SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fe1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4fe1	PHOTOSYSTEM I REACTION CENTER SUBUNIT XI (Thermosynechococ cus elongatus)	5 / 12	LEU L 41 SER L 42 PRO L 43 GLN L 119 GLY L 40	None	0.93A	1uakA-4fe1L: undetectable	1uakA-4fe1L: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_B_VDYB6178_1 (VITAMIN D HYDROXYLASE)	4fe1	PHOTOSYSTEM I IRON-SULFUR CENTER (Thermosynechococ cus elongatus)	5 / 12	PRO C 58 THR C 59 ILE C 6 VAL C 24 LEU C 25	SF4 C 102 ( 4.9A) SF4 C 102 ( 4.4A) None SF4 C 101 (-4.3A) SF4 C 101 ( 4.9A)	1.23A	3a51B-4fe1C: undetectable	3a51B-4fe1C: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4fe1	PHOTOSYSTEM I REACTION CENTER SUBUNIT XI (Thermosynechococ cus elongatus)	5 / 12	PHE L 124 GLY L 51 ALA L 84 GLY L 55 LEU L 58	BCR L1005 (-4.3A) None None None None	0.99A	3hs6B-4fe1L: 0.7	3hs6B-4fe1L: 13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I1R_A_LZUA801_1 (MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1)	4fe1	PHOTOSYSTEM I REACTION CENTER SUBUNIT XI (Thermosynechococ cus elongatus)	5 / 12	LEU L 79 ALA L 132 PHE L 136 LEU L 138 LEU L 139	None None None CLA L1004 ( 4.6A) CLA L1004 (-4.3A)	0.97A	4i1rA-4fe1L: undetectable	4i1rA-4fe1L: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AJI_A_AY6A1001_0 (DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN)	4fe1	PHOTOSYSTEM I REACTION CENTER SUBUNIT XI (Thermosynechococ cus elongatus)	5 / 12	LEU L 85 ILE L 83 ILE L 59 VAL L 88 ALA L 89	None None None None BCR L1005 ( 3.5A)	0.96A	6ajiA-4fe1L: undetectable	6ajiA-4fe1L: 10.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4fe1","PHOTOSYSTEM I REACTION CENTER SUBUNIT XI","Thermosynechococcus elongatus",5,"LEU L  41;SER L  42;PRO L  43;GLN L 119;GLY L  40","None","0.93A","1uakA-4fe1L:undetectable","1uakA-4fe1L:19.17"],["3A51_B_VDYB6178_1","VITAMIN D HYDROXYLASE","4fe1","PHOTOSYSTEM I IRON-SULFUR CENTER","Thermosynechococcus elongatus",5,"PRO C  58;THR C  59;ILE C   6;VAL C  24;LEU C  25","SF4 C 102 ( 4.9A);SF4 C 102 ( 4.4A);None;SF4 C 101 (-4.3A);SF4 C 101 ( 4.9A)","1.23A","3a51B-4fe1C:undetectable","3a51B-4fe1C:13.65"],["3HS6_B_EPAB1_1","PROSTAGLANDIN G\/H SYNTHASE 2","4fe1","PHOTOSYSTEM I REACTION CENTER SUBUNIT XI","Thermosynechococcus elongatus",5,"PHE L 124;GLY L  51;ALA L  84;GLY L  55;LEU L  58","BCR L1005 (-4.3A);None;None;None;None","0.99A","3hs6B-4fe1L:0.7","3hs6B-4fe1L:13.85"],["4I1R_A_LZUA801_1","MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1","4fe1","PHOTOSYSTEM I REACTION CENTER SUBUNIT XI","Thermosynechococcus elongatus",5,"LEU L  79;ALA L 132;PHE L 136;LEU L 138;LEU L 139","None;None;None;CLA L1004 ( 4.6A);CLA L1004 (-4.3A)","0.97A","4i1rA-4fe1L:undetectable","4i1rA-4fe1L:18.97"],["6AJI_A_AY6A1001_0","DRUG EXPORTERS OF THE RND SUPERFAMILY-LIKE PROTEIN,ENDOLYSIN","4fe1","PHOTOSYSTEM I REACTION CENTER SUBUNIT XI","Thermosynechococcus elongatus",5,"LEU L  85;ILE L  83;ILE L  59;VAL L  88;ALA L  89","None;None;None;None;BCR L1005 ( 3.5A)","0.96A","6ajiA-4fe1L:undetectable","6ajiA-4fe1L:10.81"]]