SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 7 PHE A  39
SER A  57
ALA A  55
ILE A  54
 None
 1.06A 1fxhA-4fh8A:
undetectable
1fxhB-4fh8A:
undetectable		 1fxhA-4fh8A:
24.07
1fxhB-4fh8A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		5 / 11 VAL A  26
LEU A  71
THR A  15
HIS A  81
TYR A  41
 None
 1.21A 1mmtA-4fh8A:
undetectable		 1mmtA-4fh8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.85A 1p7lC-4fh8A:
undetectable		 1p7lC-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.86A 1p7lD-4fh8A:
undetectable		 1p7lD-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.85A 1rg9A-4fh8A:
undetectable		 1rg9A-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.86A 1rg9B-4fh8A:
undetectable		 1rg9B-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.85A 1rg9C-4fh8A:
undetectable		 1rg9C-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.86A 1rg9D-4fh8A:
undetectable		 1rg9D-4fh8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 7 ILE A 130
TYR A  35
PHE A 160
ASP A 164
 None
 1.15A 2qebA-4fh8A:
undetectable		 2qebA-4fh8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 4 LEU A  66
ASP A 131
VAL A  37
THR A 153
 None
 1.19A 3cyxB-4fh8A:
undetectable		 3cyxB-4fh8A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		5 / 12 TYR A  41
PHE A  45
SER A  80
VAL A  18
PHE A  23
 None
 1.37A 3nbrA-4fh8A:
undetectable		 3nbrA-4fh8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		5 / 10 THR A  75
GLY A 121
ILE A 109
GLN A 108
ALA A 110
 None
 1.02A 5l0zB-4fh8A:
3.2		 5l0zB-4fh8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4fh8 ACEPRX-1
(Ancylostoma
ceylanicum) 		4 / 8 PRO A  11
THR A  75
PHE A  40
ASP A 112
 None
 0.97A 5t8sB-4fh8A:
undetectable		 5t8sB-4fh8A:
23.08