SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.08A 1dyiA-4fhoA:
undetectable		 1dyiA-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.11A 1dyiB-4fhoA:
undetectable		 1dyiB-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 9 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.00A 1eqgA-4fhoA:
undetectable		 1eqgA-4fhoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 11 VAL A 235
LEU A 226
ILE A 193
ALA A 215
LEU A 237
 None
 1.02A 1eqgB-4fhoA:
undetectable		 1eqgB-4fhoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.03A 1tdrA-4fhoA:
undetectable		 1tdrA-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 7 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.93A 1v55A-4fhoA:
undetectable
1v55J-4fhoA:
undetectable		 1v55A-4fhoA:
18.22
1v55J-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 SER A  37
LEU A 103
GLY A  93
VAL A  57
ALA A  56
 None
 1.30A 2kceA-4fhoA:
undetectable		 2kceA-4fhoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 ALA A  56
LEU A  81
LEU A 105
VAL A  88
ILE A  94
 None
 1.13A 3fl9B-4fhoA:
undetectable		 3fl9B-4fhoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 ALA A 205
LEU A 226
ILE A 220
LEU A 237
LEU A 213
 None
 1.14A 3k2hA-4fhoA:
undetectable		 3k2hA-4fhoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 6 VAL A 157
LEU A 182
ILE A 179
ASN A 196
 None
 0.90A 4a9kA-4fhoA:
undetectable		 4a9kA-4fhoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 5 VAL A 157
LEU A 182
ILE A 179
ASN A 196
 None
 0.97A 4a9kB-4fhoA:
undetectable		 4a9kB-4fhoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 ILE A  47
LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.38A 4fhbA-4fhoA:
undetectable		 4fhbA-4fhoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 ALA A 227
LEU A 229
VAL A 235
LEU A 213
ILE A 220
 None
 1.10A 4g1bA-4fhoA:
undetectable		 4g1bA-4fhoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		3 / 3 ARG A 214
HIS A 236
SER A 192
 SO4  A 600 (-2.7A)
None
None
 1.02A 4mjwA-4fhoA:
undetectable
4mjwB-4fhoA:
undetectable		 4mjwA-4fhoA:
19.58
4mjwB-4fhoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 5 ASN A 130
LEU A 132
SER A 151
ASN A 196
 None
 0.94A 4n09C-4fhoA:
undetectable		 4n09C-4fhoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 1.04A 4o2bD-4fhoA:
undetectable		 4o2bD-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 10 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.07A 4odoB-4fhoA:
undetectable		 4odoB-4fhoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 10 LEU A 149
LEU A 103
LEU A 116
LEU A 113
LEU A 160
 None
 1.08A 4odoC-4fhoA:
undetectable		 4odoC-4fhoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.14A 4qleA-4fhoA:
undetectable		 4qleA-4fhoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.12A 4qlgB-4fhoA:
undetectable		 4qlgB-4fhoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 ILE A 193
GLY A 194
ARG A 214
HIS A 236
ILE A 220
 None
None
SO4  A 600 (-2.7A)
None
None
 0.93A 4rvdA-4fhoA:
undetectable		 4rvdA-4fhoA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.14A 4x5fA-4fhoA:
undetectable		 4x5fA-4fhoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.09A 4x5gA-4fhoA:
undetectable		 4x5gA-4fhoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 ILE A  47
LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.26A 4x5hA-4fhoA:
undetectable		 4x5hA-4fhoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 7 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.96A 5b1aA-4fhoA:
undetectable
5b1aJ-4fhoA:
undetectable		 5b1aA-4fhoA:
18.22
5b1aJ-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 ILE A  47
LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.34A 5e8qB-4fhoA:
undetectable		 5e8qB-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 ILE A  47
LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.34A 5eajB-4fhoA:
undetectable		 5eajB-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
ILE A  78
LYS A  58
ALA A  60
 None
 0.93A 5eypB-4fhoA:
undetectable		 5eypB-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A 103
ALA A  83
LEU A  53
ILE A  78
LYS A  58
 None
 1.01A 5itzB-4fhoA:
undetectable		 5itzB-4fhoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		6 / 12 ILE A  47
LEU A  53
PHE A  48
THR A  61
ILE A  78
LEU A  97
 None
 1.34A 5ujxB-4fhoA:
undetectable		 5ujxB-4fhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 LEU A 103
LEU A  53
ILE A  78
LYS A  58
ALA A  60
 None
 0.95A 5xiwB-4fhoA:
undetectable		 5xiwB-4fhoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		5 / 12 ILE A 154
LEU A 173
ASN A 174
ILE A 138
LEU A 147
 None
 1.03A 6dwnC-4fhoA:
undetectable		 6dwnC-4fhoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 7 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.92A 6nmpA-4fhoA:
undetectable
6nmpJ-4fhoA:
undetectable		 6nmpA-4fhoA:
18.22
6nmpJ-4fhoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fho INTERNALIN C2
(Listeria
monocytogenes) 		4 / 5 ILE A  78
LEU A  81
THR A 120
LEU A 119
 None
 0.93A 6nmpN-4fhoA:
undetectable
6nmpW-4fhoA:
undetectable		 6nmpN-4fhoA:
18.22
6nmpW-4fhoA:
14.83