SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fe9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 367
GLY A 312
LEU A 300
VAL A 322
PHE A 380
 None
EDO  A 511 (-3.4A)
None
None
None
 1.41A 1a27A-4fe9A:
undetectable		 1a27A-4fe9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 233
VAL A 230
SER A 229
ASP A 237
 None
 1.32A 1n2xB-4fe9A:
undetectable		 1n2xB-4fe9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 0.94A 2avoA-4fe9A:
undetectable		 2avoA-4fe9A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 446
LEU A 475
ILE A 484
VAL A 427
VAL A 385
 None
 1.11A 2g78A-4fe9A:
undetectable		 2g78A-4fe9A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 0.98A 3em3B-4fe9A:
undetectable		 3em3B-4fe9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 395
ASP A 404
VAL A 465
GLY A 425
PHE A 421
 NA  A 514 (-4.3A)
NA  A 514 (-2.8A)
None
None
None
 1.02A 3keeB-4fe9A:
undetectable		 3keeB-4fe9A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 395
ASP A 404
VAL A 465
GLY A 425
PHE A 421
 NA  A 514 (-4.3A)
NA  A 514 (-2.8A)
None
None
None
 1.01A 3keeC-4fe9A:
undetectable		 3keeC-4fe9A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 9 GLY A 389
ILE A 484
PHE A 416
PHE A 477
PHE A 446
 None
None
None
EDO  A 511 ( 4.9A)
None
 1.49A 3ko0A-4fe9A:
undetectable
3ko0C-4fe9A:
undetectable		 3ko0A-4fe9A:
11.54
3ko0C-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 389
PHE A 416
PHE A 477
PHE A 446
 None
None
EDO  A 511 ( 4.9A)
None
 1.04A 3ko0D-4fe9A:
undetectable
3ko0E-4fe9A:
undetectable		 3ko0D-4fe9A:
11.54
3ko0E-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 324
GLY A 335
PHE A 334
PHE A 310
 None
 0.96A 3ko0D-4fe9A:
undetectable
3ko0E-4fe9A:
undetectable		 3ko0D-4fe9A:
11.54
3ko0E-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A 446
GLY A 389
ILE A 484
PHE A 416
PHE A 477
 None
None
None
None
EDO  A 511 ( 4.9A)
 1.49A 3ko0F-4fe9A:
undetectable
3ko0G-4fe9A:
undetectable		 3ko0F-4fe9A:
11.54
3ko0G-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 446
GLY A 389
PHE A 416
PHE A 477
 None
None
None
EDO  A 511 ( 4.9A)
 1.02A 3ko0B-4fe9A:
undetectable
3ko0J-4fe9A:
undetectable		 3ko0B-4fe9A:
11.54
3ko0J-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 389
PHE A 416
PHE A 477
PHE A 446
 None
None
EDO  A 511 ( 4.9A)
None
 1.08A 3ko0L-4fe9A:
undetectable
3ko0N-4fe9A:
undetectable		 3ko0L-4fe9A:
11.54
3ko0N-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 310
PHE A 324
GLY A 335
PHE A 334
 None
 0.91A 3ko0M-4fe9A:
undetectable
3ko0P-4fe9A:
undetectable		 3ko0M-4fe9A:
11.54
3ko0P-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 310
PHE A 324
GLY A 335
PHE A 334
 None
 0.94A 3ko0O-4fe9A:
undetectable
3ko0Q-4fe9A:
undetectable		 3ko0O-4fe9A:
11.54
3ko0Q-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 324
GLY A 335
PHE A 334
PHE A 310
 None
 0.95A 3ko0O-4fe9A:
undetectable
3ko0Q-4fe9A:
undetectable		 3ko0O-4fe9A:
11.54
3ko0Q-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 10 GLY A 389
ILE A 484
PHE A 416
PHE A 477
PHE A 446
 None
None
None
EDO  A 511 ( 4.9A)
None
 1.50A 3ko0R-4fe9A:
undetectable
3ko0T-4fe9A:
undetectable		 3ko0R-4fe9A:
11.54
3ko0T-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 446
GLY A 389
PHE A 416
PHE A 477
 None
None
None
EDO  A 511 ( 4.9A)
 1.03A 3ko0K-4fe9A:
undetectable
3ko0S-4fe9A:
undetectable		 3ko0K-4fe9A:
11.54
3ko0S-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 446
GLY A 389
PHE A 416
PHE A 477
 None
None
None
EDO  A 511 ( 4.9A)
 1.02A 3ko0R-4fe9A:
undetectable
3ko0T-4fe9A:
undetectable		 3ko0R-4fe9A:
11.54
3ko0T-4fe9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 1.14A 3oxxB-4fe9A:
undetectable		 3oxxB-4fe9A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 0.92A 4dqbA-4fe9A:
undetectable		 4dqbA-4fe9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 174
ASP A 173
THR A 250
ILE A 248
 None
GLC  A 502 ( 2.6A)
None
None
 1.02A 4pcuA-4fe9A:
undetectable		 4pcuA-4fe9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 0.92A 4q1xB-4fe9A:
undetectable		 4q1xB-4fe9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 480
PHE A 449
GLY A 451
ASP A 450
TYR A 455
 None
 1.19A 4rtsA-4fe9A:
undetectable		 4rtsA-4fe9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 264
ALA A 122
ARG A 126
 None
 0.62A 5cvtB-4fe9A:
undetectable		 5cvtB-4fe9A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 266
ASP A 233
GLY A 236
ASP A 237
 None
 1.15A 5hp1A-4fe9A:
undetectable		 5hp1A-4fe9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jsdA-4fe9A:
undetectable		 5jsdA-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jsdB-4fe9A:
undetectable		 5jsdB-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jsdC-4fe9A:
undetectable		 5jsdC-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jseA-4fe9A:
undetectable		 5jseA-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jseB-4fe9A:
2.4		 5jseB-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 309
SER A 370
TYR A 368
 None
 0.83A 5jseC-4fe9A:
undetectable		 5jseC-4fe9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 387
ILE A 453
GLY A 482
VAL A 427
ILE A 429
 None
 1.15A 5kr2D-4fe9A:
undetectable		 5kr2D-4fe9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 484
PHE A 421
GLY A 425
ILE A 429
LEU A 387
 None
 0.98A 6dwnC-4fe9A:
undetectable		 6dwnC-4fe9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 344
SER A 341
ALA A 435
 None
 0.67A 6dwnC-4fe9A:
undetectable		 6dwnC-4fe9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4fe9 OUTER MEMBRANE
PROTEIN SUSF
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 484
PHE A 421
GLY A 425
ILE A 429
LEU A 387
 None
 0.99A 6dwnD-4fe9A:
undetectable		 6dwnD-4fe9A:
10.49