SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 ASN A 216
ASP A 194
PRO A 257
ALA A 260
ILE A 261
 None
 1.07A 1aj6A-4fhaA:
undetectable		 1aj6A-4fhaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  46
TYR A 190
GLY A 107
ALA A 106
GLY A 103
 None
 1.12A 1igxA-4fhaA:
undetectable		 1igxA-4fhaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A  57
GLU A  61
ALA A  68
ARG A 273
PHE A  19
 None
 1.21A 1l5rA-4fhaA:
2.0		 1l5rA-4fhaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A 164
PHE A 187
THR A 151
LEU A 150
 None
 0.92A 2eikN-4fhaA:
undetectable
2eikW-4fhaA:
undetectable		 2eikN-4fhaA:
21.36
2eikW-4fhaA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 104
ALA A  81
ALA A  48
THR A  17
 None
 0.94A 2wx2A-4fhaA:
undetectable		 2wx2A-4fhaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 THR A  13
ILE A  34
LEU A  38
THR A  42
 None
 0.84A 3deuB-4fhaA:
undetectable		 3deuB-4fhaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 MET A 155
ILE A 139
TYR A 140
ILE A 138
 None
None
KPI  A 168 ( 3.8A)
None
 0.99A 3hgxA-4fhaA:
undetectable		 3hgxA-4fhaA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 105
ILE A  80
GLY A 107
LEU A   6
LEU A 188
 None
 0.98A 3kw2A-4fhaA:
2.3		 3kw2A-4fhaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 104
ALA A  81
ALA A  48
THR A  17
 None
 0.99A 3l4dD-4fhaA:
undetectable		 3l4dD-4fhaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  37
ILE A  16
VAL A 258
LEU A 262
ALA A 212
 None
 1.04A 4o1zB-4fhaA:
undetectable		 4o1zB-4fhaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASN A 216
ASP A 194
PRO A 257
ALA A 260
ILE A 261
 None
 1.05A 4uroC-4fhaA:
undetectable		 4uroC-4fhaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  15
ILE A  34
ASP A  43
GLY A  44
 None
 0.74A 5h3aA-4fhaA:
undetectable		 5h3aA-4fhaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 198
ILE A 227
ASP A 206
GLY A 207
 None
 0.88A 5h3aA-4fhaA:
undetectable		 5h3aA-4fhaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  15
ILE A  34
ASP A  43
GLY A  44
 None
 0.78A 5h3aB-4fhaA:
undetectable		 5h3aB-4fhaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  57
LEU A 262
MET A 265
ALA A  14
LEU A  37
 None
None
None
KPI  A 168 ( 3.5A)
None
 1.32A 5ienA-4fhaA:
undetectable		 5ienA-4fhaA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 207
ILE A 227
ALA A 197
ASP A 206
ALA A 205
 None
 1.22A 5kvaB-4fhaA:
undetectable		 5kvaB-4fhaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  90
LEU A 150
HIS A 125
GLY A  82
LEU A 108
 None
 1.16A 5m50E-4fhaA:
2.9		 5m50E-4fhaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 SER A 254
THR A 215
ASP A 218
ASP A 194
 None
 1.44A 5vimA-4fhaA:
undetectable		 5vimA-4fhaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 SER A 254
THR A 215
ASP A 218
ASP A 194
 None
 1.43A 5vimB-4fhaA:
undetectable		 5vimB-4fhaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  15
ILE A  34
ASP A  43
GLY A  44
 None
 0.79A 5x5qC-4fhaA:
undetectable		 5x5qC-4fhaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 PHE A  15
ILE A  34
ASP A  43
GLY A  44
 None
 0.84A 5x5qE-4fhaA:
undetectable		 5x5qE-4fhaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 PHE A 198
ILE A 227
ASP A 206
GLY A 207
 None
 0.98A 5x5qE-4fhaA:
undetectable		 5x5qE-4fhaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 PHE A  94
GLU A  97
ASP A  90
HIS A  59
 None
None
None
LYS  A 401 (-3.8A)
 1.49A 6b58C-4fhaA:
0.0		 6b58C-4fhaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4fha DIHYDRODIPICOLINATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 204
LEU A 203
ALA A 177
GLU A 181
 None
 0.81A 6mdqA-4fhaA:
undetectable		 6mdqA-4fhaA:
13.86