SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 301
GLY A 340
THR A 343
GLY A 153
 None
 0.86A 1jr1B-4fgwA:
undetectable		 1jr1B-4fgwA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 227
GLU A  55
TYR A 226
THR A  48
 None
 1.25A 1rmtB-4fgwA:
2.8		 1rmtB-4fgwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 342
LEU A 250
ALA A 338
GLU A 329
 None
 1.06A 1xvaA-4fgwA:
4.2
1xvaB-4fgwA:
3.7		 1xvaA-4fgwA:
21.20
1xvaB-4fgwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 355
GLY A 157
PHE A 279
PHE A 360
 None
 0.96A 2qwxA-4fgwA:
5.1
2qwxB-4fgwA:
5.2		 2qwxA-4fgwA:
20.51
2qwxB-4fgwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 272
GLY A 274
ALA A 267
LEU A 244
PHE A 279
LEU A 362
 None
 1.32A 3mteB-4fgwA:
3.6		 3mteB-4fgwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 272
GLY A 274
ALA A 267
LEU A 244
PHE A 279
LEU A 362
 None
 1.37A 3p2kA-4fgwA:
3.9		 3p2kA-4fgwA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 6 THR A 197
SER A 287
TYR A 292
ASP A 301
 None
 1.11A 3q70A-4fgwA:
undetectable		 3q70A-4fgwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 238
THR A 197
THR A 196
SER A 296
 None
 1.14A 3snfA-4fgwA:
undetectable		 3snfA-4fgwA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A  84
MET A  70
PRO A 109
GLU A  74
VAL A 106
 None
 1.23A 3ua5A-4fgwA:
1.5		 3ua5A-4fgwA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 256
GLY A 253
SER A 265
 None
 0.71A 4b53B-4fgwA:
undetectable		 4b53B-4fgwA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 235
ARG A 146
ILE A 148
ALA A 147
 None
 0.88A 4lv9B-4fgwA:
undetectable		 4lv9B-4fgwA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 244
LEU A 163
ALA A 178
ALA A 236
GLY A 153
 None
 1.21A 4rn6A-4fgwA:
undetectable		 4rn6A-4fgwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 179
ALA A 297
ASP A 301
SER A 296
ALA A 300
 None
 1.29A 4wnuB-4fgwA:
1.0		 4wnuB-4fgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 168
ARG A 132
LEU A 111
ILE A 125
 None
 0.92A 4xumA-4fgwA:
undetectable		 4xumA-4fgwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 198
THR A 196
LEU A 221
VAL A  52
 None
 0.96A 5e4dA-4fgwA:
undetectable
5e4dB-4fgwA:
undetectable		 5e4dA-4fgwA:
19.27
5e4dB-4fgwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 344
LYS A 345
HIS A 348
 None
 0.77A 5js5A-4fgwA:
undetectable		 5js5A-4fgwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 298
VAL A 347
GLY A 280
SER A 287
ILE A 240
 None
 1.17A 5vooD-4fgwA:
undetectable		 5vooD-4fgwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 298
VAL A 347
GLY A 280
SER A 287
ILE A 240
 None
 1.17A 5vooE-4fgwA:
undetectable		 5vooE-4fgwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 298
VAL A 347
GLY A 280
SER A 287
ILE A 240
 None
 1.15A 5vooF-4fgwA:
3.9		 5vooF-4fgwA:
21.10