SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ffy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (HEAVY
CHAIN)
DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus) 		7 / 12 TYR L  36
GLN L  89
PHE L  98
TRP H  33
VAL H  37
ALA H  97
TRP H 108
 None
 0.78A 1h8sA-4ffyL:
21.1		 1h8sA-4ffyL:
60.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus) 		5 / 9 THR L 102
LEU L  11
VAL L  13
ILE L  75
VAL L  78
 None
 1.46A 2l8mA-4ffyL:
undetectable		 2l8mA-4ffyL:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus) 		5 / 11 GLY L  66
ALA L  51
ILE L  33
ILE L   2
ASP L  30
 None
 0.89A 4dt8A-4ffyL:
undetectable		 4dt8A-4ffyL:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (HEAVY
CHAIN)
DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus;
Mus
musculus) 		5 / 12 TRP H  33
HIS H  35
PHE H 105
GLN L  89
GLN L  90
 None
 0.87A 4uilH-4ffyH:
21.4
4uilL-4ffyH:
6.2		 4uilH-4ffyH:
36.32
4uilL-4ffyH:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (HEAVY
CHAIN)
DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus) 		3 / 3 GLU H  46
TRP H  47
ASN L   1
 None
 1.15A 5dv4A-4ffyH:
undetectable		 5dv4A-4ffyH:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)
(Mus
musculus) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.01A 5l4eA-4ffyL:
undetectable
5l4eB-4ffyL:
undetectable
5l4eC-4ffyL:
undetectable
5l4eD-4ffyL:
undetectable
5l4eE-4ffyL:
undetectable		 5l4eA-4ffyL:
18.06
5l4eB-4ffyL:
18.06
5l4eC-4ffyL:
18.06
5l4eD-4ffyL:
18.06
5l4eE-4ffyL:
18.06