SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fhn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 4 THR B 938
LEU B 942
LEU B 978
GLN B 981
 None
 0.89A 1fbmA-4fhnB:
undetectable		 1fbmA-4fhnB:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU B 867
LEU B 895
ILE B 885
HIS B 901
LEU B 902
 None
 1.16A 1g50A-4fhnB:
undetectable		 1g50A-4fhnB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE B 349
ILE B 332
LYS B 313
ALA B 298
 None
 1.16A 1hk2A-4fhnB:
undetectable		 1hk2A-4fhnB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU B 881
LEU B 847
ALA B 846
LEU B 850
 None
 1.00A 1hwiB-4fhnB:
undetectable		 1hwiB-4fhnB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU B 881
LEU B 847
ALA B 846
LEU B 850
 None
 1.00A 1hwiC-4fhnB:
undetectable		 1hwiC-4fhnB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP B 682
GLU B 553
GLU B 549
GLU B   3
 None
 1.04A 1knyA-4fhnB:
undetectable
1knyB-4fhnB:
1.1		 1knyA-4fhnB:
12.94
1knyB-4fhnB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU B   3
ASP B 682
GLU B 553
GLU B 549
 None
 0.96A 1knyA-4fhnB:
undetectable
1knyB-4fhnB:
1.1		 1knyA-4fhnB:
12.94
1knyB-4fhnB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 867
LEU B 895
ILE B 885
HIS B 901
LEU B 902
 None
 1.16A 1pcgA-4fhnB:
undetectable		 1pcgA-4fhnB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU B 920
SER B 919
THR B 944
ALA B 953
ALA B 954
 None
 0.77A 1wygA-4fhnB:
undetectable		 1wygA-4fhnB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 ALA B  59
ALA B  56
TYR B  57
GLN B 437
 None
 1.08A 1xl6A-4fhnB:
undetectable
1xl6B-4fhnB:
undetectable		 1xl6A-4fhnB:
14.70
1xl6B-4fhnB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE B 885
LEU B 933
ALA B 936
GLU B 940
 None
 1.34A 1xvaA-4fhnB:
undetectable
1xvaB-4fhnB:
undetectable		 1xvaA-4fhnB:
12.92
1xvaB-4fhnB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 TRP B 834
LEU B 835
LYS B 845
 None
 1.47A 1yajK-4fhnB:
2.1		 1yajK-4fhnB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN B 771
LYS B 818
VAL B 816
 None
 0.89A 2jfaB-4fhnB:
undetectable		 2jfaB-4fhnB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE B 551
ARG B 581
GLN B 689
LEU B 599
 None
 1.07A 2nyrA-4fhnB:
undetectable		 2nyrA-4fhnB:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP B 525
VAL B 530
TYR B 532
VAL B  88
ASN B  91
 None
 1.50A 2x0yA-4fhnB:
undetectable		 2x0yA-4fhnB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR B  57
GLU B 434
ASN B 101
 None
 0.97A 2y7hC-4fhnB:
2.1		 2y7hC-4fhnB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 SER B 186
MET B 111
PHE B 167
ILE B 131
LEU B 254
 None
 1.48A 3aocC-4fhnB:
undetectable		 3aocC-4fhnB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU B 916
SER B 919
ALA B 954
ALA B 957
 None
 1.03A 3ax9B-4fhnB:
undetectable		 3ax9B-4fhnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU B 920
SER B 919
ALA B 953
ALA B 954
 None
 1.02A 3ax9B-4fhnB:
undetectable		 3ax9B-4fhnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 7 THR B1081
LEU B1102
LEU B1073
LEU B1105
 None
 0.85A 3bgdB-4fhnB:
undetectable		 3bgdB-4fhnB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA B 202
TYR B 129
LEU B 137
ILE B 165
MET B 175
 None
 1.35A 3qt0A-4fhnB:
undetectable		 3qt0A-4fhnB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU B 258
THR B 292
THR B 293
ILE B 352
ILE B 311
 None
 1.16A 3sp9A-4fhnB:
undetectable		 3sp9A-4fhnB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 SER B 738
ASP B 682
ASP B 552
ILE B 548
 None
 1.33A 3uj7B-4fhnB:
undetectable		 3uj7B-4fhnB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP B1000
ASP B1080
ASN B1032
GLU B1004
 None
 0.92A 4feuD-4fhnB:
1.5		 4feuD-4fhnB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU B 867
LEU B 895
ILE B 885
HIS B 901
LEU B 902
 None
 1.18A 4j24B-4fhnB:
undetectable		 4j24B-4fhnB:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU B 270
LYS B 322
ASN B 324
 None
 0.98A 4y1dA-4fhnB:
undetectable
4y1dD-4fhnB:
undetectable		 4y1dA-4fhnB:
8.83
4y1dD-4fhnB:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU B 440
ILE B 426
GLU B 501
TRP B 502
LEU B 471
 None
 1.49A 4yvpA-4fhnB:
undetectable		 4yvpA-4fhnB:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP B  87
GLU B  19
SER B 527
 None
 0.86A 5bw4B-4fhnB:
undetectable		 5bw4B-4fhnB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU B 466
PHE B 427
ILE B 436
ILE B 426
 None
 1.08A 5dzk4-4fhnB:
undetectable
5dzkg-4fhnB:
undetectable
5dzkm-4fhnB:
undetectable
5dzkn-4fhnB:
undetectable		 5dzk4-4fhnB:
0.18
5dzkg-4fhnB:
11.01
5dzkm-4fhnB:
10.65
5dzkn-4fhnB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO B  96
LEU B 673
SER B  92
 None
 0.79A 5fsaB-4fhnB:
undetectable		 5fsaB-4fhnB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		5 / 11 VAL B 115
ILE B 131
ILE B 183
ILE B 195
PHE B 167
 None
 1.25A 5hw8G-4fhnB:
undetectable		 5hw8G-4fhnB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL B1013
GLN B1016
CYH B1018
 None
 0.83A 5icxA-4fhnB:
undetectable
5icxE-4fhnB:
undetectable		 5icxA-4fhnB:
12.79
5icxE-4fhnB:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU B 722
LEU B 725
TRP B 728
 None
 0.75A 5nwuA-4fhnB:
undetectable		 5nwuA-4fhnB:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 5 VAL B 766
LEU B 673
CYH B 674
ASP B  12
 None
 1.33A 5vcvA-4fhnB:
undetectable		 5vcvA-4fhnB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 GLN B 267
ILE B 195
HIS B 204
 None
 0.62A 5z12B-4fhnB:
undetectable		 5z12B-4fhnB:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		4 / 4 GLU B1042
VAL B1069
LEU B1073
THR B1081
 None
 1.01A 6dynA-4fhnB:
undetectable		 6dynA-4fhnB:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4fhn NUCLEOPORIN NUP120
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS B  66
SER B  76
SER B  64
 None
 1.04A 6gbfA-4fhnB:
undetectable		 6gbfA-4fhnB:
17.72