SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 12 ASN B 203
ALA B 213
VAL B 148
ALA B 147
ILE B 184
 None
 1.14A 2h42B-4fetB:
undetectable		 2h42B-4fetB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 12 LEU B 211
ALA B 213
ILE B 214
ALA B 147
ILE B 184
 None
 0.84A 2h42C-4fetB:
undetectable		 2h42C-4fetB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 12 LEU B 211
ALA B 213
VAL B 148
ALA B 147
ILE B 184
 None
 1.05A 2h42C-4fetB:
undetectable		 2h42C-4fetB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 10 VAL B 163
ALA B 164
VAL B 180
ILE B 184
VAL B 183
 None
 0.93A 2nnjA-4fetB:
undetectable		 2nnjA-4fetB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 8 GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 0.78A 2y6rB-4fetB:
undetectable		 2y6rB-4fetB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 12 ASN B 215
GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 1.26A 2y6rC-4fetB:
undetectable		 2y6rC-4fetB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 11 ASN B 215
GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 1.29A 3v3oC-4fetB:
undetectable		 3v3oC-4fetB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 10 VAL B 180
TYR B 136
ASP B 140
SER B 181
ILE B 198
 None
 1.44A 3vriA-4fetB:
undetectable
3vriC-4fetB:
undetectable		 3vriA-4fetB:
22.51
3vriC-4fetB:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 12 TYR B 226
VAL B 163
LEU B 168
ILE B 184
VAL B 180
 None
 1.18A 3w68A-4fetB:
undetectable		 3w68A-4fetB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 11 ASN B 215
GLY B 216
PRO B 133
GLY B 135
MET B 144
 None
 1.26A 4a6nC-4fetB:
undetectable		 4a6nC-4fetB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 8 SER B 234
ARG B 170
ILE B 237
TRP B 236
 None
 1.17A 4cx7A-4fetB:
undetectable
4cx7B-4fetB:
undetectable		 4cx7A-4fetB:
19.35
4cx7B-4fetB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 8 SER B 234
ARG B 170
ILE B 237
TRP B 236
 None
 1.21A 4cx7C-4fetB:
undetectable
4cx7D-4fetB:
undetectable		 4cx7C-4fetB:
19.35
4cx7D-4fetB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 7 PRO B 156
ALA B 162
PHE B 251
LYS B 244
 None
 1.01A 4lb2A-4fetB:
1.5		 4lb2A-4fetB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		5 / 6 TYR B 226
ILE B 243
VAL B 166
PRO B 219
ALA B 223
 None
 0.96A 5cu6A-4fetB:
undetectable		 5cu6A-4fetB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 7 TYR B 226
VAL B 166
PRO B 219
ALA B 223
 None
 0.79A 5osrA-4fetB:
undetectable		 5osrA-4fetB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE
(Bacillus
anthracis) 		4 / 5 TYR B 226
VAL B 166
PRO B 219
ALA B 223
 None
 0.80A 5otrA-4fetB:
undetectable		 5otrA-4fetB:
17.53