SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		5 / 9 LEU A 221
PHE A 218
LEU A 262
LEU A 266
ALA A 125
 None
 1.40A 2bxeA-4fg0A:
undetectable		 2bxeA-4fg0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		5 / 9 GLY A 321
ILE A 324
VAL A 375
PRO A 377
ILE A 384
 None
 1.31A 2nnhB-4fg0A:
undetectable		 2nnhB-4fg0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		3 / 3 THR A 357
SER A  29
LYS A  44
 None
 1.00A 3aocC-4fg0A:
undetectable		 3aocC-4fg0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		4 / 6 PHE A  43
LEU A 292
VAL A 186
VAL A 143
 None
 1.10A 4ek1A-4fg0A:
undetectable		 4ek1A-4fg0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		4 / 8 LEU A  23
THR A   6
ILE A 297
VAL A 295
 None
 0.90A 4eq4B-4fg0A:
undetectable		 4eq4B-4fg0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		5 / 12 VAL A 186
ILE A 297
VAL A  33
LEU A  25
PHE A  43
 None
 1.01A 4y0pA-4fg0A:
undetectable		 4y0pA-4fg0A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		5 / 12 VAL A 186
ILE A 297
VAL A  33
LEU A  25
PHE A  43
 None
 0.97A 4y0sA-4fg0A:
undetectable		 4y0sA-4fg0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		4 / 5 ASP A  95
LYS A  93
ARG A  94
ILE A 113
 None
 1.27A 5a06B-4fg0A:
undetectable		 5a06B-4fg0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		4 / 5 ASP A  95
LYS A  93
ARG A  94
ILE A 113
 None
 1.25A 5a06D-4fg0A:
undetectable		 5a06D-4fg0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		4 / 5 ASP A  95
LYS A  93
ARG A  94
ILE A 113
 None
 1.30A 5a06F-4fg0A:
undetectable		 5a06F-4fg0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4fg0 POLYPROTEIN
(Saint
Louis
encephalitis
virus) 		3 / 3 LYS A 110
VAL A  96
ASP A  98
 None
 0.63A 6fgdA-4fg0A:
undetectable		 6fgdA-4fg0A:
20.75