SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ff5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		4 / 7 TYR A 162
ALA A  99
TYR A  98
GLU A 133
 None
 0.81A 1dmaA-4ff5A:
undetectable		 1dmaA-4ff5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 9 GLY A  54
ASN A 224
ILE A  56
ALA A  96
VAL A  97
 None
 1.22A 2drdA-4ff5A:
undetectable		 2drdA-4ff5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		4 / 8 ASP A 204
TYR A 127
ASN A 158
GLY A 160
 None
 1.03A 2ys6A-4ff5A:
undetectable		 2ys6A-4ff5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 10 MET A 109
ALA A 112
VAL A 101
ALA A 156
ILE A 159
 None
 1.15A 3fl9A-4ff5A:
undetectable		 3fl9A-4ff5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 12 THR A 235
GLY A 160
ALA A  55
GLY A  54
GLN A  89
 None
 1.19A 3v3oA-4ff5A:
undetectable		 3v3oA-4ff5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 12 ILE A  77
HIS A  60
GLU A 108
PHE A 116
ALA A 120
 None
 1.43A 5iwuA-4ff5A:
undetectable		 5iwuA-4ff5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 12 ILE A 159
GLY A 160
VAL A 132
TYR A 117
ALA A 156
 None
 1.27A 5n0xB-4ff5A:
undetectable		 5n0xB-4ff5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		5 / 12 ILE A 214
GLY A  54
PHE A 240
ILE A  43
LEU A  34
 None
 1.08A 6dwnC-4ff5A:
0.4		 6dwnC-4ff5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4ff5 GLYCOSYL HYDROLASE
25
(Streptococcus
pneumoniae) 		6 / 12 ILE A 214
ASN A 224
GLY A  54
PHE A 240
ILE A  43
LEU A  34
 None
 1.23A 6dwnD-4ff5A:
undetectable		 6dwnD-4ff5A:
13.43