SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ffw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4ffw FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU D   4
GLY D 108
MET D  37
PHE D 103
VAL D  93
 None
 1.39A 2w8yA-4ffwD:
undetectable		 2w8yA-4ffwD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4ffw FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 SER D  21
GLY D 108
THR D 109
THR D 111
VAL D 106
 None
 1.18A 2zifA-4ffwD:
undetectable		 2zifA-4ffwD:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ffw FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR D  27
ASP D 105
ASP D 101
 None
 0.74A 3ou7B-4ffwD:
undetectable		 3ou7B-4ffwD:
23.46