SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ffj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4ffj RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Streptococcus
pneumoniae) 		5 / 12 GLY A 104
VAL A  45
VAL A 111
LEU A 160
PHE A 120
 None
 1.27A 1mx1E-4ffjA:
undetectable		 1mx1E-4ffjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4ffj RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Streptococcus
pneumoniae) 		5 / 12 LEU A  13
ALA A  40
MET A  48
LEU A  33
THR A 146
 None
 1.49A 1ya3B-4ffjA:
undetectable		 1ya3B-4ffjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ffj RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA
(Streptococcus
pneumoniae) 		4 / 7 ALA A 145
THR A 146
VAL A  19
HIS A 142
 None
None
None
SO4  A 301 (-4.2A)
 1.19A 5ecnA-4ffjA:
undetectable		 5ecnA-4ffjA:
16.61