SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		5 / 12 LEU A 165
ALA A 127
TYR A 116
PHE A 206
ILE A 186
 None
 1.18A 1mx8A-4ferA:
undetectable		 1mx8A-4ferA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		5 / 12 ASP A 156
PRO A  39
VAL A  67
ALA A  49
ALA A  50
 None
 1.30A 1nw5A-4ferA:
undetectable		 1nw5A-4ferA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.98A 1wmqA-4ferA:
undetectable		 1wmqA-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.98A 1wmqB-4ferA:
undetectable		 1wmqB-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 1.00A 1wpuA-4ferA:
undetectable		 1wpuA-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.99A 1wpuB-4ferA:
undetectable		 1wpuB-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.97A 1wrqA-4ferA:
undetectable		 1wrqA-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 6 ARG A  78
GLY A  79
ALA A  80
HIS A   7
 SO4  A 303 (-3.0A)
None
None
None
 0.98A 1wrqB-4ferA:
undetectable		 1wrqB-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 7 GLY A  15
THR A  70
ILE A  34
GLY A  17
 None
 0.87A 2jklD-4ferA:
undetectable		 2jklD-4ferA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 7 GLY A  15
THR A  70
ILE A  34
GLY A  17
 None
 0.87A 2jklF-4ferA:
undetectable		 2jklF-4ferA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 5 GLU A  59
PRO A  61
ILE A  91
GLY A  63
 None
 1.09A 2qeuA-4ferA:
undetectable
2qeuC-4ferA:
undetectable		 2qeuA-4ferA:
22.75
2qeuC-4ferA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 7 ASN A  86
SER A  84
TYR A  18
VAL A  67
 None
 1.17A 2uz2A-4ferA:
undetectable		 2uz2A-4ferA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 4 THR A 175
ARG A 173
GLU A 142
VAL A 181
 None
 1.03A 4odoC-4ferA:
undetectable		 4odoC-4ferA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		3 / 3 ARG A  78
ASP A  41
TYR A  44
 SO4  A 303 (-3.0A)
None
SO4  A 303 (-4.6A)
 0.95A 4yo9B-4ferA:
1.6		 4yo9B-4ferA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		4 / 5 VAL A  69
ASN A  38
ASP A  41
LEU A  51
 None
 1.25A 5m0iB-4ferA:
undetectable		 5m0iB-4ferA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		5 / 11 SER A 122
TYR A 198
VAL A 200
GLY A 202
VAL A 131
 None
 1.35A 6hu9A-4ferA:
undetectable
6hu9E-4ferA:
undetectable
6hu9I-4ferA:
undetectable		 6hu9A-4ferA:
20.14
6hu9E-4ferA:
21.89
6hu9I-4ferA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4fer EXPANSIN-YOAJ
(Bacillus
subtilis) 		5 / 10 SER A 122
TYR A 198
VAL A 200
GLY A 202
VAL A 131
 None
 1.38A 6hu9L-4ferA:
undetectable
6hu9P-4ferA:
undetectable
6hu9T-4ferA:
undetectable		 6hu9L-4ferA:
20.14
6hu9P-4ferA:
21.89
6hu9T-4ferA:
15.38