SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_A_SHHA404_2 (HISTONE DEACETYLASE 8)	4fgc	NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANI NE REDUCTASE (Bacillus subtilis)	3 / 3	PRO A 113 MET A 111 TYR A 70	None	0.95A	4qa0B-4fgcA: undetectable	4qa0B-4fgcA: 17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_B_SHHB404_1 (HISTONE DEACETYLASE 8)	4fgc	NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANI NE REDUCTASE (Bacillus subtilis)	3 / 3	PRO A 113 MET A 111 TYR A 70	None	0.97A	4qa0A-4fgcA: undetectable	4qa0A-4fgcA: 17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X23_A_LSNA504_1 (CYTOCHROME P450 2C9)	4fgc	NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANI NE REDUCTASE (Bacillus subtilis)	4 / 8	PHE A 51 PHE A 122 THR A 134 PRO A 132	None	1.08A	5x23A-4fgcA: undetectable	5x23A-4fgcA: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_1 (MRNA CAPPING ENZYME P5)	4fgc	NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANI NE REDUCTASE (Bacillus subtilis)	3 / 3	TYR A 85 ASP A 28 ASP A 106	None	0.82A	5x6yA-4fgcA: undetectable	5x6yA-4fgcA: 12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A93_B_8NUB3001_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	4fgc	NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANI NE REDUCTASE (Bacillus subtilis)	4 / 5	ASP A 106 ILE A 66 PHE A 51 TYR A 25	None	1.13A	6a93B-4fgcA: undetectable	6a93B-4fgcA: 19.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4QA0_A_SHHA404_2","HISTONE DEACETYLASE 8;HISTONE DEACETYLASE 8","4fgc","NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE","Bacillus subtilis",3,"PRO A 113;MET A 111;TYR A  70","None","0.95A","4qa0B-4fgcA:undetectable","4qa0B-4fgcA:17.45"],["4QA0_B_SHHB404_1","HISTONE DEACETYLASE 8;HISTONE DEACETYLASE 8","4fgc","NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE","Bacillus subtilis",3,"PRO A 113;MET A 111;TYR A  70","None","0.97A","4qa0A-4fgcA:undetectable","4qa0A-4fgcA:17.45"],["5X23_A_LSNA504_1","CYTOCHROME P450 2C9","4fgc","NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE","Bacillus subtilis",4,"PHE A  51;PHE A 122;THR A 134;PRO A 132","None","1.08A","5x23A-4fgcA:undetectable","5x23A-4fgcA:17.30"],["5X6Y_A_SAMA902_1","MRNA CAPPING ENZYME P5","4fgc","NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE","Bacillus subtilis",3,"TYR A  85;ASP A  28;ASP A 106","None","0.82A","5x6yA-4fgcA:undetectable","5x6yA-4fgcA:12.42"],["6A93_B_8NUB3001_1","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","4fgc","NADPH-DEPENDENT 7-CYANO-7-DEAZAGUANINE REDUCTASE","Bacillus subtilis",4,"ASP A 106;ILE A  66;PHE A  51;TYR A  25","None","1.13A","6a93B-4fgcA:undetectable","6a93B-4fgcA:19.68"]]