SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ffk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		5 / 11 LEU A  94
LEU A  91
ILE A 172
PRO A 150
ASN A 170
 None
 0.91A 2ft9A-4ffkA:
undetectable		 2ft9A-4ffkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 TYR A  95
TRP A 143
TYR A 184
GLN A 159
 None
 1.49A 2pgzD-4ffkA:
undetectable
2pgzE-4ffkA:
undetectable		 2pgzD-4ffkA:
21.51
2pgzE-4ffkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 7 GLY A 142
HIS A  43
HIS A  47
HIS A 163
 None
FE  A 301 (-3.3A)
None
None
 1.21A 3ai8A-4ffkA:
undetectable		 3ai8A-4ffkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		3 / 3 GLY A  87
TRP A 143
VAL A 160
 None
 0.46A 3n62B-4ffkA:
undetectable		 3n62B-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		3 / 3 GLY A  87
TRP A 143
VAL A 160
 None
 0.45A 3n65B-4ffkA:
undetectable		 3n65B-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		3 / 3 GLY A  87
TRP A 143
VAL A 160
 None
 0.46A 3n66B-4ffkA:
undetectable		 3n66B-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A 114
LEU A 155
TYR A 212
GLU A 209
 None
 1.16A 3w9tB-4ffkA:
undetectable		 3w9tB-4ffkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A 114
LEU A 155
TYR A 212
GLU A 209
 None
 1.15A 3w9tE-4ffkA:
undetectable		 3w9tE-4ffkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A 114
LEU A 155
TYR A 212
GLU A 209
 None
 1.16A 3w9tF-4ffkA:
undetectable		 3w9tF-4ffkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 5 GLY A  87
ILE A  90
TRP A 143
VAL A 160
 None
 0.91A 4d33A-4ffkA:
undetectable		 4d33A-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 5 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.00A 4d33A-4ffkA:
undetectable		 4d33A-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 5 GLY A  87
ILE A  90
TRP A 143
VAL A 160
 None
 0.90A 4d33B-4ffkA:
undetectable		 4d33B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 5 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.01A 4d33B-4ffkA:
undetectable		 4d33B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A  87
ILE A  90
TRP A 143
VAL A 160
 None
 0.90A 4d39B-4ffkA:
undetectable		 4d39B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.02A 4d39B-4ffkA:
undetectable		 4d39B-4ffkA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 TYR A 195
HIS A  43
HIS A  92
TYR A  95
 None
FE  A 301 (-3.3A)
FE  A 301 (-3.2A)
None
 1.46A 4df2A-4ffkA:
undetectable		 4df2A-4ffkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		4 / 6 GLY A  88
ILE A  90
TRP A 143
VAL A 160
 None
 1.07A 4kcnA-4ffkA:
undetectable		 4kcnA-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		3 / 3 GLY A  87
TRP A 143
VAL A 160
 None
 0.45A 5vuoB-4ffkA:
undetectable		 5vuoB-4ffkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4ffk SUPEROXIDE DISMUTASE
(Acidilobus
saccharovorans) 		5 / 12 PRO A 173
ILE A 145
GLY A  87
ALA A  55
PHE A  82
 None
 1.04A 5zw4A-4ffkA:
undetectable		 5zw4A-4ffkA:
24.31