SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 12 MET A 181
PHE A 208
ILE A 183
PHE A 263
ILE A 278
 None
 1.31A 1ot7A-4femA:
undetectable		 1ot7A-4femA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.32A 2a3cA-4femA:
undetectable		 2a3cA-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 192
GLY A 249
PHE A 253
SER A 248
 ACX  A 401 (-3.9A)
None
None
None
 1.34A 2a3cB-4femA:
undetectable		 2a3cB-4femA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 352
ARG A 326
ILE A 375
ARG A 350
GLU A 339
 None
 1.04A 2j0dA-4femA:
undetectable		 2j0dA-4femA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 326
GLU A 339
TYR A 202
TRP A 336
 None
 1.38A 2q6uA-4femA:
undetectable		 2q6uA-4femA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 7 ILE A 232
GLY A 231
PHE A 222
PHE A 263
ILE A 278
 None
 1.36A 2y7wC-4femA:
undetectable		 2y7wC-4femA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 278
GLN A 207
ILE A 183
LEU A 333
 None
 1.17A 3dzyD-4femA:
undetectable		 3dzyD-4femA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 0.95A 3ko0B-4femA:
undetectable
3ko0J-4femA:
undetectable		 3ko0B-4femA:
15.73
3ko0J-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 289
PHE A 314
PHE A 379
PHE A 340
 None
 0.94A 3ko0D-4femA:
undetectable
3ko0E-4femA:
undetectable		 3ko0D-4femA:
15.73
3ko0E-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.93A 3ko0B-4femA:
undetectable
3ko0J-4femA:
undetectable		 3ko0B-4femA:
15.73
3ko0J-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.94A 3ko0K-4femA:
undetectable
3ko0S-4femA:
undetectable		 3ko0K-4femA:
15.73
3ko0S-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 340
GLY A 289
PHE A 314
PHE A 379
 None
 0.96A 3ko0R-4femA:
undetectable
3ko0T-4femA:
undetectable		 3ko0R-4femA:
15.73
3ko0T-4femA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 237
GLU A 256
LYS A 221
PHE A 222
 None
None
ACX  A 401 (-2.9A)
None
 1.46A 3rv5C-4femA:
undetectable
3rv5D-4femA:
undetectable		 3rv5C-4femA:
16.56
3rv5D-4femA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.44A 3t3qA-4femA:
undetectable		 3t3qA-4femA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.45A 3t3qB-4femA:
undetectable		 3t3qB-4femA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.44A 3t3qC-4femA:
undetectable		 3t3qC-4femA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 PHE A 263
PHE A 280
VAL A 239
ILE A 230
PHE A 222
 None
 1.41A 3t3qD-4femA:
undetectable		 3t3qD-4femA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 241
ALA A 245
GLY A 246
VAL A 239
VAL A 254
 None
 1.31A 4c5nD-4femA:
undetectable		 4c5nD-4femA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		5 / 7 PHE A 222
ASN A 252
GLY A 231
ILE A 278
PHE A 263
 None
ACX  A 401 (-3.1A)
None
None
None
 1.39A 4ejjA-4femA:
undetectable		 4ejjA-4femA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 352
ARG A 350
ILE A 355
GLU A 360
 None
 1.36A 4zzcB-4femA:
undetectable
4zzcC-4femA:
undetectable		 4zzcB-4femA:
21.25
4zzcC-4femA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 352
ARG A 350
ILE A 355
GLU A 360
 None
 1.33A 4zzcC-4femA:
0.4
4zzcD-4femA:
0.4		 4zzcC-4femA:
21.25
4zzcD-4femA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 352
ARG A 350
ILE A 355
GLU A 360
 None
 1.37A 4zzcD-4femA:
0.4
4zzcE-4femA:
0.4		 4zzcD-4femA:
21.25
4zzcE-4femA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 355
GLU A 360
PHE A 352
ARG A 350
 None
 1.30A 4zzcA-4femA:
0.0
4zzcE-4femA:
0.4		 4zzcA-4femA:
21.25
4zzcE-4femA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fem OUTER MEMBRANE
PROTEIN SUSE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 347
GLY A 382
PHE A 214
PHE A 263
 None
 1.14A 5hieA-4femA:
undetectable		 5hieA-4femA:
22.10