SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		3 / 3 VAL A 138
VAL A 232
TRP A 159
 None
 0.81A 1bdwA-4fdjA:
undetectable
1bdwB-4fdjA:
undetectable		 1bdwA-4fdjA:
2.94
1bdwB-4fdjA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 PHE A 402
LEU A 390
ILE A 382
ALA A 393
ALA A 400
 None
 1.03A 1cbsA-4fdjA:
undetectable		 1cbsA-4fdjA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 THR A 348
SER A 349
PHE A 227
ALA A  75
ALA A  85
 None
 1.06A 1q23A-4fdjA:
undetectable
1q23B-4fdjA:
undetectable		 1q23A-4fdjA:
15.49
1q23B-4fdjA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 PHE A  72
LEU A  86
ARG A  83
GLY A 365
LEU A 368
 None
None
DDZ  A  79 ( 4.2A)
None
None
 1.30A 2lbdA-4fdjA:
undetectable		 2lbdA-4fdjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 LEU A 390
THR A 389
ALA A 393
THR A 394
ILE A 382
 None
 1.15A 3a35B-4fdjA:
undetectable		 3a35B-4fdjA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		3 / 3 ASN A 289
ASP A  39
ARG A 175
 CA  A 603 (-2.9A)
CA  A 603 (-3.5A)
None
 0.89A 3k13A-4fdjA:
undetectable		 3k13A-4fdjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 TYR A 254
GLY A 201
ALA A 241
THR A 206
ILE A 261
 None
 1.29A 3ld6A-4fdjA:
undetectable		 3ld6A-4fdjA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 TYR A 254
GLY A 201
ALA A 241
THR A 206
ILE A 261
 None
 1.20A 3ld6B-4fdjA:
undetectable		 3ld6B-4fdjA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		3 / 3 PRO A 321
SER A 287
ASN A 303
 None
 0.92A 3lslG-4fdjA:
undetectable		 3lslG-4fdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 GLY A 316
GLY A 317
PRO A  70
VAL A 335
LEU A  68
 None
 0.91A 3m6wA-4fdjA:
undetectable		 3m6wA-4fdjA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 9 ALA A 203
TYR A 170
ASN A 177
ILE A 178
GLU A 192
 None
 1.26A 3rukC-4fdjA:
undetectable		 3rukC-4fdjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 11 PHE A 284
PHE A 282
PHE A  72
LEU A 372
PHE A  69
 None
 1.02A 3t3rA-4fdjA:
undetectable		 3t3rA-4fdjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 VAL A 277
PHE A 216
ILE A 217
PHE A 226
HIS A 224
 None
 1.41A 4c49D-4fdjA:
undetectable		 4c49D-4fdjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		4 / 5 GLY A  89
LEU A  37
LEU A 143
LEU A 128
 None
 0.81A 4o8fA-4fdjA:
undetectable		 4o8fA-4fdjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		3 / 3 GLN A 397
HIS A 443
ARG A 446
 None
 1.24A 4qyqA-4fdjA:
undetectable		 4qyqA-4fdjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		3 / 3 GLN A 397
HIS A 443
ARG A 446
 None
 1.25A 4qyqB-4fdjA:
undetectable		 4qyqB-4fdjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 ASN A 303
PRO A  77
ASP A  40
ASN A 289
HIS A 236
 None
None
CA  A 603 (-3.0A)
CA  A 603 (-2.9A)
NGA  A 604 (-3.3A)
 1.42A 5dv4A-4fdjA:
undetectable		 5dv4A-4fdjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 ILE A 137
PRO A 125
LEU A  87
GLU A 158
PHE A 156
 None
 1.34A 5k7uA-4fdjA:
undetectable		 5k7uA-4fdjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 SER A 287
ALA A 292
TYR A 254
ALA A 291
GLY A 290
 None
 1.39A 5tzoA-4fdjA:
undetectable		 5tzoA-4fdjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		5 / 12 SER A 287
ALA A 292
TYR A 254
ALA A 291
GLY A 290
 None
 1.36A 5tzoC-4fdjA:
undetectable		 5tzoC-4fdjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		4 / 8 ILE A 265
MET A  41
LEU A  37
ILE A 261
 None
 0.90A 5uihA-4fdjA:
undetectable		 5uihA-4fdjA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens) 		4 / 6 TRP A 141
LEU A 128
GLN A 148
GLU A 126
 None
 1.41A 6djzC-4fdjA:
undetectable		 6djzC-4fdjA:
21.80