SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 10 LEU A 581
ALA A 381
VAL A 461
TYR A 316
LEU A 330
 None
 1.32A 1aqbA-4fgmA:
undetectable		 1aqbA-4fgmA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 PHE A 487
TYR A 491
ILE A 520
LEU A 537
 None
 0.84A 1fslB-4fgmA:
undetectable		 1fslB-4fgmA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 LEU A 581
ALA A 381
VAL A 461
TYR A 316
LEU A 330
 None
 1.30A 1hbpA-4fgmA:
undetectable		 1hbpA-4fgmA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.66A 1j36A-4fgmA:
5.5		 1j36A-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.67A 1j36B-4fgmA:
5.5		 1j36B-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.63A 1j37A-4fgmA:
5.5		 1j37A-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.64A 1j37B-4fgmA:
3.8		 1j37B-4fgmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 5 ASP A 315
SER A 311
ASP A 335
GLN A 265
 None
 1.09A 1n2xB-4fgmA:
undetectable		 1n2xB-4fgmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.65A 1o86A-4fgmA:
2.1		 1o86A-4fgmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 ASN A 108
ARG A 240
MET A 142
PRO A 143
THR A 140
 None
 1.41A 1s14A-4fgmA:
3.3		 1s14A-4fgmA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 ALA A 420
VAL A 424
TRP A 427
 None
 0.88A 1tkqA-4fgmA:
undetectable		 1tkqA-4fgmA:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 ARG A 403
LYS A 406
HIS A 181
SER A 213
 None
 1.35A 1u1jA-4fgmA:
undetectable		 1u1jA-4fgmA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.60A 2c6nA-4fgmA:
6.1		 2c6nA-4fgmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.67A 2c6nB-4fgmA:
4.0		 2c6nB-4fgmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 PHE A 155
VAL A 138
ILE A 170
PHE A 168
PHE A 106
 None
 1.23A 2dg4A-4fgmA:
undetectable		 2dg4A-4fgmA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 TYR A  41
TRP A 359
TYR A 292
HIS A 239
 None
 1.34A 2ha2B-4fgmA:
undetectable		 2ha2B-4fgmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 ASP A 314
TYR A 275
PHE A 267
LEU A 204
 None
 1.01A 2w98A-4fgmA:
undetectable
2w98B-4fgmA:
undetectable		 2w98A-4fgmA:
20.55
2w98B-4fgmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 SER A  93
HIS A 277
ASP A 314
 None
ZN  A 602 ( 3.2A)
None
 0.77A 2wa2B-4fgmA:
undetectable		 2wa2B-4fgmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.60A 2x8zA-4fgmA:
7.1		 2x8zA-4fgmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.62A 2x91A-4fgmA:
5.4		 2x91A-4fgmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 TYR A  88
GLN A  86
ILE A  51
ASP A  10
 None
 1.12A 2xytE-4fgmA:
undetectable		 2xytE-4fgmA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 7 TYR A  88
GLN A  86
ILE A  51
ASP A  10
 None
 1.18A 2xytI-4fgmA:
undetectable		 2xytI-4fgmA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 7 ILE A 183
PHE A 220
TYR A 275
THR A 210
 None
 0.98A 3ag4N-4fgmA:
undetectable
3ag4W-4fgmA:
undetectable		 3ag4N-4fgmA:
21.18
3ag4W-4fgmA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 CYH A 272
HIS A 273
PHE A 276
 None
ZN  A 602 ( 3.4A)
None
 0.93A 3cr4X-4fgmA:
undetectable		 3cr4X-4fgmA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 9 VAL A 463
TYR A 312
TYR A 316
LEU A 389
ASP A 388
 None
 1.34A 3hthB-4fgmA:
undetectable		 3hthB-4fgmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 9 VAL A 463
TYR A 312
TYR A 316
TRP A 584
ASP A 388
 None
 1.20A 3hthB-4fgmA:
undetectable		 3hthB-4fgmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 4 GLY A 517
VAL A 500
GLY A 497
THR A 529
 None
 0.92A 3ib2A-4fgmA:
undetectable		 3ib2A-4fgmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 HIS A 273
GLU A 274
HIS A 277
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
 0.22A 3kecB-4fgmA:
5.4		 3kecB-4fgmA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 TYR A 312
VAL A 404
THR A 400
PHE A 313
 None
 1.34A 3ltwA-4fgmA:
undetectable		 3ltwA-4fgmA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 GLY A 308
TRP A 304
VAL A 351
 None
 0.59A 3n62B-4fgmA:
undetectable		 3n62B-4fgmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 GLY A 308
TRP A 304
VAL A 351
 None
 0.62A 3n65B-4fgmA:
undetectable		 3n65B-4fgmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 GLY A 308
TRP A 304
VAL A 351
 None
 0.59A 3n66B-4fgmA:
undetectable		 3n66B-4fgmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 ILE A 548
ALA A 512
PHE A 487
LEU A 514
ILE A 536
 None
 0.93A 3oapA-4fgmA:
undetectable		 3oapA-4fgmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 PHE A 105
THR A 109
ILE A 164
LEU A 125
