SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fe2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 192
LEU A 220
TYR A 224
GLY A  46
ALA A  11
 None
None
None
None
ADP  A 302 (-3.4A)
 1.16A 1httC-4fe2A:
undetectable		 1httC-4fe2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 192
LEU A 220
TYR A 224
GLY A  46
ALA A  11
 None
None
None
None
ADP  A 302 (-3.4A)
 1.20A 1httD-4fe2A:
undetectable		 1httD-4fe2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.48A 1kiaB-4fe2A:
undetectable		 1kiaB-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.47A 1kiaC-4fe2A:
undetectable		 1kiaC-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.48A 1nbhB-4fe2A:
0.0		 1nbhB-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 214
ASP A 128
ASP A 125
 AIR  A 301 (-3.1A)
ASP  A 306 ( 4.0A)
None
 0.79A 2ejtA-4fe2A:
undetectable		 2ejtA-4fe2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 177
LEU A  92
PHE A 193
LEU A 161
ILE A 157
 None
 1.23A 2f78A-4fe2A:
undetectable		 2f78A-4fe2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 177
LEU A  92
PHE A 193
LEU A 161
ILE A 157
 None
 1.25A 2f78B-4fe2A:
undetectable		 2f78B-4fe2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 177
LEU A  92
PHE A 193
LEU A 161
ILE A 157
 None
 1.17A 2f7aB-4fe2A:
undetectable		 2f7aB-4fe2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 174
ILE A 173
TRP A 201
ASP A 211
ARG A 215
 AIR  A 301 (-2.9A)
None
None
None
None
 1.42A 2qmjA-4fe2A:
undetectable		 2qmjA-4fe2A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 177
ASN A 158
LEU A 161
ARG A 155
 None
 1.08A 2xn3A-4fe2A:
undetectable
2xn3B-4fe2A:
undetectable		 2xn3A-4fe2A:
22.67
2xn3B-4fe2A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ASP A 209
ASP A 211
GLU A 108
HIS A 207
ILE A 173
 None
 1.11A 3o94A-4fe2A:
undetectable		 3o94A-4fe2A:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ASP A 209
ASP A 211
GLU A 108
HIS A 207
ILE A 173
 None
 1.11A 3o94C-4fe2A:
undetectable		 3o94C-4fe2A:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ASP A 209
ASP A 211
GLU A 108
HIS A 207
ILE A 173
 None
 1.11A 3o94D-4fe2A:
undetectable		 3o94D-4fe2A:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 174
ILE A 173
TRP A 201
ASP A 211
ARG A 215
 AIR  A 301 (-2.9A)
None
None
None
None
 1.46A 3phaC-4fe2A:
undetectable		 3phaC-4fe2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 174
ILE A 173
TRP A 201
ASP A 211
ARG A 215
 AIR  A 301 (-2.9A)
None
None
None
None
 1.45A 3phaD-4fe2A:
undetectable		 3phaD-4fe2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.81A 4fp9A-4fe2A:
undetectable		 4fp9A-4fe2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.86A 4fp9C-4fe2A:
undetectable		 4fp9C-4fe2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 209
ARG A 199
ASP A 202
 None
AIR  A 301 (-3.1A)
None
 0.82A 4fp9F-4fe2A:
undetectable		 4fp9F-4fe2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 ASN A  94
ARG A  93
ASN A 158
ILE A 157
 144  A 308 (-4.8A)
AIR  A 301 (-2.9A)
None
None
 1.02A 4k0bA-4fe2A:
undetectable		 4k0bA-4fe2A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 VAL A  65
GLY A  64
THR A  67
LEU A 189
SER A  53
 144  A 307 ( 4.3A)
144  A 304 ( 3.6A)
None
None
None
 1.48A 4or0A-4fe2A:
undetectable		 4or0A-4fe2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A  31
THR A  32
ALA A  33
LYS A  45
 None
 0.95A 4qw0K-4fe2A:
undetectable		 4qw0K-4fe2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A  31
THR A  32
ALA A  33
LYS A  45
 None
 0.96A 4qw0Y-4fe2A:
undetectable		 4qw0Y-4fe2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 GLU A 192
LYS A  12
ASP A 191
GLU A 178
 None
ADP  A 302 (-2.8A)
ADP  A 302 ( 3.9A)
ADP  A 302 (-3.5A)
 1.42A 5a06A-4fe2A:
undetectable		 5a06A-4fe2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 ARG A 215
ARG A  93
ASP A 174
ILE A 173
 None
AIR  A 301 (-2.9A)
AIR  A 301 (-2.9A)
None
 1.07A 5a06B-4fe2A:
undetectable		 5a06B-4fe2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 192
LEU A 220
TYR A 224
GLY A  46
ALA A  11
 None
None
None
None
ADP  A 302 (-3.4A)
 1.18A 5e3iA-4fe2A:
undetectable		 5e3iA-4fe2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 155
PRO A 115
ASN A  94
 None
144  A 308 ( 4.9A)
144  A 308 (-4.8A)
 1.02A 5jwaA-4fe2A:
undetectable
5jwaH-4fe2A:
undetectable		 5jwaA-4fe2A:
21.67
5jwaH-4fe2A:
21.67