SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
VAL A  98
ASN A 146
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.4A)
ATP  A 401 (-4.6A)
 0.66A 1fmoE-4fg8A:
24.5		 1fmoE-4fg8A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
VAL A  98
GLU A 102
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.7A)
ATP  A 401 (-4.6A)
 0.58A 1fmoE-4fg8A:
24.5		 1fmoE-4fg8A:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.22A 1j3jA-4fg8A:
undetectable		 1j3jA-4fg8A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.13A 1nsiA-4fg8A:
undetectable
1nsiB-4fg8A:
undetectable		 1nsiA-4fg8A:
22.49
1nsiB-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.11A 1nsiA-4fg8A:
undetectable
1nsiB-4fg8A:
undetectable		 1nsiA-4fg8A:
22.49
1nsiB-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.11A 1nsiC-4fg8A:
undetectable
1nsiD-4fg8A:
undetectable		 1nsiC-4fg8A:
22.49
1nsiD-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.12A 1nsiC-4fg8A:
undetectable
1nsiD-4fg8A:
undetectable		 1nsiC-4fg8A:
22.49
1nsiD-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		3 / 3 VAL A  79
ALA A  80
HIS A  71
 ATP  A 401 (-4.7A)
None
None
 0.74A 1q23H-4fg8A:
undetectable		 1q23H-4fg8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		3 / 3 VAL A  79
ALA A  80
HIS A  71
 ATP  A 401 (-4.7A)
None
None
 0.74A 1q23G-4fg8A:
undetectable		 1q23G-4fg8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		3 / 3 VAL A  79
ALA A  80
HIS A  71
 ATP  A 401 (-4.7A)
None
None
 0.72A 1q23J-4fg8A:
undetectable		 1q23J-4fg8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 12 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.14A 1re7B-4fg8A:
undetectable		 1re7B-4fg8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 9 LEU A  26
VAL A  34
LYS A  49
LEU A  81
LEU A  93
LEU A  97
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.0A)
None
None
ATP  A 401 ( 4.8A)
 0.62A 1xkkA-4fg8A:
22.8		 1xkkA-4fg8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 11 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.16A 2blaA-4fg8A:
undetectable		 2blaA-4fg8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  98
ASP A 141
LYS A 143
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.9A)
ATP  A 401 ( 4.6A)
None
ATP  A 401 (-3.4A)
 0.76A 2fumA-4fg8A:
9.8		 2fumA-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
MET A  95
VAL A  98
LYS A 143
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
None
ATP  A 401 (-3.4A)
 0.71A 2fumB-4fg8A:
25.2		 2fumB-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
MET A  95
VAL A  98
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.4A)
 0.70A 2fumC-4fg8A:
25.4		 2fumC-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
MET A  95
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.4A)
 0.63A 2fumD-4fg8A:
25.1		 2fumD-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.13A 2nsiA-4fg8A:
undetectable
2nsiB-4fg8A:
undetectable		 2nsiA-4fg8A:
22.49
2nsiB-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.13A 2nsiA-4fg8A:
undetectable
2nsiB-4fg8A:
undetectable		 2nsiA-4fg8A:
22.49
2nsiB-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.13A 2nsiC-4fg8A:
undetectable
2nsiD-4fg8A:
undetectable		 2nsiC-4fg8A:
22.49
2nsiD-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.13A 2nsiC-4fg8A:
undetectable
2nsiD-4fg8A:
undetectable		 2nsiC-4fg8A:
22.49
2nsiD-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 LEU A 211
ILE A 158
ILE A 107
ARG A 106
 None
 0.99A 2q8hA-4fg8A:
undetectable		 2q8hA-4fg8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.12A 3e7gA-4fg8A:
undetectable
3e7gB-4fg8A:
undetectable		 3e7gA-4fg8A:
22.39
3e7gB-4fg8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.13A 3e7gA-4fg8A:
undetectable
3e7gB-4fg8A:
undetectable		 3e7gA-4fg8A:
22.39
3e7gB-4fg8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.13A 3e7gC-4fg8A:
undetectable
3e7gD-4fg8A:
undetectable		 3e7gC-4fg8A:
22.39
3e7gD-4fg8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 8 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.14A 3e7gC-4fg8A:
