SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 283
VAL A 341
TRP A 353
 None
 0.58A 1bdwA-4fduA:
undetectable
1bdwB-4fduA:
undetectable		 1bdwA-4fduA:
3.16
1bdwB-4fduA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 321
SER A 173
ALA A 144
ILE A 143
 None
 1.12A 1pnlA-4fduA:
undetectable
1pnlB-4fduA:
undetectable		 1pnlA-4fduA:
18.56
1pnlB-4fduA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 196
ASP A 186
PHE A 185
ARG A 183
 None
None
IHS  A 501 ( 4.9A)
IHS  A 501 (-3.1A)
 1.39A 2a3bB-4fduA:
undetectable		 2a3bB-4fduA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		3 / 3 PRO A 290
GLY A 286
TYR A 194
 None
 0.67A 2vouA-4fduA:
undetectable		 2vouA-4fduA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		3 / 3 PRO A 290
GLY A 286
TYR A 194
 None
 0.71A 2vouB-4fduA:
undetectable		 2vouB-4fduA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 330
ALA A 324
VAL A 365
LEU A 297
PHE A 301
 None
IHS  A 501 (-3.4A)
None
None
None
 1.06A 3ay0A-4fduA:
undetectable		 3ay0A-4fduA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		5 / 10 SER A 112
LEU A  70
LEU A 100
SER A 251
LEU A 256
 None
 1.10A 4yiaA-4fduA:
undetectable		 4yiaA-4fduA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 408
ILE A 392
GLY A 335
THR A 339
 None
 0.91A 4ze3A-4fduA:
undetectable		 4ze3A-4fduA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 408
ILE A 392
GLY A 335
THR A 339
 None
 0.89A 5esjA-4fduA:
0.0		 5esjA-4fduA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 408
ILE A 392
GLY A 335
THR A 339
 None
 0.95A 5esmA-4fduA:
0.5		 5esmA-4fduA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A  63
LEU A 114
ARG A 149
GLY A  60
 None
None
IHS  A 501 (-3.5A)
None
 1.11A 5o4yA-4fduA:
undetectable		 5o4yA-4fduA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A  63
LEU A 114
ARG A 149
GLY A  60
 None
None
IHS  A 501 (-3.5A)
None
 1.05A 5o4yF-4fduA:
undetectable		 5o4yF-4fduA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4fdu PUTATIVE MULTIPLE
INOSITOL
POLYPHOSPHATE
HISTIDINE
PHOSPHATASE 1
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 252
ILE A 246
PHE A  63
SER A 112
LEU A 256
 None
 1.30A 5tiwB-4fduA:
undetectable		 5tiwB-4fduA:
20.05