SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QYX_A_ASDA500_1 (ESTRADIOL 17 BETA-DEHYDROGENASE 1)	4fgi	TSI1 (Pseudomonas aeruginosa)	5 / 9	VAL B 136 LEU B 163 HIS B 125 SER B 115 GLU B 127	None	1.49A	1qyxA-4fgiB: 0.0	1qyxA-4fgiB: 17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K17_B_OHBB701_0 (LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A)	4fgi	TSI1 (Pseudomonas aeruginosa)	4 / 5	GLU B 112 SER B 110 ARG B 126 SER B 107	None	0.94A	4k17B-4fgiB: 2.3	4k17B-4fgiB: 13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1F_A_3WFA501_1 (NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2)	4fgi	TSI1 (Pseudomonas aeruginosa)	5 / 12	LEU B 143 PHE B 24 HIS B 125 LEU B 113 ILE B 129	None	1.13A	4x1fA-4fgiB: undetectable	4x1fA-4fgiB: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_1 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	4fgi	TSI1 (Pseudomonas aeruginosa)	4 / 4	ASP B 78 GLY B 76 ASP B 72 ASP B 117	None	1.21A	5e72A-4fgiB: undetectable	5e72A-4fgiB: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EU9_B_REAB601_1 (RETINOIC ACID RECEPTOR)	4fgi	TSI1 (Pseudomonas aeruginosa)	6 / 10	ARG B 100 VAL B 101 LEU B 102 GLY B 98 GLY B 41 VAL B 48	None	1.13A	6eu9B-4fgiB: undetectable	6eu9B-4fgiB: 21.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QYX_A_ASDA500_1","ESTRADIOL 17 BETA-DEHYDROGENASE 1","4fgi","TSI1","Pseudomonas aeruginosa",5,"VAL B 136;LEU B 163;HIS B 125;SER B 115;GLU B 127","None","1.49A","1qyxA-4fgiB:0.0","1qyxA-4fgiB:17.74"],["4K17_B_OHBB701_0","LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A","4fgi","TSI1","Pseudomonas aeruginosa",4,"GLU B 112;SER B 110;ARG B 126;SER B 107","None","0.94A","4k17B-4fgiB:2.3","4k17B-4fgiB:13.43"],["4X1F_A_3WFA501_1","NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2","4fgi","TSI1","Pseudomonas aeruginosa",5,"LEU B 143;PHE B  24;HIS B 125;LEU B 113;ILE B 129","None","1.13A","4x1fA-4fgiB:undetectable","4x1fA-4fgiB:19.37"],["5E72_A_SAMA400_1","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","4fgi","TSI1","Pseudomonas aeruginosa",4,"ASP B  78;GLY B  76;ASP B  72;ASP B 117","None","1.21A","5e72A-4fgiB:undetectable","5e72A-4fgiB:19.16"],["6EU9_B_REAB601_1","RETINOIC ACID RECEPTOR","4fgi","TSI1","Pseudomonas aeruginosa",6,"ARG B 100;VAL B 101;LEU B 102;GLY B  98;GLY B  41;VAL B  48","None","1.13A","6eu9B-4fgiB:undetectable","6eu9B-4fgiB:21.74"]]