SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4feq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 VAL A 576
GLY A 575
LEU A 573
PHE A 555
GLU A 558
None
1.19A 1a27A-4feqA:
undetectable
1a27A-4feqA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 MET A 633
LEU A 636
SER A 637
None
0.62A 1ee2A-4feqA:
undetectable
1ee2A-4feqA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.66A 1iepB-4feqA:
22.8
1iepB-4feqA:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 LEU A 780
LEU A 776
LEU A 754
MET A 716
MET A 748
None
1.49A 1sqnA-4feqA:
undetectable
1sqnA-4feqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
1.35A 2eimJ-4feqA:
undetectable
2eimJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
1.38A 2eimW-4feqA:
undetectable
2eimW-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
VAL A 522
ALA A 538
ASP A 645
ASN A 650
MET A 652
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
None
0T8  A 901 (-3.9A)
0.97A 2fumA-4feqA:
16.3
2fumA-4feqA:
26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 LEU A 606
LEU A 653
MET A 652
None
None
0T8  A 901 (-3.9A)
0.75A 2itzA-4feqA:
25.4
2itzA-4feqA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 GLY A 515
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
MET A 652
ALA A 662
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
0.81A 2wgjA-4feqA:
29.6
2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 GLY A 515
VAL A 522
ALA A 538
MET A 596
GLY A 599
MET A 652
ALA A 662
ASP A 663
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.92A 2wgjA-4feqA:
29.6
2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.88A 2xp2A-4feqA:
28.1
2xp2A-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
GLU A 524
ALA A 538
LYS A 540
PHE A 595
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
None
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0.70A 3c7qA-4feqA:
24.7
3c7qA-4feqA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 ALA A 538
PHE A 595
PHE A 641
HIS A 643
ALA A 662
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
0.64A 3cs9C-4feqA:
23.6
3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 PHE A 595
PHE A 641
HIS A 643
ALA A 662
ASP A 663
0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.81A 3cs9C-4feqA:
23.6
3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 ALA A 538
PHE A 595
GLY A 599
PHE A 641
HIS A 643
ALA A 662
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0T8  A 901 ( 4.5A)
0.60A 3cs9D-4feqA:
23.1
3cs9D-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 9 ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0.72A 3miyB-4feqA:
24.8
3miyB-4feqA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.60A 3ms9B-4feqA:
22.7
3ms9B-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.67A 3mssB-4feqA:
23.0
3mssB-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.83A 3mssD-4feqA:
23.0
3mssD-4feqA:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 GLN A 506
GLU A 505
LYS A 505
None
1.12A 3su9A-4feqA:
undetectable
3su9A-4feqA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0.74A 3wzeA-4feqA:
22.5
3wzeA-4feqA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
ALA A 538
MET A 596
GLY A 599
ASP A 600
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
0.93A 3zbfA-4feqA:
29.3
3zbfA-4feqA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.89A 4anqA-4feqA:
16.8
4anqA-4feqA:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.86A 4ansA-4feqA:
22.2
4ansA-4feqA:
35.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0.75A 4asdA-4feqA:
22.4
4asdA-4feqA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ASP A 600
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
0.85A 4mkcA-4feqA:
11.0
4mkcA-4feqA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
1.01A 4mkcA-4feqA:
11.0
4mkcA-4feqA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 6 ASN A 640
TYR A 635
LEU A 636
PHE A 565
None
1.14A 4twdI-4feqA:
undetectable
4twdJ-4feqA:
undetectable
4twdI-4feqA:
23.42
4twdJ-4feqA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
9 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.97A 4twpA-4feqA:
23.1
4twpA-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ASN A 650
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.77A 4twpA-4feqA:
23.1
4twpA-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.82A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ASN A 650
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.80A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.78A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 MET A 562
LEU A 636
HIS A 643
ALA A 662
ASP A 663
None
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.91A 4v04B-4feqA:
25.1
4v04B-4feqA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.69A 4xeyA-4feqA:
25.0
4xeyA-4feqA:
33.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.90A 5aaaA-4feqA:
20.2
5aaaA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.87A 5aabA-4feqA:
10.7
5aabA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0.67A 5aabA-4feqA:
10.7
5aabA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.91A 5aacA-4feqA:
10.6
5aacA-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0.67A 5aacA-4feqA:
10.6
5aacA-4feqA:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.71A 5ajqA-4feqA:
23.0
5ajqA-4feqA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 7 ARG A 624
MET A 657
THR A 658
LEU A 653
None
0.98A 5b3sA-4feqA:
1.2
5b3sJ-4feqA:
undetectable
5b3sA-4feqA:
20.19
5b3sJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 VAL A 574
LYS A 540
MET A 541
None
0T8  A 901 (-3.5A)
None
0.85A 5nknA-4feqA:
undetectable
5nknA-4feqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
1.30A 5w97J-4feqA:
undetectable
5w97J-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
1.37A 5wauJ-4feqA:
undetectable
5wauJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 LEU A 514
GLY A 515
VAL A 522
ALA A 538
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 ( 4.5A)
0.32A 5xv7A-4feqA:
19.2
5xv7A-4feqA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
0.99A 5z86J-4feqA:
undetectable
5z86J-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 8 ARG A 624
MET A 657
THR A 658
LEU A 653
None
0.97A 5zcoA-4feqA:
undetectable
5zcoJ-4feqA:
undetectable
5zcoA-4feqA:
20.19
5zcoJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 7 ARG A 624
MET A 657
THR A 658
LEU A 653
None
0.96A 5zcpA-4feqA:
undetectable
5zcpJ-4feqA:
undetectable
5zcpA-4feqA:
20.19
5zcpJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 7 ILE A 715
LEU A 605
ARG A 624
THR A 658
LEU A 653
None
1.50A 5zcpA-4feqA:
undetectable
5zcpJ-4feqA:
undetectable
5zcpA-4feqA:
20.19
5zcpJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.71A 5zv2B-4feqA:
25.4
5zv2B-4feqA:
13.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 6 LEU A 514
PHE A 595
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0.62A 6hd4B-4feqA:
22.2
6hd4B-4feqA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 5 ARG A 624
MET A 657
THR A 658
LEU A 653
None
1.27A 6nknW-4feqA:
undetectable
6nknW-4feqA:
11.73