SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 LEU A 339
TYR A 357
HIS A 336
THR A 249
 None
 0.92A 1afsA-4fgvA:
undetectable		 1afsA-4fgvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 LEU A 339
TYR A 357
HIS A 336
THR A 249
 None
 0.92A 1afsB-4fgvA:
undetectable		 1afsB-4fgvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 ARG A 731
ALA A 730
ASP A 732
GLY A 733
 None
 1.21A 1e7cA-4fgvA:
undetectable		 1e7cA-4fgvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 ILE A 270
PHE A 273
TYR A 406
HIS A 336
TYR A 357
 None
 1.44A 1fm6X-4fgvA:
undetectable		 1fm6X-4fgvA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 PHE A 596
TRP A 556
GLU A 603
 None
 1.11A 1mogA-4fgvA:
undetectable		 1mogA-4fgvA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 PHE A 331
PHE A 316
PHE A 273
SER A 281
 None
 1.07A 1wrlE-4fgvA:
undetectable		 1wrlE-4fgvA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 ASN A 492
TRP A 496
GLN A 480
 None
 1.42A 1xoqA-4fgvA:
undetectable		 1xoqA-4fgvA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 GLY A 733
VAL A 789
ASP A 732
ALA A 736
ARG A 731
 None
 1.31A 2avdB-4fgvA:
undetectable		 2avdB-4fgvA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 6 PHE A 240
GLN A 246
ASN A 307
LEU A 254
 None
 1.20A 2nyrA-4fgvA:
undetectable		 2nyrA-4fgvA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 LEU A 107
ASN A 108
LEU A 106
VAL A  86
LEU A 114
 None
 1.12A 2q7kA-4fgvA:
undetectable		 2q7kA-4fgvA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 THR A1003
PHE A1010
VAL A 986
GLY A 987
ALA A 983
 None
 1.19A 2x2iA-4fgvA:
undetectable		 2x2iA-4fgvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 LEU A 777
GLY A 776
LEU A 778
ILE A 804
LEU A 808
 None
 1.04A 3gwvA-4fgvA:
undetectable		 3gwvA-4fgvA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 702
GLY A 635
ALA A 695
ALA A 640
GLN A 647
 None
 1.25A 3nmuA-4fgvA:
undetectable
3nmuF-4fgvA:
undetectable		 3nmuA-4fgvA:
17.48
3nmuF-4fgvA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 11 TYR A 702
GLY A 635
ALA A 695
ALA A 640
GLN A 647
 None
 1.12A 3nmuB-4fgvA:
1.5
3nmuJ-4fgvA:
undetectable		 3nmuB-4fgvA:
17.48
3nmuJ-4fgvA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 702
GLY A 635
ALA A 695
ALA A 640
GLN A 647
 None
 1.03A 3nvkF-4fgvA:
undetectable
3nvkJ-4fgvA:
undetectable		 3nvkF-4fgvA:
17.48
3nvkJ-4fgvA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 10 ILE A 221
PHE A 222
ILE A 227
LEU A 269
HIS A 319
 None
 1.21A 3o1cA-4fgvA:
undetectable		 3o1cA-4fgvA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 10 ILE A 221
PHE A 222
ILE A 227
LEU A 269
HIS A 319
 None
 1.18A 3o1xA-4fgvA:
undetectable		 3o1xA-4fgvA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 10 ILE A 221
PHE A 222
ILE A 227
LEU A 269
HIS A 319
 None
 1.18A 3qgzA-4fgvA:
undetectable		 3qgzA-4fgvA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 ALA A 652
ASN A 659
ARG A 709
PRO A 705
 None
 1.18A 3vxiA-4fgvA:
0.0		 3vxiA-4fgvA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 VAL A 789
GLY A 791
TYR A 785
ASP A 794
 None
 1.32A 3w9tA-4fgvA:
undetectable		 3w9tA-4fgvA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 VAL A 789
GLY A 791
TYR A 785
ASP A 794
 None
 1.32A 3w9tF-4fgvA:
undetectable		 3w9tF-4fgvA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 4 ASN A 194
SER A 200
LEU A 201
THR A 229
 None
 1.14A 4an2A-4fgvA:
undetectable		 4an2A-4fgvA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 543
VAL A 493
ALA A 497
SER A 500
LEU A 458
 None
 1.15A 4coxA-4fgvA:
undetectable		 4coxA-4fgvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 543
VAL A 493
ALA A 497
SER A 500
LEU A 458
 None
 1.14A 4coxB-4fgvA:
undetectable		 4coxB-4fgvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 543
VAL A 493
ALA A 497
SER A 500
LEU A 458
 None
 1.14A 4coxC-4fgvA:
undetectable		 4coxC-4fgvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 TYR A 543
VAL A 493
ALA A 497
SER A 500
LEU A 458
