13A 2w8yB-4fdhA:
undetectable		 2w8yB-4fdhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A 314
ALA A 456
PHE A 321
THR A 196
ARG A 490
 0T3  A 602 ( 3.3A)
HEM  A 601 ( 3.8A)
None
None
None
 1.33A 3a3yA-4fdhA:
undetectable		 3a3yA-4fdhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A 230
PHE A 223
PHE A 264
LEU A 132
GLU A 302
 None
 1.17A 3aocC-4fdhA:
undetectable		 3aocC-4fdhA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
GLN A 337
ARG A 341
LEU A 186
 None
 1.32A 3d90A-4fdhA:
undetectable		 3d90A-4fdhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.17A 3d90A-4fdhA:
undetectable		 3d90A-4fdhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.15A 4fn9A-4fdhA:
undetectable		 4fn9A-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.14A 4fn9B-4fdhA:
undetectable		 4fn9B-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 331
LEU A 330
VAL A 467
LEU A 464
ILE A 192
 None
 1.00A 4g1bA-4fdhA:
undetectable		 4g1bA-4fdhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.12A 4ltwA-4fdhA:
undetectable		 4ltwA-4fdhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 172
LEU A 464
LEU A 323
LEU A 186
PHE A 168
 None
 0.87A 4odoA-4fdhA:
undetectable		 4odoA-4fdhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 172
LEU A 464
LEU A 323
LEU A 186
PHE A 168
 None
 0.87A 4odoB-4fdhA:
undetectable		 4odoB-4fdhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 172
LEU A 464
LEU A 323
LEU A 186
PHE A 168
 None
 0.87A 4odoC-4fdhA:
undetectable		 4odoC-4fdhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 223
LEU A 224
GLY A 210
LEU A 209
VAL A 316
 None
 1.11A 4wnwB-4fdhA:
34.9		 4wnwB-4fdhA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 239
LEU A 113
PRO A 115
ARG A  51
 None
 1.16A 4yv5B-4fdhA:
undetectable		 4yv5B-4fdhA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 239
LEU A 113
PRO A 115
ARG A  51
 None
 1.21A 4yv5A-4fdhA:
undetectable		 4yv5A-4fdhA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A  77
LEU A  93
VAL A 405
PHE A 417
LEU A 416
 None
 1.46A 5cymA-4fdhA:
undetectable		 5cymA-4fdhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A  77
LEU A  93
VAL A 405
PHE A 417
LEU A 416
 None
 1.46A 5cyqA-4fdhA:
undetectable		 5cyqA-4fdhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 340
PRO A 495
LEU A 324
ASN A 333
LEU A 464
 None
 1.44A 5emlA-4fdhA:
undetectable		 5emlA-4fdhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 322
THR A 475
ILE A 481
SER A 494
PHE A 328
 None
 1.35A 5hgcA-4fdhA:
undetectable		 5hgcA-4fdhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 204
ILE A 263
GLU A 459
THR A 319
LEU A 227
 None
None
None
HEM  A 601 (-4.6A)
None
 1.05A 5ienB-4fdhA:
undetectable		 5ienB-4fdhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 469
HIS A 466
HIS A 470
 None
 1.40A 5oexA-4fdhA:
undetectable		 5oexA-4fdhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 469
HIS A 466
HIS A 470
 None
 1.41A 5oexB-4fdhA:
undetectable		 5oexB-4fdhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 469
HIS A 466
HIS A 470
 None
 1.39A 5oexC-4fdhA:
undetectable		 5oexC-4fdhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A  77
LEU A  93
ILE A 397
LEU A 402
THR A 401
 None
 1.05A 5tiwB-4fdhA:
undetectable		 5tiwB-4fdhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A  77
LEU A  93
VAL A 405
PHE A 417
LEU A 416
 None
 1.48A 6eliA-4fdhA:
undetectable		 6eliA-4fdhA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 281
PRO A 283
GLN A 284
 None
 0.83A 6jnhA-4fdhA:
undetectable		 6jnhA-4fdhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 281
PRO A 283
GLN A 284
 None
 0.82A 6jogA-4fdhA:
undetectable		 6jogA-4fdhA:
20.40