SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 9 TYR A  35
HIS A 179
ARG A  92
HIS A 231
THR A  41
 None
None
PO4  A 303 (-4.0A)
None
None
 1.31A 1nkiA-4fekA:
undetectable
1nkiB-4fekA:
undetectable		 1nkiA-4fekA:
20.15
1nkiB-4fekA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 9 HIS A 231
THR A  41
TYR A  35
HIS A 179
ARG A  92
 None
None
None
None
PO4  A 303 (-4.0A)
 1.31A 1nkiA-4fekA:
undetectable
1nkiB-4fekA:
undetectable		 1nkiA-4fekA:
20.15
1nkiB-4fekA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 138
ILE A  84
ILE A  48
ASP A  81
 None
 0.87A 1uwjA-4fekA:
undetectable		 1uwjA-4fekA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		3 / 3 GLN A 168
ILE A 169
TYR A 163
 None
 0.75A 1vifA-4fekA:
undetectable		 1vifA-4fekA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 236
LEU A 226
THR A  18
 None
 0.90A 3oxcA-4fekA:
undetectable		 3oxcA-4fekA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  54
ASP A  81
VAL A 109
VAL A 145
ILE A  84
 None
 1.05A 3oxxA-4fekA:
undetectable		 3oxxA-4fekA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 11 ARG A  92
PHE A  63
ASN A  91
SER A  25
GLY A 230
 PO4  A 303 (-4.0A)
None
PO4  A 303 (-2.9A)
None
None
 1.44A 4a99B-4fekA:
undetectable		 4a99B-4fekA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 11 ARG A  92
PHE A  63
ASN A  91
SER A  25
GLY A 230
 PO4  A 303 (-4.0A)
None
PO4  A 303 (-2.9A)
None
None
 1.45A 4a99C-4fekA:
undetectable		 4a99C-4fekA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 8 SER A  43
ASN A  44
ARG A  22
GLY A  40
 None
 0.99A 4af0A-4fekA:
undetectable		 4af0A-4fekA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A 169
THR A 167
LEU A 140
GLY A  50
ILE A  56
 None
 0.99A 4c9lA-4fekA:
undetectable		 4c9lA-4fekA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A 169
THR A 167
LEU A 140
GLY A  50
ILE A  56
 None
 0.97A 4c9lB-4fekA:
undetectable		 4c9lB-4fekA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 5 GLN A  10
THR A  18
LEU A 226
LEU A 234
 None
 1.10A 4lvcB-4fekA:
undetectable		 4lvcB-4fekA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A  21
SER A  45
ILE A  55
VAL A  83
 None
 1.11A 4tvtA-4fekA:
undetectable		 4tvtA-4fekA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 6 ALA A 245
GLN A 244
LEU A 242
LEU A 216
 None
 1.14A 4xoyA-4fekA:
undetectable		 4xoyA-4fekA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A  99
PRO A  58
LEU A  68
TYR A  67
 None
 0.88A 4z4fA-4fekA:
undetectable		 4z4fA-4fekA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 5 SER A  43
ALA A  23
HIS A 231
LEU A  29
 None
 1.48A 5dzkb-4fekA:
undetectable
5dzkp-4fekA:
undetectable		 5dzkb-4fekA:
23.19
5dzkp-4fekA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 5 SER A  43
ALA A  23
HIS A 231
LEU A  29
 None
 1.48A 5dzkc-4fekA:
undetectable
5dzkq-4fekA:
undetectable		 5dzkc-4fekA:
23.19
5dzkq-4fekA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A  99
PRO A  58
LEU A  68
TYR A  67
 None
 0.86A 5t7bA-4fekA:
undetectable		 5t7bA-4fekA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5
(Nostoc
sp.
PCC
7120) 		5 / 10 HIS A 231
THR A  41
TYR A  35
HIS A 179
ARG A  92
 None
None
None
None
PO4  A 303 (-4.0A)
 1.29A 5v3dA-4fekA:
undetectable
5v3dB-4fekA:
undetectable		 5v3dA-4fekA:
18.70
5v3dB-4fekA:
18.70