 None
 1.15A 4coxD-4fgvA:
undetectable		 4coxD-4fgvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 SER A 411
GLU A 475
ILE A 472
ASN A 412
 None
 0.94A 4d33B-4fgvA:
undetectable		 4d33B-4fgvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 VAL A 797
MET A 801
GLU A 757
LEU A 777
 None
 1.10A 4hojA-4fgvA:
2.8		 4hojA-4fgvA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 LYS A1068
PRO A1069
SER A1070
 None
 0.32A 4k50I-4fgvA:
0.6		 4k50I-4fgvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 11 GLY A 389
GLY A 388
GLY A 387
ALA A 504
HIS A 463
 None
 1.13A 4l8fB-4fgvA:
undetectable		 4l8fB-4fgvA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 11 GLY A 389
GLY A 388
GLY A 387
ALA A 504
HIS A 463
 None
 1.12A 4l8fD-4fgvA:
undetectable		 4l8fD-4fgvA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 8 GLU A 303
GLN A 246
THR A 208
ARG A 211
 None
 1.13A 4lnwA-4fgvA:
undetectable		 4lnwA-4fgvA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 6 GLU A 303
GLN A 246
THR A 208
ARG A 211
 None
 1.07A 4lnxA-4fgvA:
undetectable		 4lnxA-4fgvA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 ILE A 498
LEU A 477
ASP A 520
THR A 525
 None
 1.06A 4mmcA-4fgvA:
undetectable		 4mmcA-4fgvA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 SER A 780
VAL A 823
MET A 801
LEU A 715
TYR A 711
 None
 1.27A 4o8fB-4fgvA:
undetectable		 4o8fB-4fgvA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 LEU A 372
LEU A 374
GLY A 383
HIS A 463
MET A 385
 None
 1.40A 4olmA-4fgvA:
undetectable		 4olmA-4fgvA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 GLY A 700
PRO A 701
GLN A 647
 None
 0.50A 4oltB-4fgvA:
undetectable		 4oltB-4fgvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 GLY A 700
PRO A 701
GLN A 647
 None
 0.56A 4qwpB-4fgvA:
undetectable		 4qwpB-4fgvA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 7 GLU A 324
TYR A 357
LEU A 339
TYR A 406
 None
 1.15A 4twdF-4fgvA:
3.4
4twdJ-4fgvA:
undetectable		 4twdF-4fgvA:
16.25
4twdJ-4fgvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 ASP A 834
ARG A 793
PRO A 790
 None
 0.93A 4wanC-4fgvA:
undetectable		 4wanC-4fgvA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 11 LEU A 361
GLU A 367
LEU A 365
LEU A 464
LEU A 410
 None
 1.17A 4wg0G-4fgvA:
undetectable
4wg0H-4fgvA:
undetectable
4wg0I-4fgvA:
undetectable		 4wg0G-4fgvA:
1.20
4wg0H-4fgvA:
1.20
4wg0I-4fgvA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		5 / 12 SER A 343
PHE A 315
PHE A 316
THR A 317
LEU A 277
 None
 1.43A 4z7fC-4fgvA:
undetectable		 4z7fC-4fgvA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 8 ALA A 736
THR A 737
VAL A 742
VAL A 789
 None
 0.88A 5ecnD-4fgvA:
undetectable		 5ecnD-4fgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 6 PHE A 607
PRO A 606
ARG A 613
ILE A 608
 None
 1.20A 5ih0A-4fgvA:
undetectable		 5ih0A-4fgvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 4 GLN A 641
VAL A 597
GLU A 609
ILE A 608
 None
 1.33A 5jncA-4fgvA:
undetectable		 5jncA-4fgvA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 ASP A 713
ASN A 692
GLN A 706
 None
 0.59A 5k7uA-4fgvA:
undetectable		 5k7uA-4fgvA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 6 ASP A 713
ARG A 709
ASN A 692
GLN A 706
 None
 1.23A 5l6eA-4fgvA:
undetectable		 5l6eA-4fgvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW3_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 4 GLN A 246
LEU A 310
ASN A 307
GLN A 306
 None
 1.43A 5vw3A-4fgvA:
0.5		 5vw3A-4fgvA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 6 PHE A  85
ARG A  83
ALA A  39
GLN A  80
 None
 1.07A 6b89B-4fgvA:
undetectable		 6b89B-4fgvA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		4 / 5 TYR A 161
GLN A 165
THR A 171
LEU A 174
 None
 1.12A 6d8pA-4fgvA:
undetectable		 6d8pA-4fgvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)
(Chaetomium
thermophilum) 		3 / 3 ARG A 842
PHE A 870
PHE A 835
 None
 0.95A 6nknC-4fgvA:
2.1
6nknJ-4fgvA:
undetectable		 6nknC-4fgvA:
13.10
6nknJ-4fgvA:
4.17