HIS A 239
 None
 0.99A 3sp9A-4fgmA:
undetectable		 3sp9A-4fgmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 PHE A 105
THR A 109
ILE A 164
LEU A 125
HIS A 239
 None
 1.01A 3sp9B-4fgmA:
undetectable		 3sp9B-4fgmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 HIS A 128
GLU A 124
ASP A   5
GLU A  23
 None
 1.28A 3vywA-4fgmA:
undetectable		 3vywA-4fgmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 10 ALA A 489
LEU A 561
LEU A 514
LEU A 498
ILE A 548
 None
 1.16A 3wdmB-4fgmA:
undetectable		 3wdmB-4fgmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 9 ALA A 489
LEU A 561
LEU A 514
LEU A 498
ILE A 548
 None
 1.08A 3wdmC-4fgmA:
undetectable		 3wdmC-4fgmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 10 ALA A 489
LEU A 561
LEU A 514
LEU A 498
ILE A 548
 None
 1.16A 3wdmD-4fgmA:
undetectable		 3wdmD-4fgmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 LEU A 245
THR A 224
TYR A 275
TYR A 223
 None
 1.22A 3wipF-4fgmA:
undetectable
3wipJ-4fgmA:
undetectable		 3wipF-4fgmA:
16.19
3wipJ-4fgmA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 5 HIS A 239
HIS A 273
GLU A 274
HIS A 277
 None
ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
 1.10A 4a7bB-4fgmA:
5.6		 4a7bB-4fgmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 11 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.66A 4c2pA-4fgmA:
6.7		 4c2pA-4fgmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 9 GLY A 235
HIS A 273
GLU A 274
GLU A 307
TYR A 377
 None
ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.68A 4dprA-4fgmA:
20.1		 4dprA-4fgmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 ASN A 429
MET A 405
MET A 309
LEU A 387
 None
 1.13A 4okxA-4fgmA:
undetectable		 4okxA-4fgmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 THR A 419
THR A 310
HIS A 277
LEU A 284
 None
ZN  A 602 ( 4.8A)
ZN  A 602 ( 3.2A)
None
 0.98A 4pgfA-4fgmA:
undetectable		 4pgfA-4fgmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 8 PHE A 362
TYR A  41
GLY A 308
ILE A 383
 None
 0.90A 4qoiA-4fgmA:
undetectable
4qoiB-4fgmA:
undetectable		 4qoiA-4fgmA:
17.42
4qoiB-4fgmA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 GLU A 274
HIS A 277
GLU A 307
TYR A 363
TYR A 377
 MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
None
MAE  A 601 (-4.7A)
 0.86A 4r7lA-4fgmA:
18.2		 4r7lA-4fgmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 HIS A 273
GLU A 274
HIS A 277
GLU A 307
TYR A 377
 ZN  A 602 ( 3.4A)
MAE  A 601 ( 3.5A)
ZN  A 602 ( 3.2A)
ZN  A 602 ( 2.3A)
MAE  A 601 (-4.7A)
 0.36A 4r7lA-4fgmA:
18.2		 4r7lA-4fgmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 5 LEU A 391
ASP A 388
TYR A 431
LEU A 428
 None
 1.27A 4wozF-4fgmA:
undetectable
4wozH-4fgmA:
undetectable		 4wozF-4fgmA:
18.74
4wozH-4fgmA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 7 LEU A 214
THR A 320
LEU A 317
THR A 400
 None
 0.90A 4z90A-4fgmA:
4.9
4z90B-4fgmA:
undetectable
4z90C-4fgmA:
4.8
4z90D-4fgmA:
4.7
4z90E-4fgmA:
undetectable		 4z90A-4fgmA:
20.84
4z90B-4fgmA:
20.84
4z90C-4fgmA:
20.84
4z90D-4fgmA:
20.84
4z90E-4fgmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 6 ILE A 183
PHE A 220
TYR A 275
THR A 210
 None
 0.96A 5b1aN-4fgmA:
undetectable
5b1aW-4fgmA:
undetectable		 5b1aN-4fgmA:
21.18
5b1aW-4fgmA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 7 SER A  93
ASP A  91
PHE A  46
SER A  40
 None
None
None
MAE  A 601 ( 3.7A)
 1.21A 5l1fC-4fgmA:
undetectable		 5l1fC-4fgmA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 4 HIS A 277
HIS A 273
TYR A 377
GLU A 307
 ZN  A 602 ( 3.2A)
ZN  A 602 ( 3.4A)
MAE  A 601 (-4.7A)
ZN  A 602 ( 2.3A)
 1.49A 5pahA-4fgmA:
undetectable		 5pahA-4fgmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 9 ILE A 324
LYS A 206
ILE A 207
LEU A 214
 None
 0.84A 5vkqB-4fgmA:
undetectable
5vkqC-4fgmA:
undetectable		 5vkqB-4fgmA:
15.61
5vkqC-4fgmA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		3 / 3 GLY A 308
TRP A 304
VAL A 351
 None
 0.60A 5vuoB-4fgmA:
undetectable		 5vuoB-4fgmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		4 / 5 ILE A 183
PHE A 220
TYR A 275
THR A 210
 None
 0.97A 5z84N-4fgmA:
undetectable
5z84W-4fgmA:
undetectable		 5z84N-4fgmA:
21.18
5z84W-4fgmA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 ILE A 548
ALA A 512
PHE A 487
LEU A 514
ILE A 536
 None
 0.96A 6a5yD-4fgmA:
undetectable		 6a5yD-4fgmA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4fgm AMINOPEPTIDASE N
FAMILY PROTEIN
(Idiomarina
loihiensis) 		5 / 12 ILE A   6
THR A 140
VAL A 138
TRP A 152
LEU A  15
 None
 1.32A 6djzB-4fgmA:
undetectable		 6djzB-4fgmA:
18.43