SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ffb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4ffb PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 4 LEU C  79
VAL C  77
ILE C  76
TRP C 103
 None
 1.18A 1s9qB-4ffbC:
undetectable		 1s9qB-4ffbC:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4ffb PROTEIN STU2
(Saccharomyces
cerevisiae) 		4 / 6 GLN C 122
ASN C  80
ASN C  68
LEU C  27
 None
 1.18A 2nyrA-4ffbC:
undetectable		 2nyrA-4ffbC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4ffb PROTEIN STU2
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  99
ASN C  96
LEU C 130
GLY C 132
LEU C  82
 None
 1.15A 5uc1B-4ffbC:
undetectable		 5uc1B-4ffbC:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4ffb PROTEIN STU2
(Saccharomyces
cerevisiae) 		3 / 3 GLN C 202
TYR C 164
ASN C 161
 None
 0.94A 6dwdC-4ffbC:
undetectable		 6dwdC-4ffbC:
18.63