SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 VAL A 141
VAL A  32
TRP A  30
 None
 0.55A 1av2A-4fguA:
undetectable
1av2B-4fguA:
undetectable		 1av2A-4fguA:
2.88
1av2B-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4fgu LEGUMAIN
(Homo
sapiens) 		5 / 12 LEU A 366
LEU A 411
VAL A 407
SER A 424
VAL A 363
 None
 1.04A 1ie9A-4fguA:
undetectable		 1ie9A-4fguA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		5 / 11 TYR A 144
ILE A 143
MET A 195
LEU A 154
VAL A 258
 None
 1.35A 1mrlA-4fguA:
undetectable
1mrlB-4fguA:
undetectable		 1mrlA-4fguA:
15.94
1mrlB-4fguA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		5 / 12 TYR A 144
ILE A 143
MET A 195
LEU A 154
VAL A 258
 None
 1.31A 1mrlB-4fguA:
undetectable
1mrlC-4fguA:
undetectable		 1mrlB-4fguA:
15.94
1mrlC-4fguA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4fgu LEGUMAIN
(Homo
sapiens) 		5 / 12 VAL A 407
LEU A 408
LEU A 356
LEU A 411
LEU A 355
 None
 0.88A 1mx1F-4fguA:
undetectable		 1mx1F-4fguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 VAL A 141
VAL A  32
TRP A  30
 None
 0.74A 1w5uA-4fguA:
undetectable
1w5uB-4fguA:
undetectable		 1w5uA-4fguA:
2.88
1w5uB-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 VAL A  32
TRP A  30
VAL A 141
 None
 0.66A 2izqC-4fguA:
undetectable
2izqD-4fguA:
undetectable		 2izqC-4fguA:
2.88
2izqD-4fguA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 ILE A  56
PHE A 142
HIS A  51
 None
 0.59A 3h0aA-4fguA:
undetectable		 3h0aA-4fguA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fgu LEGUMAIN
(Homo
sapiens) 		4 / 8 GLU A 187
SER A 307
ALA A 209
ALA A 210
 None
 0.91A 3ns1L-4fguA:
undetectable		 3ns1L-4fguA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 LEU A 246
MET A 286
ASP A  48
 None
 0.67A 4j7xB-4fguA:
4.8		 4j7xB-4fguA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		4 / 6 THR A 332
LEU A 339
ASP A 340
LEU A 312
 None
 1.02A 4wozA-4fguA:
undetectable
4wozB-4fguA:
undetectable		 4wozA-4fguA:
19.50
4wozB-4fguA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		4 / 5 LEU A 339
ASP A 340
LEU A 312
THR A 332
 None
 1.03A 4wozF-4fguA:
undetectable
4wozH-4fguA:
1.7		 4wozF-4fguA:
19.50
4wozH-4fguA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4fgu LEGUMAIN
(Homo
sapiens) 		4 / 4 ASN A 211
SER A 215
ALA A 210
VAL A 267
 None
 1.39A 4x1kC-4fguA:
2.6		 4x1kC-4fguA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 LYS A  28
HIS A  29
HIS A 140
 None
 1.34A 5oexA-4fguA:
undetectable		 5oexA-4fguA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 LYS A  28
HIS A  29
HIS A 140
 None
 1.32A 5oexB-4fguA:
undetectable		 5oexB-4fguA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 LYS A  28
HIS A  29
HIS A 140
 None
 1.32A 5oexC-4fguA:
undetectable		 5oexC-4fguA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		3 / 3 LYS A  28
HIS A  29
HIS A 140
 None
 1.32A 5oexD-4fguA:
undetectable		 5oexD-4fguA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		4 / 8 ASP A 309
THR A 313
LEU A 312
TYR A 400
 None
 1.21A 5ov9B-4fguA:
2.5		 5ov9B-4fguA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4fgu LEGUMAIN
(Homo
sapiens) 		5 / 12 ALA A  49
VAL A  68
GLY A  98
VAL A  31
ILE A  33
 None
 0.88A 6dj1A-4fguA:
undetectable		 6dj1A-4fguA:
9.83