SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 SER A 239
PHE A 244
GLY A 237
TRP A 252
 None
 0.95A 1fapB-4fdyA:
undetectable		 1fapB-4fdyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 314
ALA A 313
ILE A 250
ILE A 303
ALA A 265
 None
OCS  A 246 ( 3.5A)
OCS  A 246 ( 4.2A)
None
OCS  A 246 ( 4.0A)
 0.84A 1sguB-4fdyA:
undetectable		 1sguB-4fdyA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 7 VAL A 198
ASP A 131
TYR A 197
ILE A  79
 None
 1.01A 3avpA-4fdyA:
undetectable		 3avpA-4fdyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 ILE A 221
LEU A 285
VAL A 337
GLY A 283
 None
 0.81A 3dcjB-4fdyA:
undetectable		 3dcjB-4fdyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 9 ALA A  78
LEU A 205
ILE A 132
LEU A 122
TYR A 197
 None
 1.19A 3fl9D-4fdyA:
undetectable		 3fl9D-4fdyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 10 PHE A 287
VAL A 298
GLN A 266
ILE A 275
GLY A 333
 None
 1.27A 3km6A-4fdyA:
undetectable		 3km6A-4fdyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 237
GLY A 236
ASP A 255
VAL A 337
LEU A 285
 None
 1.06A 3m6wA-4fdyA:
undetectable		 3m6wA-4fdyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 6 PHE A 213
ILE A 259
ALA A 257
ALA A 225
 None
 1.06A 3mdrB-4fdyA:
undetectable		 3mdrB-4fdyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 142
TYR A 148
SER A 138
TYR A 141
 None
 0.74A 3u9hA-4fdyA:
undetectable		 3u9hA-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 142
TYR A 148
SER A 138
TYR A 141
 None
 0.78A 3u9hB-4fdyA:
undetectable		 3u9hB-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A 218
ILE A 221
TYR A 254
ILE A 250
 None
None
None
OCS  A 246 ( 4.2A)
 0.84A 3uqbA-4fdyA:
undetectable		 3uqbA-4fdyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 7 TYR A 233
ASP A 245
SER A 247
HIS A 300
 None
OCS  A 246 ( 4.2A)
OCS  A 246 ( 3.5A)
OCS  A 246 ( 3.8A)
 1.36A 4arcA-4fdyA:
undetectable		 4arcA-4fdyA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 142
TYR A 148
SER A 138
TYR A 141
 None
 0.71A 4bjcA-4fdyA:
undetectable		 4bjcA-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 11 LEU A 200
ASN A 194
TYR A 156
ALA A 161
PHE A 196
 None
 1.44A 4evrA-4fdyA:
undetectable		 4evrA-4fdyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 7 GLY A 193
TYR A 190
ALA A 161
GLU A 162
 None
 0.93A 4hyfA-4fdyA:
undetectable		 4hyfA-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 193
TYR A 190
ALA A 161
GLU A 162
 None
 0.92A 4hyfB-4fdyA:
undetectable		 4hyfB-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 142
TYR A 148
SER A 138
TYR A 141
 None
 0.91A 4hyfC-4fdyA:
undetectable		 4hyfC-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 GLY A 193
TYR A 190
ALA A 161
GLU A 162
 None
 0.92A 4hyfC-4fdyA:
undetectable		 4hyfC-4fdyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 8 SER A 247
GLN A 268
VAL A 298
THR A 296
 OCS  A 246 ( 3.5A)
None
None
None
 1.12A 4lnwA-4fdyA:
undetectable		 4lnwA-4fdyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 6 SER A 247
GLN A 268
VAL A 298
THR A 296
 OCS  A 246 ( 3.5A)
None
None
None
 1.25A 4lnxA-4fdyA:
undetectable		 4lnxA-4fdyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		5 / 12 ILE A 221
ASP A 245
ARG A 263
LEU A 285
ILE A 303
 None
OCS  A 246 ( 4.2A)
None
None
None
 1.08A 4m2xE-4fdyA:
undetectable		 4m2xE-4fdyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 5 TYR A 197
TYR A 176
GLU A  83
ASP A  90
 None
 1.28A 4x61A-4fdyA:
undetectable		 4x61A-4fdyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY
(Staphylococcus
aureus) 		4 / 6 TYR A 197
TYR A 176
GLU A  83
ASP A  90
 None
 1.29A 5emlA-4fdyA:
undetectable		 5emlA-4fdyA:
19.21