SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fe4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 243
GLY A  25
GLU A  24
ASP A  63
VAL A  83
 None
 1.10A 2wa2A-4fe4A:
undetectable		 2wa2A-4fe4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 10 ASP A 219
ASN A 220
TYR A 125
ILE A 218
GLY A 217
 None
 1.40A 3myuB-4fe4A:
0.0		 3myuB-4fe4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 219
TRP A 135
ASP A  63
ASP A  65
 None
 1.15A 3n2oC-4fe4A:
undetectable
3n2oD-4fe4A:
3.1		 3n2oC-4fe4A:
19.40
3n2oD-4fe4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 123
ILE A 216
PHE A 111
VAL A 119
 None
 0.95A 4ax8A-4fe4A:
3.5		 4ax8A-4fe4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 123
ILE A 216
PHE A 111
VAL A 119
 None
 0.97A 4azvA-4fe4A:
undetectable		 4azvA-4fe4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 SER A 352
ILE A 353
PHE A 368
GLU A 355
 None
 1.27A 4cx7A-4fe4A:
undetectable
4cx7B-4fe4A:
undetectable		 4cx7A-4fe4A:
22.51
4cx7B-4fe4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 6 ASP A  63
ASP A  65
ASN A 103
ARG A 139
 None
 1.24A 4ntxA-4fe4A:
undetectable
4ntxC-4fe4A:
0.4		 4ntxA-4fe4A:
19.96
4ntxC-4fe4A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 188
PHE A 124
VAL A 107
GLU A 140
 None
 1.00A 5dqyA-4fe4A:
2.3		 5dqyA-4fe4A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 386
ASP A 385
GLU A 382
LEU A 339
PRO A 380
 None
 1.34A 5hnxB-4fe4A:
3.2		 5hnxB-4fe4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 365
TYR A 369
THR A 379
THR A 378
 None
 0.92A 5jq7B-4fe4A:
undetectable		 5jq7B-4fe4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4fe4 XYLOSE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 243
GLY A  25
GLU A  24
ASP A  63
VAL A  83
 None
 1.03A 5njvD-4fe4A:
undetectable		 5njvD-4fe4A:
22.31