undetectable
3e7gD-4fg8A:
undetectable		 3e7gC-4fg8A:
22.39
3e7gD-4fg8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.17A 3ej8A-4fg8A:
undetectable
3ej8B-4fg8A:
undetectable		 3ej8A-4fg8A:
20.37
3ej8B-4fg8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.14A 3ej8A-4fg8A:
undetectable
3ej8B-4fg8A:
undetectable		 3ej8A-4fg8A:
20.37
3ej8B-4fg8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.11A 3ej8C-4fg8A:
undetectable
3ej8D-4fg8A:
undetectable		 3ej8C-4fg8A:
20.37
3ej8D-4fg8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.15A 3ej8C-4fg8A:
undetectable
3ej8D-4fg8A:
undetectable		 3ej8C-4fg8A:
20.37
3ej8D-4fg8A:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		9 / 12 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
LYS A  49
MET A  95
ASN A 146
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.4A)
ATP  A 401 (-4.6A)
 0.89A 3eygA-4fg8A:
22.8		 3eygA-4fg8A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		8 / 12 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
LYS A  49
VAL A  79
MET A  95
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 ( 4.3A)
 0.49A 3fupB-4fg8A:
22.4		 3fupB-4fg8A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 4 ILE A 276
PHE A 252
ILE A 122
THR A 280
 None
 1.02A 3ia4A-4fg8A:
undetectable		 3ia4A-4fg8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
VAL A  79
MET A  95
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 ( 4.3A)
 0.46A 3lxkA-4fg8A:
22.7		 3lxkA-4fg8A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
VAL A  98
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.69A 3lxnA-4fg8A:
22.6		 3lxnA-4fg8A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.21A 3qgtB-4fg8A:
undetectable		 3qgtB-4fg8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		3 / 3 TYR A 215
ASP A 243
ASP A 238
 None
 0.82A 3r24A-4fg8A:
undetectable		 3r24A-4fg8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 GLY A  29
VAL A  34
ALA A  47
LYS A  49
VAL A  79
LEU A 148
SER A 161
 ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
ATP  A 401 (-2.8A)
 0.77A 3v5wA-4fg8A:
9.1		 3v5wA-4fg8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
VAL A  34
ALA A  47
LYS A  49
VAL A  79
GLY A 101
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
None
ATP  A 401 (-4.6A)
 0.76A 4ag8A-4fg8A:
21.4		 4ag8A-4fg8A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 12 LYS A  49
LEU A  70
MET A  95
ASP A 141
LYS A 143
ASN A 146
 ATP  A 401 (-3.0A)
None
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.6A)
None
ATP  A 401 (-3.4A)
 1.05A 4an2A-4fg8A:
24.1		 4an2A-4fg8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 ILE A  73
VAL A  79
LEU A 148
ILE A 160
 None
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
None
 0.65A 4asdA-4fg8A:
21.2		 4asdA-4fg8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 8 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.16A 4cx7A-4fg8A:
undetectable
4cx7B-4fg8A:
undetectable		 4cx7A-4fg8A:
22.49
4cx7B-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 8 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.12A 4cx7A-4fg8A:
undetectable
4cx7B-4fg8A:
undetectable		 4cx7A-4fg8A:
22.49
4cx7B-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 8 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.11A 4cx7C-4fg8A:
undetectable
4cx7D-4fg8A:
undetectable		 4cx7C-4fg8A:
22.49
4cx7D-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.14A 4cx7C-4fg8A:
undetectable
4cx7D-4fg8A:
undetectable		 4cx7C-4fg8A:
22.49
4cx7D-4fg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 LEU A 126
LYS A 130
LEU A 271
GLU A 268
 None
 1.15A 4f3tA-4fg8A:
undetectable		 4f3tA-4fg8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.19A 4g8zX-4fg8A:
undetectable		 4g8zX-4fg8A:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 VAL A  34
ALA A  47
LEU A  81
LEU A  93
GLY A 101
GLU A 102
LEU A 148
 ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
None
None
None
ATP  A 401 (-3.7A)
ATP  A 401 (-4.6A)
 0.73A 4ifgA-4fg8A:
32.4		 4ifgA-4fg8A:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 ILE A 276
ALA A 281
PHE A 252
ILE A 122
THR A 280
 None
 1.17A 4km0A-4fg8A:
undetectable		 4km0A-4fg8A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  29
VAL A  34
LYS A  49
LEU A  97
GLY A 101
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.0A)
ATP  A 401 ( 4.8A)
None
ATP  A 401 (-4.6A)
 0.95A 4mkcA-4fg8A:
23.1		 4mkcA-4fg8A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.14A 4nosA-4fg8A:
undetectable
4nosB-4fg8A:
undetectable		 4nosA-4fg8A:
22.17
4nosB-4fg8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A 254
ILE A 245
TRP A 242
PHE A 237
 None
 1.16A 4nosC-4fg8A:
undetectable
4nosD-4fg8A:
undetectable		 4nosC-4fg8A:
22.17
4nosD-4fg8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 TRP A 242
PHE A 237
ARG A 254
ILE A 245
 None
 1.16A 4nosC-4fg8A:
undetectable
4nosD-4fg8A:
undetectable		 4nosC-4fg8A:
22.17
4nosD-4fg8A:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 11 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
ASN A 146
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-3.4A)
ATP  A 401 (-4.6A)
 0.68A 4o0sA-4fg8A:
26.9		 4o0sA-4fg8A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 VAL A  34
ALA A  47
LYS A  49
LEU A 148
 ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.6A)
 0.66A 4o0uA-4fg8A:
10.7		 4o0uA-4fg8A:
32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.6A)
 0.47A 4o0wA-4fg8A:
27.1		 4o0wA-4fg8A:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		7 / 12 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
VAL A  79
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
 0.58A 4otiA-4fg8A:
22.0		 4otiA-4fg8A:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		3 / 3 ASP A 127
HIS A  75
LYS A 130
 None
 0.92A 4qzuD-4fg8A:
undetectable		 4qzuD-4fg8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 ALA A  47
LYS A  49
LEU A  97
VAL A  98
LEU A 148
 ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 ( 4.8A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.48A 4rz7A-4fg8A:
9.7		 4rz7A-4fg8A:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 9 LEU A  26
VAL A  34
LYS A  49
ILE A  73
LEU A 148
ILE A 160
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.0A)
None
ATP  A 401 (-4.6A)
None
 1.03A 4v01B-4fg8A:
22.0		 4v01B-4fg8A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 8 LEU A  26
ALA A  47
MET A  95
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-4.6A)
 0.62A 4wboB-4fg8A:
21.4		 4wboB-4fg8A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 6 LEU A  26
ALA A  47
MET A  95
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-4.6A)
 0.66A 4wboC-4fg8A:
21.6		 4wboC-4fg8A:
23.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 11 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
 0.47A 5lvnA-4fg8A:
24.6		 5lvnA-4fg8A:
32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 10 GLY A  27
VAL A  34
ALA A  47
MET A  95
LEU A  97
 ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.8A)
 0.47A 5lw1E-4fg8A:
21.4		 5lw1E-4fg8A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		5 / 9 GLY A  27
VAL A  34
ALA A  47
MET A  95
LEU A  97
 ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.8A)
 0.53A 5lw1H-4fg8A:
18.0		 5lw1H-4fg8A:
13.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 10 LEU A  26
VAL A  34
ALA A  47
MET A  95
VAL A  98
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.82A 5n3hA-4fg8A:
24.1		 5n3hA-4fg8A:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 5 TYR A 195
VAL A 199
PRO A 261
ALA A 186
 None
 1.12A 5otrA-4fg8A:
21.8		 5otrA-4fg8A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		6 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  93
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
None
 0.61A 5yu9A-4fg8A:
22.4		 5yu9A-4fg8A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens) 		4 / 7 ARG A  41
TYR A  85
LEU A  93
TYR A  20
 None
 1.40A 6g2pA-4fg8A:
undetectable		 6g2pA-4fg8A:
23.17